Calpain inhibitor I increases β-amyloid peptide production by inhibiting the degradation of the substrate of γ-secretase: Evidence that substrate availability limits β-amyloid peptide production

Journal of Biological Chemistry

Volumn 274, Issue 13, 1999, Pages 8966-8972

  Zhang, Lili ^a   Song, Lixin ^a   Parker, Eric M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CALPASTATIN; GAMMA SECRETASE; N ACETYLLEUCYLLEUCYLNORLEUCINAL; PROTEINASE; UNCLASSIFIED DRUG;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CONCENTRATION RESPONSE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN SECRETION; PROTEIN SYNTHESIS;

EID: 0033605588     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.13.8966     Document Type: Article

References (23)

1. Selkoe, D. (1994) Annu. Rev. Cell Biol. 10, 373-403
2. Selkoe, D. J. (1996) J. Biol. Chem. 271, 18295-18258
3. Hardy, J. (1997) Trends Neurosci. 20, 154-159
4. Borchelt, D., Thinakaran, G., Eckman, C., Lee, M., Davenport, F., Ratovitsky, T., Prada, C., Kim, G., Seekins, S., Yager, D., Slunt, H., Wang, R., Seeger, M., Levey, A., Gandy, S., Copeland, N., Jenkins, N., Price, D., Younkin, S., and Sisodia, S. (1996) Neuron 17, 1005-1013
5. Citron, M., Diehl, T., Gordon, G., Biere, A., Seubert, P., and Selkoe, D. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 13170-13175
6. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C., Perez-tur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996) Nature 383, 710-713
7. De Strooper, B., Saftig, P., Craessaerts, K., Vanderstichele, H., Guhde, G., Annaert, W., Von Figura, K., and Van Leuven, F. (1998) Nature 391, 387-390
8. Higaki, J., Quon, D., Zhong, Z., and Cordell, B. (1995) Neuron 14, 651-659
9. Klafki, H.-W., Abramowski, D., Swoboda, R., Paganetti, P. A., and Staufenbiel, M. (1996) J. Biol. Chem. 271, 28655-28659
10. Yamazaki, T., Haass, C., Saido, T. C., Omura, S., and Ihara, Y. (1997) Biochemistry 36, 8377-8383
11. Klafki, H. W., Paganetti, P. A., Sommer, B., and Staufenbiel, M. (1995) Neurosci. Lett. 201, 29-32
12. Hiwasa, T., Sawada, T., and Sakiyama, S. (1990) Carcinogenesis 11, 75-80
13. Viniski, A., Michaud, C., Powers, J., and Orlowski, M. (1992) Biochemistry 31, 9421-9428
14. Ida, N., Hartmann, T., Pantel, J., Schroder, J., Zerfass, R., Forstl, H., Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914
15. Savage, M. J., Trusko, S. P., Howland, D. S., Pinsker, L. R., Mistretta, S., Heaume, A. G., Greenberg, B. D., Siman, R., and Scott, R. W. (1998) J. Neurosci. 18, 1743-1752
16. Thinakaran, G., Borchelt, D. R., Lee, M. K., Slunt, H. H., Spitzer, L., Kim, G., Ratovitsky, T., Davenport, F., Nordstedt, C., Seeger, M., Hardy, J., Levey, A. I., Gandy, S. E., Jenkins, N. A., Copeland, N. G., Price, D. L., and Sisodia, S. S. (1996) Neuron 17, 181-190
17. Dykes, T., Dykes, E., Masters, C., and Beyreuther, K. (1992) FEBS Lett. 309, 20-24
18. Suzuki, N., Cheung, T., Cai, X., Odaka, A., Otvos, L., Jr., Eckman, C., Golde, T., and Younkin, S. (1994) Science 264, 1336-1340
19. Rogaev, E. I., Sherrington, R., Wu, C., Levesque, G., Liang, Y., Rogaeva, E. A., Ikeda, M., Holman, K., Lin, C., Lukiw, W. J., de Jong, P. J., Fraser, P. E., Rommens, J. M., and St George-Hyslop, P. (1997) Genomics 40, 415-424
20. Clark, R. F., and The Alzheimer's Disease Collaboration Group (1995) Nat. Genet. 11, 219-222
21. Dykes, T., Dykes, E., Monning, U., urmoneit, B., Turner, J., and Beyreuther, K. (1993) FEBS Lett. 335, 89-93
22. Marambaud, P., Ancolio, K., Lopez-Perez, E., and Checler, F. (1998) Mol. Med. 4, 147-157
23. Fraser, P. E., Levesque, G., Yu, G., Mills, L. R., Thirlwell, J., Frantseva, M., Gandy, S. E., Seeger, M., Carlen, P. L., and St. George-Hyslop, P. (1998) Neurobiol. Aging 19, 19-21