Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 7, 2003, Pages 4162-4167

  Farris, Wesley ^a,b   Mansourian, Stefan ^a,b   Chang, Yang ^a,b   Lindsley, Loren ^a,b   Eckman, Elizabeth A ^c   Frosch, Matthew P ^a,b   Eckman, Christopher B ^c   Tanzi, Rudolph E ^a,b   Selkoe, Dennis J ^a,b   Guénette, Suzanne ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; INSULIN; INSULINASE;

ALLELE; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 10; CONTROLLED STUDY; EMBRYO; ENZYME SUBSTRATE; GLUCOSE INTOLERANCE; HYPERINSULINEMIA; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEGRADATION; INSULIN METABOLISM; MICROGLIA; MUTATION; NERVE CELL CULTURE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; ANIMAL; BRAIN; CELL CULTURE; DISEASE MODEL; ENZYMOLOGY; GENETICS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; KINETICS; METABOLISM; MOUSE; MOUSE MUTANT; NERVE CELL; POLYMERASE CHAIN REACTION; RAT;

ANIMALIA; LEUCISCUS IDUS;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BLOOD GLUCOSE; BRAIN; CELLS, CULTURED; DISEASE MODELS, ANIMAL; GLUCOSE INTOLERANCE; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULYSIN; KINETICS; MICE; MICE, KNOCKOUT; NEURONS; POLYMERASE CHAIN REACTION; RATS;

EID: 0037390039     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0230450100     Document Type: Article

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