Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons

Journal of Cell Biology

Volumn 135, Issue 4, 1996, Pages 1085-1096

  Slack, Ruth S ^a   Belliveau, Daniel J ^a   Rosenberg, Madelaine ^a   Atwal, Jasvinder ^a   Lochmüller, Hanns ^b   Aloyz, Raquel ^a   Haghighi, Ali ^a   Lach, B ^c   Seth, Prem ^d   Cooper, Ellis ^a   Miller, F D ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c UNIVERSITY OF OTTAWA   (Canada)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; CYTOARCHITECTURE; ETIOLOGY; EXPRESSION VECTOR; GENE TRANSFER; GENETIC MANIPULATION; GENETIC TRANSDUCTION; MITOSIS; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; PRIORITY JOURNAL; RAT; SYMPATHETIC NERVE CELL; TUMOR SUPPRESSOR GENE; VIRUS RECOMBINANT;

ADENOVIRIDAE; ANIMALIA;

EID: 10544249872     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.135.4.1085     Document Type: Article

References (43)

1. Bacchetti, S., and F.L. Graham. 1993. Inhibition of cell proliferation by an adenovirus vector expressing the human wild-type p53 protein. Int. J. Oncol. 3:781-788.
2. Bett, A.J., W. Haddara, L. Prevec, and F.L. Graham. 1994. An efficient and flexible system for construction of adenovirus vectors with insertions or deletions in early regions 1 and 3. Proc. Natl. Acad. Sci. USA. 91:8802-8806.
3. Boviatsis, E.J., M. Chase, M.X. Wei, T. Tamiya, R.K. Hurford, N.W. Kowall. R.I. Tepper, X.O. Breakefield, and E.A. Chiocca. 1994. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, retrovirus vectors. Hum. Gene Ther. 5:183-191.
4. Caelles, C., A. Helmberg, and M. Karin. 1994. p53-dceendent apoptosis in the absence of transcriptional activation of p53 target genes. Nature (Lond.). 370:220-223.
5. Davies, A.M. and A. Rosenthal. 1994. Neurons from mouse embryos with a null mutation in the tumour suppressor gene p53 undergo normal cell death in the absence of neurotrophins. Neurosci. Lett. 182:112-114.
6. Deckwerth, T.L., and E.M. Johnson. 1993. Temporal analysis of events associated with programmed cell death (apoptosis) of sympathetic neurons deprived of nerve growth factor. J. Cell Biol. 123:1207-1222.
7. Donehower, L.A., M. Harvey, B.L. Slagle, M.J. McArthur, and C.A. Montgomery. 1992. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature (Lond.). 356:215-221.
8. Dou, Q-P., J.L. Fridovich-Keil, and A.B. Pardee. 1991. Inducible proteins binding to the murine thymidine kinase promoter in late Gl/S phase. Proc. Natl. Acad. Sci. USA. 88:1157-1161.
9. Dutta, A., J.M. Ruppert, J.C. Aster, and E. Winchester. 1993. Inhibition of DNA replication factor RPA by p53. Nature (Lond.). 365:79-82.
10. El-Deiry, W.S., S.E., Kern, J.A. Pietenpol, K.W. Kinzler, and B. Vogelstein. 1992. Definition of a consensus binding site for p53. Nat. Genet. I: 45-49.
11. El-Deiry, W.S., T. Tokino, V.E. Velculescu, D.B. Levy, R. Parsons, J.M. Trent, D. Lin, E. Mercer, K.W. Kinzler, and B. Vogelstein. 1993. WAFI, a potential mediator of p53 tumor suppression. Cell. 75:817-825.
12. Elledge, R.M., and W-H. Lee. 1995. Life and death by p53. Bioessays. 17: 923-930.
13. Freeman, R.S., S. Estus, and E.M. Johnson. 1994. Analysis of cell cycle related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron. 12:343-355.
14. Graham, F.L., and L. Prevec. 1991. Manipulation of adenovirus vectors. In Methods in Molecular Biology. E.J. Murray, editor. The Humana Press, Totowa, NJ. 109-128.
15. Harper, J.W., G.R. Adami, N. Wei, K. Keyomarsi, and S.I. Elledge. 1993. The p21 cdk-interacting protein eipl is potent inhibitor of G1 cyclin-dependent kinases. Cell. 75:805-816.
16. Ho, D.Y., and E.S. Mocarski. 1988. Beta-galactosidase as a marker in the peripheral and nervous tissues of the herpes simplex virus-infected mouse. Virology. 174:279-283.
17. Hockenbery, D., G. Nunes, C. Millinian, R.D. Shreiker, and S.J. Korsemeyer. 1990. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (Lond.). 348:334-336.
18. Katayose, D., R. Wersto, K.H. Cowan, and P. Seth. 1995. Effects of a recombinant adenovirus expressing WAF1/Cip1 on cell growth, cell cycle and apoptosis. Cell Growth Differ. 6:1207-1212.
19. Lane, D.P. 1993. A death in the life of p53. Nature (Lond.). 362:786-787.
20. Le Gal La Salle, G., J.J. Robert, S. Berrard, V. Ridoux, L.D. Stratford-Perricaudet. M. Perricaudet, and J. Mallet. 1993. An adenovirus vector for gene transfer into neurons and glia in the brain. Science (Wash. DC). 259: 988-990.
21. Li, R., and M.R. Botchan. 1993. The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell. 73:1207-1221.
22. Li, Y., M. Chopp, Z.G. Zhang, C. Zaloga, L. Niewenhuis, and S. Gautam. 1994. p53-immunoreactive protein and p53 mRNA expression after transient middle cerebral artery occlusion in rats. Stroke. 25:849-856.
23. Lipson, K.E., S.T. Chen, J. Koniecki, D.H. Ku, and R. Baserga. 1989. S-phase specific regulation by deletion mutants of the human thymidine kinase promoter. Proc. Natl. Acad. Sci. USA. 86:6848-6852.
24. Lochmüller, H., A. Jani, J. Huard, S. Prescott, M. Simoneau, B. Massie, G. Karpati, and G. Acsadi. 1994. Emergence of early region 1-containing replication-competent adenovirus in stocks of replication-defective adenovirus recombinants during multiple passages in 293 cells. Hum. Gene Ther. 5:1485-1491.
25. Ma, Y., R.B. Campenot, and F.D. Miller. 1992. Concentration-dependent regulation of neuronal gene expression by nerve growth factor. J. Cell Biol. 117:135-141.
26. McFarlane, S., and E. Cooper. 1992. Postnatal development of voltage-gated K currents in rat sympathetic neurons. J. Neurophys. 67:1291-1300.
27. McFarlane, S., and E. Cooper. 1993. Extrinsic factors influence the expression of voltage-gated K currents in neonatal rat sympathetic neurons. J. Neurosci. 13:2591-2600.
28. Miyashita, T., and J.C. Reed. 1995. p53 is a direct transcriptional activator of the human bax gene. Cell. 80:293-299.
29. Miyashita, T., S. Krajewski, M. Krajewska, H.G. Wang, H.K. Lin, D.A. Liebermann, B. Hoffman, and J.C. Reed. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 9:1799-1805.
30. Oltvai, Z.N., C.L. Milliman, and S.J. Korsmeyer. 1993. Bcl-2 heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death. Cell. 746:609-619.
31. Oppenheim. R.W. 1991. Cell death during development of the nervous system. Annu. Rev. Neurosci. 14:453-501.
32. Owen-Schaub, L., W. Zhang, J.C. Cusack, L.S. Angelo, S.M. Santee, T. Fujiwara, J.A. Roth, A.B. Deisseroth, W-W. Zhang, E. Kruzel, and R. Radinsky. 1995. Wild-type human p53 and a temperature-sensitive mutant induce Fas/Apo-1 expression. Mol. Cell. Biol. 15:3032-3040.
33. Picksley, S.M., and D.P. Lane. 1994. p53 and Rb: their cellular roles. Curr. Opin. Cell Biol. 6:853-858.
34. Pietenpol, J.A., T. Tokino, S. Thiagalingam, W.S. El-Deiry, K.W. Kinzler, and B. Vogelslein. 1994. Sequence-specific transcriptional activation is essential for growth suppression by p53. Prof. Natl. Acad. Sci. USA. 91: 1998-2002.
35. Sabbatini, P., J. Lin, A.J. Levine, and E. White. 1995. Essential role for p53-mediated transcription in apoptosis but not growth suppression. Genes & Dev. 9:2184-2192.
36. Sakhi, S., A. Bruce, N. Sun, G. Tocco, and M. Baudry. 1994. p53 induction is associated with neuronal damage in the central nervous system. Proc. Null. Acad. Sci. USA. 91:7525-7529.
37. Sherley, J.L., and T.J. Kelly. 1988. Regulation of human thymidine kinase during the cell cycle. J. Biol. Chem. 263:8350-8358.
38. Silos-Santiago, I., L.J.S. Greenlund, E.M. Johnson, and W.D. Snider. 1995. Molecular genetics of neuronal survival. Curr. Opin. Neurobiol. 5:42-49.
39. Slack, R.S., and F.D. Miller. 1996. Viral vectors for use in modulating gene expression in neurons. Curr. Opin. Neurobiol. 6:576-583.
40. Slack, R.S., I.S. Skerjanc, B. Lach, J. Craig, K. Jardine, and M. W. McBurney. 1995. Cells differentiating into neuroectoderm undergo apoptosis in the absence of functional retinoblastoma family proteins. J. Cell Biol. 129:779-788.
41. White, E. 1996. Life, death, and the pursuit of apoptosis. Genes & Dev. 10: 1-15.
42. Wood, K.A., and R.J. Youle. 1995. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:5851-5857.
43. Xiong, Y., G. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature (Lond.). 366: 701-704.