The β-Amyloid Precursor Protein Functions as a Cytosolic Anchoring Site That Prevents Fe65 Nuclear Translocation

Journal of Biological Chemistry

Volumn 276, Issue 9, 2001, Pages 6545-6550

  Minopoli, Giuseppina ^b   De Candia, Paola ^b   Bonetti, Alessandro ^b   Faraonio, Raffaella ^b   Zambrano, Nicola ^b   Russo, Tommaso ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IRON; MUTAGENESIS;

NUCLEAR TRANSLOCATIONS;

PROTEINS;

ADAPTOR PROTEIN; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; PROTEIN FE65; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; APBB1 PROTEIN, RAT; HYBRID PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CYTOSOL; GENE EXPRESSION; IMMUNOPRECIPITATION; NEUROLOGIC DISEASE; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; WESTERN BLOTTING; ACTIVE TRANSPORT; ANIMAL; CELL MEMBRANE; CELL STRAIN; CELL STRAIN COS1; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; METABOLISM; PHYSIOLOGY; RAT; TRANSPORT AT THE CELLULAR LEVEL;

ANIMALIA; VECTORS;

ACTIVE TRANSPORT, CELL NUCLEUS; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; BIOLOGICAL TRANSPORT; CELL MEMBRANE; COS CELLS; CYTOSOL; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PC12 CELLS; RATS; RECOMBINANT FUSION PROTEINS;

EID: 0035794182     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007340200     Document Type: Article

References (53)

1. Selkoe, D. J. (1999) Nature 369, A23-A31
2. Koo, E. H., Squazzo, S. L., Selkoe, D. J., and Koo, C. H. (1996) J. Cell Sci. 109, 991-998
3. Sambamurti, K., Shioi, J., Anderson, J. P., Pappola, M. A., and Robakis, N. K. (1992) J. Neurosci. Res. 33, 319-329
4. Lammich, S., Kojro, E., Postina, R., Gilbert, S., Pfeiffer, R., Jasionowski, M., Haass, C., and Fahrenholz, F. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3922-3927
5. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., and Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856
6. Perez, R. J., Squazzo, S. L., and Koo, E. H. (1996) J. Biol. Chem. 271, 9100-9107
7. Hussain, I., Powell, D., Howlett, D. R., Tew, D. G., Meek, T. D., Chapman, C., Gloger, I. S., Murphy, K. E., Southan, C. D., Ryan, D. M., Smith, T. S., Simmons, D. L., Walsh, F. S., Dingwall, C., and Christie, G. (1999) Mol. Cell. Neurosci. 14, 419-427
8. Sinha, S., Anderson, J. P., Barbour, R., Basi, G. S., Caccavello, R., Davis, D., Doan, N., Dovey, H. F., Frigon, N., Hong, J., Jacobson-Croak, K., Jewett, N., Keim, P., Knops, J., Lieberburg, I., Power, M., Tan, H., Tatsuno, G., Tung, J., Schenk, D., Seubert, P., Suomensaari, S. M., Wang, S., Walker, D., John, V., et al. (1999) Nature 402, 537-540
9. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lile, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J.-C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
10. Yan, R., Bienkowski, M. J., Shuck, M. E., Miao, H., Tory, M. C., Pauley, A. M., Brashier, J. R., Stratmen, N. C., Mathews, W. R., Buhl, A. E., Carter, D. B., Tomasselli, A. G., Parodi, L. A., Heinrikson, R. L., and Gurney, M. E. (1999) Nature 398, 525-529
11. Esler, W. P., Kimberly, W. T., Ostaszewski, B. L., Diel, T. S., Moore, C. L., Tsai, J.-Y., Rahmati, T., Xia, W., Selkoe, D. J., and Wolfe, M. S. (2000) Nat. Cell Biol. 2, 428-434
12. De Strooper, B., Annaert, W., Cupers, P., Saftig, P., Craessaert, K., Mumm, J. S., Schroetter, E. H., Schrijvers, V., Wolfe, M. S., Ray, W. J., Goate, A., and Kopan, R. (1999) Nature 398, 518-522
13. Russo, T., Faraonio, R., Minopoli, G., De Candia, P., De Renzis, S., and Zambrano, N. (1998) FEBS Lett. 434, 1-7
14. De Strooper, B., and Annaert, W. (2000) J. Cell Sci. 113, 1857-1870
15. Simeone, A., Duilio, A., Fiore, F., Acampora, D., De Felice, C., Faraonio, R., Paolocci, F., Cimino, F., and Russo, T. (1994) Dev. Neurosci. 16, 53-60
16. Duilio, A., Zambrano, N., Mogavero, A. R., Ammendola, R., Cimino, F., and Russo, T. (1991) Nucleic Acids Res. 19, 5269-5274
17. Guenette, S. Y., Chen, J., Jondro, P. D., and Tanzi, R. E. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 10832-10837
18. Duilio, A., Faraonio, R., Minopoli, G., Zambrano, N., and Russo, T. (1998) Biochem. J. 330, 513-519
19. Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., and Russo, T. (1995) J. Biol. Chem. 270, 30853-30856
20. Borg, J. P., Ooi, J., Levy, E., and Margolis, B. (1996) Mol. Cell. Biol. 16, 6229-6241
21. Bressler, S. L., Gray, M. D., Sopher, B. L., Hu, Q. B., Hearn, M. G., Pham, D. G., Dinulos, M. B., Fukuchi, K. I., Sisodia, S. S., Miller, M. A., Disteche, C. M., and Martin, G. M. (1996) Hum. Mol. Genet. 5, 1589-1598
22. Zambrano, N., Buxbaum, J. D., Minopoli, G., Fiore, F., De Candia, P., De Renzis, S., Faraonio, R., Sabo, S., Cheetham, J., Sudol, M., and Russo, T. (1997) J. Biol. Chem. 272, 6399-6405
23. McLoughlin, D. M., and Miller, C. C. J. (1996) FEBS Lett. 397, 197-200
24. Tanahashi, H., and Tabira, T. (1999) Biochem. Biophys. Res. Commun. 255, 663-667
25. Tomita, S., Ozaki, T., Taru, H., Oguchi, S., Takeda, S., Yagi, Y., Sakiyama, S., Kirino, Y., and Suzuki, T. (1999) J. Biol. Chem. 274, 2243-2254
26. Homayouni, R., Rice, D. S., Sheldon, M., and Curran, T. (1999) J. Neurosci. 19, 7507-7515
27. Trommsdorff, M., Borg, J. P., Margolis, B., and Herz, J. (1998) J. Biol. Chem. 273, 33556-33560
28. Sabo, S. L., Lanier, L. M., Ikin, A. F., Khorkova, O., Sahasrabudhe, S., Greengard, P., and Buxbaum, J. D. (1999) J. Biol. Chem. 274, 7952-7957
29. Guenette, S. Y., Chen, J., Ferland, A., Haas, C., Capell, A., and Tanzi, R. E. (1999) J. Neurochem. 73, 985-993
30. Borg, J. P., Yang, Y. N., De Taddéo-Borg, M., Margolis, B., and Turner, R. S. (1998) J. Biol. Chem. 273, 14761-14766
31. Sastre, M., Turner, R. S., and Levy, E. (1998) J. Biol. Chem. 273, 22351-22357
32. Nishimoto, I., Okamoto, T., Matsuura, Y., Takahashi, S., Okamoto, T., Murayama, Y., and Ogata, E. (1993) Nature 362, 75-79
33. Zheng, P., Eastman, J., Vande Pol, S., and Pimplikar, S. W. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 14745-14750
34. Chow, N., Koremberg, J. R., Chen, X.-N., and Neve, R. L. (1996) J. Biol. Chem. 271, 11339-11346
35. Ermekova, K.-S., Zambrano, N., Linn, H., Minopoli, G., Gertler, F., Russo, T., and Sudol, M. (1997) J. Biol. Chem. 272, 32869-32874
36. Zambrano, N., Minopoli, G., De Candia, P., and Russo, T. (1998) J. Biol. Chem. 273, 20128-20133
37. Borg, J. P., Straight, S. W., Kaech, S. M., de Taddéo-Borg, M., Kroon, D. E., Karnak, D., Turner, R. S., Kim, S. K., and Margolis, B. (1998) J. Biol. Chem. 273, 31633-31636
38. Borg, J. P., Lopez-Figueroa, M. O., de Taddeo-Borg, M., Kroon, D. E., Turner, R. S., Watson, S. J., and Margolis, B. (1998) J. Neurosci. 19, 1307-1316
39. Butz, S., Okamoto, M., and Sudhof, T. C. (1998) Cell 94, 773-782
40. McLoughlin, D. M., Irving, N. G., Brownlees, J., Brion, J. P., Leroy, K., and Miller, C. C. (1999) Eur. J. Neurosci. 11, 1988-1994
41. Maximov, A., Sudhof, T. C., and Bezprozvanny, I. (1999) J. Biol. Chem. 274, 24453-24456
42. Manier, L. M., Gates, M. A., Witke, W., Menzies, A. S., Wehman, A. M., Macklis, J. D., Kwiatkowski, D., Soriano, P., and Gertler, F. B. (1999) Neuron 22, 313-325
43. Faraonio, R., Minopoli, G., Porcellini, A., Costanzo, F., Cimino, F., and Russo, T. (1994) Nucleic Acids Res. 22, 4876-4883
44. Kaffman, A., and O'Shea, E. K. (1999) Annu. Rev. Cell Dev. Biol. 15, 291-339
45. Kong, M., Barnes, E. A., Ollendorff, V., and Donoghue, D. J. (2000) EMBO J. 19, 1378-1388
46. Brown, J. D., and Moon, T. T. (1998) Curr. Opin. Cell Biol. 10, 182-187
47. Kemler, R. (1993) Trends Genet. 9, 317-321
48. Behrens, J., von Kries, J. P., Kuhl, M., Bruhn, L., Wedlich, D., Grosschedl, R., and Birchmeier, W. (1996) Nature 382, 638-642
49. Fagotto, F., Funayama, N., Gluck, U., and Grumbiner, B. M. (1996) J. Cell Biol. 132, 1105-1114
50. Fagotto, F., Gluck, U., and Grumbiner, B. M. (1998) Curr. Biol. 8, 181-190
51. Artavanis-Tsakonas, S., Rand, M. D., and Lake, R. J. (1999) Science 284, 770-776
52. Brown, M. S., and Goldstein, J. L. (1997) Cell 89, 331-340
53. Lambert, J. C., Goumidi, L., Vrieze, F. W., Frigard, B., Harris, J. M., Cummings, A., Coates, J., Pasquier, F., Cottel, D., Gaillac, M., St. Clair, D., Mann, D. M., Hardy, J., Lendon, C. L., Amouyel, P., and Chartier-Harlin, M. C. (2000) Hum. Mol. Genet. 9, 2275-2280