Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

Brain Research

Volumn 840, Issue 1-2, 1999, Pages 23-35

  Larson, John ^a,d   Lynch, Gary ^b   Games, Dora ^c   Seubert, Peter ^c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c ELAN PHARMACEUTICALS   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

Author keywords

Amyloid; Alzheimer's disease; Amyloid precursor protein; CA1; Long term potentiation; Paired pulse facilitation; Transgenic

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN;

AGING; ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; IMMUNOHISTOCHEMISTRY; LONG TERM POTENTIATION; MOUSE; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; SYNAPTIC TRANSMISSION; TRANSGENIC MOUSE;

AGING; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ELECTRIC STIMULATION; EXCITATORY POSTSYNAPTIC POTENTIALS; HIPPOCAMPUS; HUMANS; LONG-TERM POTENTIATION; MICE; MICE, TRANSGENIC; MUTATION; SENILE PLAQUES; SYNAPTIC TRANSMISSION;

EID: 0033523480     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01698-4     Document Type: Article

References (34)

1. Selkoe D. Alzheimer disease: a central role for amyloid. J. Neuropath. Exp. Neurol. 53:1994;438-447.
2. Squire L.R., Zola S.M. Structure and function of declarative and nondeclarative memory systems. Proc. Natl. Acad. Sci. U.S.A. 93:1996;13515-13522.
3. Chartier-Harlin M.-C., Crawford F., Houlden H., Warren A., Hughes D., Fidani L., Goate A., Rossor M., Roques P., Hardy J., Mullan M. Early-onset Alzheimer's disease caused by mutations at codon 717 of the β-amyloid precursor protein gene. Nature. 353:1991;844-846.
4. Goate A., Chartier-Harlin M.-C., Mullan M., Brown J., Crawford F., Fidani L., Guiffra L., Haynes A., Irving N., James L., Mant R., Newton P., Rooke K., Roques P., Talbot C., Pericak-Vance M., Roses A., Williamson R., Rossor M., Owen M., Hardy J. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature. 349:1991;704-706.
5. Murrell J., Farlow M., Ghetti B., Benson M.D. A mutation in the amyloid precursor protein associated with hereditary Alzheimer's disease. Science. 254:1991;97-99.
6. Citron M., Oltersdorf T., Haass C., McConlogue L., Hung A.Y., Seubert P., Vigo-Pelfrey C., Lieberburg I., Selkoe D.J. Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production. Nature. 360:1992;672-674.
7. Haass C., Lemere C.A., Capell A., Citron M., Seubert P., Schenk D., Lannfelt L., Selkoe D.J. The Swedish mutation causes early-onset Alzheimer's disease by β-secretase cleavage within the secretory pathway. Nature Med. 1:1995;1291-1296.
8. 717) mutants. Science. 264:1994;1336-1340.
9. Levy-Lahad E., Wasco W., Poorkaj P., Romano D.M., Oshima J., Pettingell W.H., Yu C., Jondro P.D., Schmidt S.D., Wang K., Crowley A.C., Fu Y.-H., Guenette S.Y., Galas D., Nemens E., Wijsman E.M., Bird T.D., Schellenberg G.D., Tanzi R.E. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science. 269:1995;973-977.
10. Sherrington R., Froelich S., Sorbi S., Campion D., Chi H., Rogaeva E.A., Levesque G., Rogaev E.I., Lin C., Liang Y., Ikeda M., Mar L., Brice A., Agid Y., Percy M.E., Clerget-Darpoux F., Piacentini S., Marcon G., Nacmias B., Amaducci L., Frebourg T., Lannfelt L., Rommens J.M., St. George-Hyslop P.H. Alzheimer's disease associated with mutations in presenilin 2 is rare and variably penetrant. Hum. Mol. Genet. 5:1996;985-988.
11. Citron M., Westaway D., Xia W., Carlson G., Diehl T., Levesque G., Johnson-Wood K., Lee M., Seubert P., Davis A., Kholodenko D., Motter R., Sherrington R., Perry B., Yao H., Strome R., Lieberburg I., Rommens J., Kim S., Schenk D., Fraser P., St. George Hyslop P.G., Selkoe D.J. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3:1997;67-72.
12. Scheuner D., Eckman C., Jensen M., Song X., Citron M., Suzuki N., Bird T.D., Hardy J., Hutton M., Kukull W., Larson E., Levy-Lahad E., Viitanen M., Peskind E., Poorkaj P., Schellenberg G., Tanzi R., Wasco W., Lannfelt L., Selkoe D., Younkin S. Secreted amyloid β-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2:1996;864-870.
13. D'Hooge R., Nagels G., Westland C.E., Mucke L., De Deyn P.P. Spatial learning deficit in mice expressing human 751-amino acid β-amyloid precursor protein. NeuroReport. 7:1996;2807-2811.
14. Games D., Adams D., Alessandrini R., Barbour R., Berthelette P., Blackwell C., Carr T., Clemens J., Donaldson T., Gillespie F., Guido T., Hagoplan S., Johnson-Wood K., Khan K., Lee M., Liebowitz P., Lieberburg I., Little S., Masliah E., McConlogue L., Montoya-Zavala M., Mucke L., Paganini L., Penniman E., Power M., Schenk D., Seubert P., Snyder B., Soriano F., Tan H., Vitale J., Wadsworth S., Wolozin B., Zhao J. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature. 373:1995;523-527.
15. Hsiao K., Chapman P., Nilsen S., Eckman C., Harigaya Y., Younkin S., Yang F., Cole G. Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice. Science. 274:1996;99-102.
16. Reaume A.G., Howland D.S., Trusko S.P., Savage M.J., Lang D.M., Greenberg B.D., Siman R., Scott R.W. Enhanced amyloidogenic processing of the β-amyloid precursor protein in gene-targeted mice bearing the Swedish familial Alzheimer's disease mutations and a "humanized" Aβ sequence. J. Biol. Chem. 271:1996;23380-23388.
17. Sturchler-Pierrat C., Abramowski D., Duke M., Wiederhold K.H., Mistl C., Rothacher S., Ledermann B., Burki K., Frey P., Paganetti P.A., Waridel C., Calhoun M.E., Jucker M., Probst A., Staufenbiel M., Sommer B. Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology. Proc. Natl. Acad. Sci. U.S.A. 94:1997;13287-13292.
18. Wyss-Coray T., Masliah E., Mallory M., McConlogue L., Johnson-Wood K., Lin C., Mucke L. Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease. Nature. 389:1997;603-606.
19. 42 deposition in a transgenic mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 94:1997;1550-1555.
20. Masliah E., Sisk A., Mallory M., Mucke L., Schenk D., Games D. Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F β-amyloid precursor protein and Alzheimer's disease. J. Neurosci. 16:1996;5795-5811.
21. Larson J., Lynch G. Role of N-methyl-D-aspartate receptors in the induction of synaptic potentiation by burst stimulation patterned after the hippocampal theta rhythm. Brain Res. 441:1988;111-118.
22. Larson J., Lynch G. Induction of synaptic potentiation in hippocampus by patterned stimulation involves two events. Science. 232:1986;985-988.
23. Pacelli G.J., Su W., Kelso S.R. Activity-induced decrease in early and late inhibitory synaptic conductances in hippocampus. Synapse. 7:1991;1-13.
24. Larson J., Wong D., Lynch G. Patterned stimulation at the theta frequency is optimal for induction of hippocampal long-term potentiation. Brain Res. 368:1986;347-350.
25. Chapman P.F., White G.L., Jones M.W., Cooper-Blacketer D., Marshall V.J., Irizarry M., Younkin L., Good M.A., Bliss T.V.P., Hyman B.T., Younkin S.G., Hsiao K.K. Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice. Nature Neurosci. 2:1999;271-276.
26. Hsia A.Y., Masliah E., McConlogue L., Yu G.-Q., Tatsuno G., Hu K., Kholodenko D., Malenka R.C., Nicoll R.A., Mucke L. Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc. Natl. Acad. Sci. U.S.A. 96:1999;3228-3233.
27. Nalbantoglu J., Tirado-Santiago G., Lahsaini A., Poirier J., Goncalves O., Verge G., Momoli F., Welner S.A., Massicotte G., Julien J.P., Shapiro M.L. Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein. Nature. 387:1997;500-505.
28. Creager R., Dunwiddie T., Lynch G. Paired-pulse and frequency facilitation in the CA1 region of the in vitro rat hippocampus. J. Physiol. (London). 299:1980;409-424.
29. Muller D., Lynch G. Evidence that changes in presynaptic calcium currents are not responsible for long-term potentiation in hippocampus. Brain Res. 479:1989;290-299.
30. Guo Q., Robinson N., Mattson M.P. Secreted β-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-6B and stabilization of calcium homeostasis. J. Biol. Chem. 273:1998;12341-12351.
31. 2+ increase in rat cultured hippocampal neurones. Br. J. Pharmacol. 123:1998;1483-1489.
32. Koo E.H., Sisodia S.S., Archer D.R., Martin L.J., Weidemann A., Beyreuther K., Fischer P., Masters C.L., Price D.L. Precursor of amyloid protein in Alzheimer disease undergoes fast anterograde axonal transport. Proc. Natl. Acad. Sci. U.S.A. 87:1990;1561-1565.
33. Morin P.J., Abraham C.R., Amaratunga A., Johnson R.J., Huber G., Sandell J.H., Fine R.E. Amyloid precursor protein is synthesized by retinal ganglion cells, rapidly transported to the optic nerve plasma membrane and nerve terminals, and metabolized. J. Neurochem. 61:1993;464-473.
34. Schubert D., Prior R., Weidemann A., Dircksen H., Multhaup G., Masters C.L., Beyreuther K. Localization of Alzheimer βA4 amyloid precursor protein at central and peripheral synaptic sites. Brain Res. 563:1991;184-194.