Hypocapnia induces caspase-3 activation and increases Aβ production

Neurodegenerative Diseases

Volumn 1, Issue 1, 2004, Pages 29-37

  Xie, Zhongcong ^a   Moir, Robert D ^a   Romano, Donna M ^a   Tesco, Giuseppina ^a   Kovacs, Dora M ^a   Tanzi, Rudolph E ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloid protein; Apoptosis; Caspase 3; Extracellular alkalosis; Hypocapnia; Hypoxia; Presenilin 1 mutation

Indexed keywords

AMYLOID BETA PROTEIN; CASPASE 3;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; COGNITIVE DEFECT; CONTROLLED STUDY; ENZYME ACTIVATION; GENETIC TRANSFECTION; GLIA CELL; HUMAN; HUMAN CELL; HYPOCAPNIA; HYPOXIA; NERVE CELL DIFFERENTIATION; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RISK FACTOR;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; APOPTOSIS; BLOTTING, WESTERN; CASPASE 3; CASPASES; CELL HYPOXIA; CELL LINE, TUMOR; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOCAPNIA; MEMBRANE PROTEINS; MUTATION; PRESENILIN-1; TRANSFECTION;

EID: 2342447294     PISSN: 16602854     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076667     Document Type: Article

References (40)

1. Tanzi RE, Bertram L: New frontiers in Alzheimer's disease genetics. Neuron 2001;32:181-184.
2. LeBlanc A: Increased production of 4 kDa amyloid beta peptide in serum deprived human primary neuron cultures: Possible involvement of apoptosis. J Neurosci 1995;15:7837-7846.
3. Gervais FG, Xu D, Robertson GS, et al: Involvement of caspases in proteolytic cleavage of Alzheimer's amyloid-beta precursor protein and amyloidogenic A beta peptide formation. Cell 1999;97:395-406.
4. LeBlanc A, Liu H, Goodyer C, Bergeron C, Hammond J: Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease. J Biol Chem 1999;274:23426-23436.
5. Holtzman DM, Deshmukh M: Caspases: A treatment target for neurodegenerative disease? Nat Med 1997;3:954-955.
6. Lunkes A, Trottier Y, Mandel JL: Pathological mechanisms in Huntington's disease and other polyglutamine expansion diseases. Essays Biochem 1998;33:149-163.
7. Namura S, Zhu J, Fink K, et al: Activation and cleavage of caspase-3 in apoptosis induced by experimental cerebral ischemia. J Neurosci 1998;18:3659-3668.
8. Kim TW, Pettingell WH, Jung YK, Kovacs DM, Tanzi RE: Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 1997;277:373-376.
9. Loetscher H, Deuschle U, Brockhaus M, et al: Presenilins are processed by caspase-type proteases. J Biol Chem 1997;272:20655-20659.
10. Barnes NY, Li L, Yoshikawa K, Schwartz LM, Oppenheim RW, Milligan CE: Increased production of amyloid precursor protein provides a substrate for caspase-3 in dying motoneurons. J Neurosci 1998;18:5869-5880.
11. Dodds C, Allison J: Postoperative cognitive deficit in the elderly surgical patient. Br J Anaesth 1998;81:449-462.
12. 2 changes, and visual evoked potentials in mechanically ventilated, preterm infants. Acta Paediatr Scand 1987;76:394-400.
13. Wollman SB, Orkin LR: Postoperative human reaction time and hypocarbia during anaesthesia. Br J Anaesth 1968;40:920-926.
14. Laffey JG, Kavanagh BP: Hypocapnia. N Engl J Med 2002;347:43-53.
15. Vannucci RC, Brucklacher RM, Vannucci SJ: Effect of carbon dioxide on cerebral metabolism during hypoxia-ischemia in the immature rat. Pediatr Res 1997;42:24-29.
16. Ohyu J, Endo A, Itoh M, Takashima S: Hypocapnia under hypotension induces apoptotic neuronal cell death in the hippocampus of newborn rabbits. Pediatr Res 2000;48:24-29.
17. Kovacs DM, Mancini R, Henderson J, et al: Staurosporine-induced activation of caspase-3 is potentiated by presenilin 1 familial Alzheimer's disease mutations in human neuroglioma cells. J Neurochem 1999;73:2278-2285.
18. Mattson MP, Zhu H, Yu J, Kindy MS: Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: Involvement of perturbed calcium homeostasis. J Neurosci 2000;20:1358-1364.
19. Perez-Tur J, Froelich S, Prihar G, et al: A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport 1995;7:297-301.
20. Mullan M, Crawford F, Axelman K, et al: A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid. Nat Genet 1992;1:345-347.
21. Selkoe DJ: Alzheimer's disease: Genes, proteins, and therapy. Physiol Rev 2001;81:741-766.
22. Jenner P, Olanow CW: Understanding cell death in Parkinson's disease. Ann Neurol 1998;44:S72-84.
23. Polymeropoulos MH: Autosomal dominant Parkinson's disease. J Neurol 1998;245:P1-3.
24. Sawa A, Wiegand GW, Cooper J, et al: Increased apoptosis of Huntington disease lymphoblasts associated with repeat length-dependent mitochondrial depolarization. Nat Med 1999;5:1194-1198.
25. Ona VO, Li M, Vonsattel JP, et al: Inhibition of caspase-1 slows disease progression in a mouse model of Huntington's disease. Nature 1999;399:263-267.
26. Kostic V, Jackson-Lewis V, de Bilbao F, Dubois-Dauphin M, Przedborski S: Bcl-2: Prolonging life in a transgenic mouse model of familial amyotrophic lateral sclerosis. Science 1997;277:559-562.
27. Hara H, Fink K, Endres M, et al: Attenuation of transient focal cerebral ischemic injury in transgenic mice expressing a mutant ICE inhibitory protein. J Cereb Blood Flow Metab 1997;17:370-375.
28. Murakami K, Kondo T, Kawase M, et al: Mitochondrial susceptibility to oxidative stress exacerbates cerebral infarction that follows permanent focal cerebral ischemia in mutant mice with manganese superoxide dismutase deficiency. J Neurosci 1998;18:205-213.
29. Keller JN, Kindy MS, Holtsberg FW, et al: Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction. J Neurosci 1998;18:687-697.
30. Guo Q, Sebastian L, Sopher BL, et al: Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: Central roles of superoxide production and caspase activation. J Neurochem 1999;72:1019-1029.
31. Tesco G, Kim TW, Diehlmann A, Beyreuther K, Tanzi RE: Abrogation of the presenilin 1/beta-catenin interaction and preservation of the heterodimeric presenilin 1 complex following caspase activation. J Biol Chem 1998;273:33909-33914.
32. Guo Q, Furukawa K, Sopher BL, et al: Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide. Neuroreport 1996;8:379-383.
33. Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP: Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. Neurobiol Dis 2002;11:2-19.
34. Wolozin B, Alexander P, Palacino J: Regulation of apoptosis by presenilin 1. Neurobiol Aging 1998;19:S23-27.
35. Giffard R, Weiss J, Choi D: Extracellular alkalinity exacerbates injury of cultured neurons. Stroke 1992;23:1817-1821.
36. Giffard R, Monyer H, Christine C, Choi D: Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res 1990;506:339-342.
37. Ou-Yang Y, Kristian T, Mellergard P, Siesjo B: The influence of pH on glutamate- and depolarization-induced increases of intracellular calcium concentration in cortical neurons in primary culture. Brain Res 1994;646:65-72.
38. Majima HJ, Oberley TD, Furukawa K, et al: Prevention of mitochondrial injury by manganese superoxide dismutase reveals a primary mechanism for alkaline-induced cell death. J Biol Chem 1998;273:8217-8224.
39. Li P, Nijhawan D, Budihardjo I, et al: Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997;91:479-489.
40. Zou H, Li Y, Liu X, Wang X: An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J Biol Chem 1999;274:11549-11556.