Intracellularly generated amyloid-β peptide counteracts the antiapoptotic function of its precursor protein and primes proapoptotic pathways for activation by other insults in neuroblastoma cells

Journal of Neurochemistry

Volumn 91, Issue 6, 2004, Pages 1260-1274

  Esposito, Luke ^a   Gan, Li ^a   Yu, Gui Qiu ^a   Essrich, Christian ^a   Mucke, Lennart ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b GLADSTONE INSTITUTE OF NEUROLOGICAL DISEASE   (United States)

Author keywords

Alzheimer's disease; Amyloid; Apoptosis; Endoplasmic reticulum; Neurodegeneration; p53

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; GLUCOSE; MESSENGER RNA; MUTANT PROTEIN; PROTEIN; PROTEIN P53; PROTEIN P78; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL CELL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENETIC TRANSFECTION; HUMAN; MOUSE; NERVE DEGENERATION; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; STRESS; TRANSACTIVATION; WILD TYPE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; APOPTOSIS; ASPARTIC ENDOPEPTIDASES; CELL LINE, TUMOR; CELL SURVIVAL; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; EXTRACELLULAR FLUID; HUMANS; INTRACELLULAR MEMBRANES; MUTATION; NEUROBLASTOMA; TRANS-ACTIVATION (GENETICS); TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 10644290831     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2004.02816.x     Document Type: Article

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