Loss of endosomal/lysosomal membrane impermeability is an early event in amyloid Aβ1-42 pathogenesis

Journal of Neuroscience Research

Volumn 52, Issue 6, 1998, Pages 691-698

  Yang, Austin J ^a   Chandswangbhuvana, Dhusdee ^a   Margol, Lawrence ^a   Glabe, Charles G ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Alzheimer's; Amyloid; Lysosomes

Indexed keywords

AMYLOID A PROTEIN; BETA N ACETYLHEXOSAMINIDASE; CATHEPSIN; HEPARAN SULFATE GLYCOSAMINOGLYCAN; HYDROLASE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; CONTROLLED STUDY; ENDOSOME; ENZYME RELEASE; HUMAN; HUMAN CELL; LYSOSOME; MEMBRANE PERMEABILITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION;

AMYLOID BETA-PROTEIN; CELL MEMBRANE PERMEABILITY; CYTOSOL; ENDOSOMES; FLUORESCENT ANTIBODY TECHNIQUE; FLUORESCENT DYES; HYDROLASES; ISOQUINOLINES; KINETICS; LYSOSOMES; PEPTIDE FRAGMENTS; TUMOR CELLS, CULTURED;

EID: 0032526652     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4547(19980615)52:6<691::AID-JNR8>3.0.CO;2-3     Document Type: Article

References (47)

1. Abe K, Kimura H (1996): Amyloid beta toxicity consists of a Ca(2+)-independent early phase and a Ca(2+)-dependent late phase. J Neurochem 67:2074-2078.
2. Behl C, Davis JB, Lesley R, Schubert D (1994): Hydrogen peroxide mediates amyloid beta protein toxicity. Cell 77:817-827.
3. Belichenko PV, Dahlstrom A (1994): Dual channel confocal laser scanning microscopy of lucifer yellow-microinjected human brain cells combined with Texas red immunofluorescence. J Neurosci Methods 52:111-118.
4. Burdick D, Kosmoski J, Knauer MF, Glabe CG (1997): Preferential adsorption, internalization and resistance to degradation of the major isoform of the Alzheimer's amyloid peptide, A β 1-42, in differentiated PC 12 cells. Brain Res 746:275-284.
5. Burdick D, Soreghan B, Kwon M, Kosmoski J, Knauer M, Henschen A, Yates J, Cotman C, Glabe C (1992): Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs. J Biol Chem 267:546-554.
6. Cabantchik ZI, Silfen J, Firestone RA, Krugliak M, Nissani E, Ginsburg H (1989): Effects of lysosomotropic detergents on the human malarial parasite Plasmodium falciparum in in vitro culture. Biochem Pharmacol 38:1271-1277.
7. Cataldo AM, Nixon RA (1990): Enzymatically active lysosomal proteases are associated with amyloid deposits in Alzheimer brain. Proc Natl Acad Sci USA 87:3861-3865.
8. Cataldo AM, Thayer CY, Bird E D, Wheelock TR, Nixon RA (1990): Lysosomal proteinase antigens are prominently localized within senile plaques of Alzheimer's disease: Evidence for a neuronal origin. Brain Res 513:181-192.
9. Cataldo AM, Barnett JL, Berman SA, Li J, Quarless S, Bursztajn S, Lippa C, Nixon RA (1995): Gene expression and cellular content of cathepsin D in Alzheimer's disease brain: Evidence for early up-regulation of the endosomal-lysosomal system. Neuron 14:671-680.
10. Cole M, Huynh TV, Saitoh T (1989): Evidence for lysosomal processing of amyloid beta-protein precursor in cultured cells. Neurochem Res 14:933-939.
11. Estus S, Golde TE, Kunishita T, Blades D, Lowery D, Eisen M, Usiak M, Qu XM, Tabira T, Greenberg BD, Younkin SG (1992): Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor. Science 255:726-728.
12. Forster S, Scarlett L, Lloyd JB (1987): The effect of lysosomotropic detergents on the permeability properties of the lysosome membrane. Biochim Biophys Acta 924:452-457.
13. Goedert M, Jakes R, Spillantini MG, Hasegawa M, Smith MJ, Crowther RA (1996): Assembly of microtubule-associated protein tau into Alzheimer-like filaments induced by sulphated glycosaminoglycans [see comments]. Nature 383:550-553.
14. Golde TE, Estus S, Younkin LH, Selkoe D J, Younkin SG (1992): Processing of the amyloid protein precursor to potentially amyloidogenic derivatives [see comments]. Science 255:728-730.
15. Gregori L, Bhasin R, Goldgaber D (1994): Ubiquitin-mediated degradative pathway degrades the extracellular but not the intracellular form of amyloid beta-protein precursor. Biochem Biophys Res Commun 203:1731-1738.
16. Gregori L, Hainfeld JF, Simon M N, Goldgaber D (1997): Binding of amyloid beta protein to the 20 S proteasome. J Biol Chem 272: 58-62.
17. Haass C, Koo EH, Mellon A, Hung AY, Selkoe DJ (1992): Targeting of cell-surface beta-amyloid precursor protein to lysosomes: Alternative processing into amyloid-bearing fragments. Nature 357: 500-503.
18. Ida N, Masters L, Beyreuther K (1996): Rapid cellular uptake of Alzheimer amyloid betaA4 peptide by cultured human neuroblastoma cells. FEBS Lett 394:174-178.
19. Iozzo RV (1987): Turnover of heparan sulfate proteoglycan in human colon carcinoma cells. A quantitative biochemical and autoradiographic study. J Biol Chem 262:1888-1900.
20. Knauer MF, Soreghan, B, Burdick D, Kosmoski J, Glabe CG (1992): Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/beta protein. Proc Natl Acad Sci USA 89:7437-7441.
21. Lambert MP, Stevens G, Sabo S, Barber K, Wang G, Wade W, Krafft G, Snyder S, Holzman TF, Klein WL (1994): Beta/A4-evoked degeneration of differentiated SH-SY5Y human neuroblastoma cells. J Neurosci Res 39:377-385.
22. Li YP, Bushnell AF, Lee CM, Perlmutter LS, Wong SK (1996): Beta-amyloid induces apoptosis in human-derived neurotypic SH-SY5Y cells. Brain Res 738:196-204.
23. Lomakin A, Chung DS, Benedek GB, Kirschner DA, Teplow DB (1996): On the nucleation and growth of amyloid beta-protein fibrils: Detection of nuclei and quantitation of rate constants. Proc Natl Acad Sci USA 93:1125-1129.
24. Loo DT, Copani A, Pike CJ, Whittemore ER, Walencewicz AJ, Cotman C W (1993): Apoptosis is induced by beta-amyloid in cultured central nervous system neurons. Proc Natl Acad Sci USA 90:7951-7955.
25. Lorenzo A, Yankner BA (1994): Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red. Proc Natl Acad Sci USA 91:12243-12247.
26. Martin LJ, Pardo CA, Cork LC, Price DL (1994): Synaptic pathology and glial responses to neuronal injury precede the formation of senile plaques and amyloid deposits in the aging cerebral cortex. Am J Pathol 145:1358-1381.
27. Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D (1996): Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 16:5795-5811.
28. May PC, Gitter BD, Waters DC, Simmons LK, Becker GW, Small JS, Robison PM (1992): beta-Amyloid peptide in vitro toxicity: Lot-to-lot variability. Neurobiol Aging 13:605-607.
29. Miller DK, Griffiths E, Lenard J, Firestone RA (1983): Cell killing by lysosomotropic detergents. J Cell Biol 97:1841-1851.
30. Nixon RA, Cataldo AM, Paskevich PA, Hamilton DJ, Wheelock TR, Kanaley-Andrews L (1992): The lysosomal system in neurons. Involvement at multiple stages of Alzheimer's disease pathogenesis. Ann N Y Acad Sci 674:65-88.
31. Perry G, Siedlak SL, Richey P, Kawai M, Cras P, Kalaria RN, Galloway PG, Scardina JM, Cordell B, Greenberg BD, Ledbetter SR, Gambetti P (1991): Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease. J Neurosci 11:3679-3683.
32. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991a): Aggregation-related toxicity of synthetic beta-amyloid protein in hippocampal cultures. Eur J Pharmacol 207:367-368.
33. Pike CJ, Walencewicz AJ, Glabe CG, Cotman CW (1991b): In vitro aging of beta-amyloid protein causes peptide aggregation and neurotoxicity. Brain Res 563:311-314.
34. Pike CJ, Burdick D, Walencewicz AJ, Glabe CG, Cotman CW (1993): Neurodegeneration induced by beta-amyloid peptides in vitro: The role of peptide assembly state. J Neurosci 13:1676-1687.
35. Selkoe DJ (1994): Normal and abnormal biology of the beta-amyloid precursor protein. Annu Rev Neurosci 17:489-517.
36. Shearman MS (1996): Cellular MTT reduction distinguishes the mechanism of action of beta-amyloid from that of tachykinin receptor peptides. Neuropeptides 30:125-132.
37. Snow AD, Mar H, Nochlin D, Kresse H, Wight TN (1992): Peripheral distribution of dermatan sulfate proteoglycans (decorin) in amyloid-containing plaques and their presence in neurofibrillary tangles of Alzheimer's disease. J Histochem Cytochem 40:105-113.
38. Snow AD, Mar H, Nochlin D, Sekiguchi RT, Kimata K, Koike Y, Wight TN (1990): Early accumulation of heparan sulfate in neurons and in the beta-amyloid protein-containing lesions of Alzheimer's disease and Down's syndrome. Am J Pathol 137:1253-1270.
39. Soreghan B, Kosmoski J, Glabe C (1994): Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation. J Biol Chem 269:28551-28554.
40. Su JH, Cummings BJ, Cotman CW (1992): Localization of heparan sulfate glycosaminoglycan and proteoglycan core protein in aged brain and Alzheimer's disease. Neuroscience 51:801-813.
41. Swanson J, Burke E, Silverstein SC (1987): Tubular lysosomes accompany stimulated pinocytosis in macrophages. J Cell Biol 104: 1217-1222.
42. Tabaton M, Cammarata S, Mancardi G, Manetto V, Autilio-Gambetti L, Perry G, Gambetti P (1991): Ultrastructural localization of beta-amyloid, tau, and ubiquitin epitopes in extracellular neurofibrillary tangles. Proc Natl Acad Sci USA 88:2098-2102.
43. Watt JA, Pike CJ, Walencewicz-Wasserman AJ, Cotman CW (1994): Ultrastructural analysis of beta-amyloid-induced apoptosis in cultured hippocampal neurons. Brain Res 661:147-156.
44. Wilson PD, Firestone RA, Lenard J (1987): The role of lysosomal enzymes in killing of mammalian cells by the lysosomotropic detergent N-dodecylimidazole. J Cell Biol 104:1223-1229.
45. Wisniewski HM, Frackowiak J, Mazur-Kolecka B (1995): In vitro production of beta-amyloid in smooth muscle cells isolated from amyloid angiopathy-affected vessels. Neurosci Lett 183: 120-123.
46. Yanagishita M, Hascall VC (1987): Biology of the proteoglycans. In Wright T, Mecham R (eds):"Biology of the Proteoglycans." Academic Press, pp 105-128.
47. Yang AJ, Knauer M, Burdick DA, Glabe C (1995): Intracellular A β 1-42 aggregates stimulate the accumulation of stable, insoluble amyloidogenic fragments of the amyloid precursor protein in transfected cells. J Biol Chem 270:14786-14792.