Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

Neurobiology of Disease

Volumn 11, Issue 1, 2002, Pages 2-19

  Chan, Sic L ^a   Culmsee, Carsten ^b   Haughey, Norman ^a   Klapper, Wolfram ^a   Mattson, Mark P ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b PHILIPPS UNIVERSITY MARBURG   (Germany)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Endoplasmic reticulum; Hippocampal neurons; PARP; Topoisomerase

Indexed keywords

CALCIUM; CALPAIN; CASPASE; CASPASE 12; CASPASE INHIBITOR; CHELATING AGENT; CYCLOHEXIMIDE; PRESENILIN 1; PROTEIN P53; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL DEATH; CELL STRAIN; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DAMAGE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME INHIBITION; HIPPOCAMPUS; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RAT; REGULATORY MECHANISM;

EID: 0036452908     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1006/nbdi.2002.0542     Document Type: Article

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