Lack of correlation between plaque burden and cognition in the aged monkey

Acta Neuropathologica

Volumn 94, Issue 5, 1997, Pages 471-478

  Sloane, J A ^a   Pietropaolo, M F ^a   Rosene, D L ^a,b   Moss, M B ^a,b   Peters, A ^a,b   Kemper, T ^a   Abraham, C R ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

Author keywords

6E10; Aging; Amyloid; Macaca mulatta; Rhesus

Indexed keywords

AMYLOID BETA PROTEIN;

AGED; AGING; ANIMAL TISSUE; ARTICLE; COGNITIVE DEFECT; IMMUNOHISTOCHEMISTRY; MACACA; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY;

AGING; AMYLOID BETA-PROTEIN; ANIMALS; BRAIN; BRAIN CHEMISTRY; FEMALE; IMMUNOHISTOCHEMISTRY; MACACA MULATTA; MALE; NEUROBEHAVIORAL MANIFESTATIONS; SENILE PLAQUES;

EID: 0030815429     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010050735     Document Type: Article

References (58)

1. Abraham CR, Selkoe DJ, Potter H, Price DL, Cork LC (1989) α1-Antichymotrypsin is present together with the β-protein in monkey brain amyloid deposits. Neuroscience 32:715-720
2. Amaral DG (1993) Morphological analysis of the brains of behaviorally characterized aged nonhuman primates. Neurobiol Aging 14:671-672
3. Arnsten AFT, Goldman-Rakic PS (1990) Analysis of α-2 adrenergic agonist effects on the delayed nonmatch-to-sample performance of aged rhesus monkeys. Neurobiol Aging 11:583-590
4. Bachevalier J, Landis LC, Walker M, Brickson M, Mishkin M, Price DL, Cork LC (1991) Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction. Neurobiol Aging 12:99-111
5. Baker HF, Ridley RM, Duchen LW, Crow TJ, Bruton CJ (1994) Induction of beta (A4)-amyloid in primates by injection of Alzheimer's disease brain homogenate. Comparison with transmission of spongiform encephalopathy, Mol Neurobiol 8:25-39
6. Bartus JM, Fleming D, Johnson HR (1978) Aging in the rhesus monkey: debilitating effects on short term memory. J Gerontol 34:209-219
7. Bates JF, Goldman-Rakic PS (1993) Prefrontal connections of medial motor areas in the rhesus monkey. J Comp Neurol 336:211-228
8. Beal MF (1995) Aging, energy, and oxidative stress in neurodegenerative diseases. Ann Neurol 38:357-366
9. Cork LC (1993) Plaques in prefrontal cortex of aged, behaviorally tested rhesus monkeys: incidence, distribution, and relationship to task performance. Neurobiol Aging 14:675-676
10. Cork LC, Masters C, Beyreuther K, Price DL (1990) Development of senile plaques: relationships of neuronal abnormalities and amyloid deposits. Am J Pathol 137:1383-1392
11. Cortopassi G, Liu Y (1995) Genotypic selection of mitochondrial and oncogenic mutations in human tissue suggests mechanisms of age-related pathophysiology. Mutat Res 338:151-159
12. Floyd RA, Carney JM (1992) Free radical damage to protein and DNA: mechanisms involved and relevant observations on brain undergoing oxidative stress. Ann Neurol 32:S22-S27
13. Galaburda AM, Pandya DK (1983) The intrinsic architectonic and connectional organization of the superior temporal region of the rhesus monkey. J Comp Neurol 221:169-184
14. Gearing M, Rebeck GW, Hyman BT, Tigges J, Mirra SS (1994) Neuropathology and apolipoprotein E profile of aged chimanzees: implications for Alzheimer disease. Proc Natl Acad Sci USA 91:9382-9386
15. Gearing M, Tigges J, Mori H, Mirra SS (1996) Aβ40 is a major form of β-amyloid in nonhuman primates. Neurobiol Aging 17:903-908
16. Heilbroner PL, Kemper TL (1990) The cytoarchitectonic distribution of senile plaques in three aged monkeys. Acta Neuropathol 81:60-65
17. Inouye SK, Albert MS, Mohs R, Sun K, Berkman LF (1993) Cognitive performance in a high-functioning community-dwelling elderly population. J Gerontol 48:146-151
18. Kalaria RN (1994) Brain microvasculature in aging. Neurobiol Aging 15:765-766
19. Kanemaru K, Iwatsubo T, Ihara Y (1996) Comparable amyloid β-protein (Aβ) 42(43) and Aβ40 deposition in the aged monkey brain. Neurosci Lett 214:196-198
20. Kim KS, Wen GY, Bancher C, Chen CMJ, Sapienza VJ, Hong H, Wisniewski HM (1990) Detection and quantitation of amyloid β-peptide with 2 monoclonal antibodies. Neurosci Res Commun 7:113-122
21. Kitt CA, Price DL, Struble RG, Cork LC, Wainer BH, Becher MW, Mobley WC (1984) Evidence for cholinergic neuntes in senile plaques. Science 226:1443-1445
22. Kitt CA, Struble RG, Cork LC, Mobley WC, Walker LC, Joh TH, Price DL (1985) Catecholaminergic neuntes in senile plaques in prefrontal cortex of aged nonhuman primates. Neuroscience 16:691-699
23. Lai ZC, Rosene DL, Killiany RJ, Pugliese D, Albert MS, Moss MB (1995) Age-related changes in the brain of the rhesus monkey: MRI changes in white matter but not grey matter. Soc Neurosci Abstr 21:1564
24. Marriott JG, Abelson JS (1980) Age differences in short-term memory of test-sophisticated rhesus monkeys. Age 3:7-9
25. Martin LJ, Sisodia SS, Koo EH, Cork LC, Dellovade TL, Weidemann A, Beyreuther K, Masters C, Price DL (1991) Amyloid precursor protein in aged nonhuman primates. Proc Natl Acad Sci USA 88:1461-1465
26. Mattson MP (1994) Calcium and neuronal injury in Alzheimer's disease, contributions of beta-amyloid precursor protein mismetabolism, free radicals, and metabolic compromise. Ann NY Acad Sci 747:50-76
27. Medin DL, Davis RT (1974) In: Schrier AM, Stollmitz F (eds) Behavior of non-human primates. Academic Press, New York, pp 1-47
28. Mooradian AD (1994) Potential mechanisms of the age-related changes in the blood-brain barrier. Neurobiol Aging 15:751-755
29. Moss MB, Rosene DL, Peters A (1988) Effects of aging on visual recognition memory in the rhesus monkey. Neurobiol Aging 9:495-502
30. Moss MB, Killiany RJ, Lai ZC, Rosene DL, Herndon J (1997) Recognition memory span in monkeys of advanced age. Neurobiol Aging 18:13-19
31. Pandya DK, Seltzer B (1982) Intrinsic connections and architectonics of posterior pareital cortex in the rhesus monkey. J Comp Neurol 204:196-210
32. Peters A, Gruia-Leahu D, Moss MB, McNally K (1994) The effects of aging on area 46 of the frontal cortex of the rhesus monkey. Cereb Cortex 6:621-635
33. Poduri A, Gearing M, Rebeck GW, Mirra SS, Tigges J, Hyman BT (1994) Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys. Am J Pathol 144:1183-1187
34. Presty SK, Bachevalier J, Walker LC, Struble RG, Price DL, Mishkin M, Cork LC (1987) Age differences in recognition memory of the rhesus monkey (Macaco mulatto). Neurobiol Aging 8:435-440
35. Price JL, Davis PB, Morris JC, White DL (1991) The distribution of tangles, plaques and related immunohistochemical markers in healthy aging and Alzheimer's disease. Neurobiol Aging 12:295-312
36. Rapp PR, Amaral DG (1989) Evidence for a task-dependent memory dysfunction in the aged monkey. J Neurosci 9:3568-3576
37. Rapp PR, Amaral DG (1991) Recognition memory deficits in a subpopulation of aged monkeys resemble the effects of medial temporal lobe damage. Neurobiol Aging 12:481-486
38. Reiter RJ (1995) Oxidative processes and antioxidative defense mechanisms in the aging brain. FASEB J 9:526-533
39. Rosene DL (1993) Comparing age-related changes in the basal forebrain and hippocampus of the rhesus monkey. Neurobiol Aging 14:669-670
40. Rosene DL, Rhodes KJ (1990) Cryprotection and freezing methods for controlling ice crystal artifact in frozen sections of fixed and unfixed brain tissue. Methods Neurosci 3:360-385
41. Rylett RJ, Williams LR (1994) Role of neurotrophins in cholinergic-neurone function in the adult and aged CNS. Trends Neurosci 17:486-490
42. Sandyk R, Willis GL (1992) Amine accumulation: a possible precursor of Lewy body formation in Parkinson's disease. Int J Neurosci 66:61-74
43. Savaki HE, Kennedy C, Sokoloff L, Mishkin M (1993) Visually guided reaching with the forelimb contralateral to a "blind" hemisphere: a metabolic mapping study in monkeys. J Neurosci 13:2772-2789
44. Selkoe DJ (1994) Amyloid beta-protein precursor: new clues to the genesis of Alzheimer's disease. Curr Opin Neurobiol 4:708-716
45. Selkoe DJ, Abraham CR, Podlisny MB, Duffy LK (1986) Isolation of low-molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J Neurochem 46:1820-1834
46. Selkoe DJ, Bell DS, Podlisny MB, Price DL, Cork LC (1987) Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease. Science 235:873-877
47. Seltzer B, Pandya DK (1978) Afferent cortical connections and architectonics of the superior temporal sulcus and surrounding cortex in the rhesus monkey. Brain Res 149:1-24
48. Struble RG, Cork LC, Whitehouse PJ, Price DL (1982) Cholinergic innervation in neuritic plaques. Science 216:413-415
49. Struble RG, Kitt CA, Walker LC, Cork LC, Price DL (1984) Somatostatinergic neurites in senile plaques of aged non-human primates. Brain Res 324:394-396
50. Struble RG, Price DL Jr, Cork LC, Price DL (1985) Senile plaques in cortex of aged normal monkeys. Brain Res 361:267-275
51. Talamo BR, Feng WH, Perez-Cruet M, Adelman L, Kosik K, Lee My, Cork LC, Kauer JS (1991) Pathologic changes in olfactory neurons in Alzheimer's disease. Ann NY Acad Sci 640:1-7
52. Uno H, Walker LC (1993) The age of biosenescence and the incidence of cerebral beta-amyloidosis in aged captive rhesus monkeys. Ann NY Acad Sci 695:232-235
53. Walker AE (1940) A cytoarchitectural study of the pre-frontal area of the macaque monkey. J Comp Neurol 73:59-86
54. Walker LC, Kitt CA, Struble RG, Schmechel DE, Oertel WH, Cork LC, Price DL (1985) Glutamic acid decarboxylase-like immunoreactive neurites in senile plaques. Neurosci Lett 59:165-169
55. Walker LC, Kitt CA, Schwam E, Buckwald B, Garcia F, Sepinwall J, Price DL (1987) Senile plaques in aged squirrel monkeys. Neurobiol Aging 8:291-296
56. Walker LC, Kitt CA, Cork LC, Struble RG, Dellovade TL, Price DL (1988) Multiple transmitter systems contribute neurites to individual plaques. J Neuropathol Exp Neurol 47:138-144
57. Walker LC, Masters C, Beyreuther K, Price DL (1990) Amyloid in the brains of aged squirrel monkeys. Acta Neuropathol 80:381-387
58. Wisniewski HM, Ghetti B, Terry RD (1973) Neuritic (senile) plaques and filamentous changes in aged rhesus monkeys. J Neuropathol Exp Neurol 32:566-584