Metabolism of the "Swedish" amyloid precursor protein variant in neuro2a (N2a) cells: Evidence that cleavage at the "β-secretase" site occurs in the Golgi apparatus

Journal of Biological Chemistry

Volumn 271, Issue 16, 1996, Pages 9390-9397

  Thinakaran, Gopal ^a   Teplow, David B ^b   Siman, Robert ^c   Greenberg, Barry ^c   Sisodiat, Sangram S ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c CEPHALON INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SUBSTRATE; GENE EXPRESSION; GOLGI COMPLEX; MOUSE; NEUROBLASTOMA CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN VARIANT;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; CELL LINE; CELL MEMBRANE; ENDOPEPTIDASES; GOLGI APPARATUS; HUMANS; KINETICS; MICE; MODELS, NEUROLOGICAL; MOLECULAR SEQUENCE DATA; MUTATION; NEUROBLASTOMA; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VARIATION (GENETICS);

EID: 0029942495     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.16.9390     Document Type: Article

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