The deletion of the C-terminal tail and addition of an endoplasmic reticulum targeting signal to Alzheimer's amyloid precursor protein change its localization, secretion, and intracellular proteolysis

European Journal of Biochemistry

Volumn 258, Issue 2, 1998, Pages 291-300

  Kouchi, Zen ^a   Kinouchi, Tadatoshi ^a,b   Sorimachi, Hiroyuki ^a   Ishiura, Shoichi ^a   Suzuki, Koichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Amyloid precursor protein; ER retrieval signal; Proteolysis; Sorting

Indexed keywords

AMYLOID PRECURSOR PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; ENDOPLASMIC RETICULUM; MONKEY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TARGETING;

ADENOVIRUS EARLY PROTEINS; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BIOTINYLATION; BREFELDIN A; CHLOROQUINE; COS CELLS; ENDOPLASMIC RETICULUM; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; KINETICS; MICROSCOPY, FLUORESCENCE; MONENSIN; PROTEIN SORTING SIGNALS; RECOMBINANT FUSION PROTEINS; TRANSFECTION;

ANIMALIA;

EID: 0032401578     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1998.2580291.x     Document Type: Article

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