Substrate activation of insulin-degrading enzyme (Insulysin): A potential target for drug development

Journal of Biological Chemistry

Volumn 278, Issue 50, 2003, Pages 49789-49794

  Song, Eun Suk ^a   Juliano, Maria Aparecida ^c   Juliano, Luiz ^c   Hersh, Louis B ^a,b  

^a UNIVERSITY OF KENTUCKY   (United States)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c NONE

Author keywords

[No Author keywords available]

Indexed keywords

CATALYSIS; DIMERS; DRUG PRODUCTS; HYDROLYSIS; INSULIN; SUBSTRATES;

GEL FILTRATION ANALYSIS;

ENZYMES;

AMYLOID BETA PROTEIN; BRADYKININ; DYNORPHIN B; INSULIN; INSULINASE; PEPTIDE;

ANIMAL CELL; ARTICLE; BINDING SITE; CATALYSIS; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME DEGRADATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENETIC LINKAGE; HYDROLYSIS; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BINDING SITES; CHROMATOGRAPHY, GEL; COS CELLS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; DYNORPHINS; ENDORPHINS; ENZYME ACTIVATION; HYDROLYSIS; INSECTS; INSULIN; INSULYSIN; KINETICS; METALLOENDOPEPTIDASES; PEPTIDES; PRECIPITIN TESTS; PROTEIN CONFORMATION; RATS; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TIME FACTORS; TRYPSIN;

ANIMALIA; LEUCISCUS IDUS;

EID: 0348010388     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M308983200     Document Type: Article

References (27)

1. Duckworth, W. C., Bennett, R. G., and Hamel, F. G. (1998) Endocr. Rev. 19, 608-624
2. Seta, K. A., and Roth, R. A. (1997) Biochem. Biophys. Res. Commun. 231, 167-171
3. Vekrellis, K., Ye, Z., Qiu, W. Q., Walsh, D., Hartley, D., Chesneau, V., Rosner, M. R., and Selkoe, D. J. (2000) J. Neurosci. 20, 1657-1665
4. Qiu, W. Q., Walsh, D. M., Ye, Z., Vekrellis, K., Zhang, J., Podlisny, M. B., Rosner, M. R., Safavi, A., Hersh, L. B., and Selkoe, D. J. (1998) J. Biol. Chem. 273, 32730-32738
5. Authier, F., Posner, B. I., and Bergeron, J. J. M. (1996) Clin. Investig. Med. 19, 149-160
6. Safavi, A., Miller, B. C., Cottam, L., and Hersh, L. B. (1996) Biochemistry 35, 14318-14325
7. Kirschner, R. J., and Goldberg, A. L. (1983) J. Biol. Chem. 258, 967-976
8. Muller, D., Baumeister, H., Buck, F., and Richter, D. (1991) Eur. J. Biochem. 202, 285-292
9. Garcia, J. V., Gehm B. D., and Rosner, M. R. (1989) J. Cell Biol. 109, 1301-1307
10. Gehm B. D., and Rosner, M. R. (1991) Endocrinology 128, 1603-1610
11. Muller, D., Schulze, C., Baumeister, H., Buck, F., and Richter, D. (1992) Biochemistry 31, 11138-11143
12. Bennett, R. G., Duckworth, W. C., and Hamel, F. G. (2000) J. Biol. Chem. 275, 36621-36625
13. Kurochkin, I. V., and Goto, S. (1994) FEBS Lett. 345, 33-37
14. McDermott, J. R., and Gibson, A. M. (1997) Neurochem. Res. 22, 49-56
15. Mukherjee, A., Song, E-S, Kihiko, M., Goodman, J. P., Jr., Pyrek, J. S., Estus, S. and Hersh, L. B. (2000) J. Neurosci. 20, 8745-8749
16. Bertram, L., Saunders, A. J., Mullin, K., Sampson, A., Moscarillo, T. J., Basset, S. S., Go, R. C., Blacker, D., and Tanzi, R. E. (2000) Science 290, 2302-2303
17. Ertekin-Taner, N., Graff-Radford, N., Younkin, L. H., Eckman, C., Baker, M., Adamson, J., Ronald, J., Blangero, J., Hutton, M., and Younkin, S. G. (2000) Science 290, 2303-2304
18. Myers, A., Holmans, P., Marshall, H., Kwon, J., Meyer, D., Ramic, D., Shears, S., Booth, J., DeVrieze, F. W., Crook, R., Hamshere, M., Abraham, R., Tunstall, N., Rice, F., Carty, S., Lillystone, S., Kehoe, P., Rudrasingham, V., Jones, L., Lovestone, S., Perez-Tur, J., Williams, J., Owen, M. J., Hardy, J., and Goate, A. M. (2000) Science 290, 2304-2305
19. Abraham, R., Myers, A., Wavrant-DeVrieze, F., Hamshere, M. L., Thomas, H. V., Marshall, H., Compton, D., Spurlock, G., Turic, D., Hoogendoorn, B., Kwon, J. M., Petersen, R. C., Tangalos, E., Norton, J., Morris, J. C., Bullock, R., Liolitsa, D., Lovestone, S., Hardy, J., Goate, A., O'Donovan, M., Williams, J., Owen, M. J., and Jones, L. (2001) Hum. Genet. 109, 646-652
20. Miller, B. C., Eckman, E. A., Sambamurti, K., Dobbs, N., Chow, K. M., Eckman, C. B., Hersh, L. B., and Thiele, D. L. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 6221-6226
21. Farris, W., Mansourian, S., Chang, Y., Lindsley, L., Eckman, E. A., Frosch, M. P., Eckman, C. B., Tanzi, R. E., Selkoe, D. J., and Guenette, S. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 4162-4167
22. Csuhai, E., Juliano, M. A., Pyrek, J. S., Harms, A. C., Juliano, L., and Hersh, L. B (1999) Anal. Biochem. 269, 149-154
23. Song, E-S., Mukherjee, A. Juliano, M. A., St. Pyrek, J., Goodman, J. P., Jr., Juliano, L., and Hersh, L. B. (2001) J. Biol. Chem. 276, 1152-1155
24. Ma, Z., Chow, K. M., Csuhai, E., and Hersh, L. B. (2002) Arch. Biochem. Biophys. 401, 198-204
25. Klafki, H. W., Wiltfang, J., and Staufenbiel, M. (1996) Anal. Biochem. 237, 24-29
26. Garcia, J. V., Fenton, B. W., and Rosner, M. R. (1988) Biochemistry 27, 4237-4244
27. Camberos, M. C., Perez, A. A., Udrisar, D. P., Wanderley, M. I., and Cresto, J. C. (2001) Exp. Biol. Med. 226, 334-341