Abortive apoptosis in Alzheimer's disease

Acta Neuropathologica

Volumn 101, Issue 4, 2001, Pages 305-310

  Raina, Arun K ^a   Hochman, Ayala ^b   Zhu, Xiongwei ^a   Rottkamp, Catherine A ^a   Nunomura, Akihiko ^c   Siedlak, Sandra L ^a   Boux, Heather ^d   Castellani, Rudolph J ^a   Perry, George ^a   Smith, Mark A ^a  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b TEL AVIV UNIVERSITY   (Israel)

^c ASAHIKAWA MEDICAL COLLEGE   (Japan)

^d Stressgen Biotechnologies Co   (Canada)

Author keywords

Alzheimer disease; Apoptosis; Caspases; Neurofibrillary pathology; Neuronal survival

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CASPASE; CASPASE 3; CASPASE 6; CASPASE 7; CASPASE 8; CASPASE 9; DNA; PRESENILIN 1; PRESENILIN 2;

ADULT; AGED; ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CELL SURVIVAL; CHROMATIN CONDENSATION; CLINICAL ARTICLE; CONTROLLED STUDY; DNA FLANKING REGION; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; HUMAN CELL; HUMAN TISSUE; NERVE CELL NECROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN PROCESSING; REGULATORY MECHANISM; SIGNAL TRANSDUCTION;

ADULT; AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; APOPTOSIS; CASPASES; FEMALE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; NEUROFIBRILLARY TANGLES; NEURONS; TEMPORAL LOBE;

EID: 0035027964     PISSN: 00016322     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004010100378     Document Type: Article

References (39)

1. DNA damage and apoptosis in Alzheimer's disease: Colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmorten delay
2. Mechanisms of cell death in Alzheimer's disease
3. Caspases: The executioners of apoptosis
4. Mechanisms of neuronal death in Alzheimer's disease
5. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells
6. Redox regulation of the caspases during apoptosis
7. Neuropathology of Alzheimer's disease: A critical update
8. Diagnosis of Alzheimer's disease
9. Cell death in Alzheimer's disease evaluated by DNA fragmentation in situ
10. Caspase-6 role in apoptosis of human neurons, amyloidogenesis, and Alzheimer's disease
11. Microwave-enhanced in situ end-labeling of fragmented DNA: Parametric studies in relation to postmortem delay and fixation of rat and human brain
12. DNA damage distribution in the human brain as shown by in situ end labeling; area-specific differences in aging and Alzheimer disease in the absence of apoptotic morphology
13. A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide
14. Phosphorylated forms of activated caspases are present in cytosol from HL-60 cells during etoposide-induced apoptosis
15. The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer's disease
16. Neurons may live for decades with neurofibrillary tangles
17. Apoptosis and Alzheimer's disease
18. A suicide note from Alzheimer disease neurons?
19. Estrogen modulates neuronal Bcl-xL expression and beta-amyloid-induced apoptosis: Relevance to Alzheimer's disease
20. L in developmental programmed cell death
21. Caspase activation: The induced proximity model
22. 4-Hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer's disease
23. In situ immunodetection of neuronal caspase-3 activation in Alzheimer disease
24. Progressive neuronal injury associated with amyloid plaque formation in Alzheimer disease
25. Progressive neuronal DNA damage associated with neurofibrillary tangle formation in Alzheimer disease
26. Signalling mechanisms and oxidative stress in apoptosis
27. Oxidative damage in Alzheimer's
28. Widespread peroxynitrite-mediated damage in Alzheimer's disease
29. An alternative, nonapoptotic form of programmed cell death
30. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis
31. Activation of caspase-3 in single neurons and autophagic granules of granulovacuolar degeneration in Alzheimer's disease
32. Pro-caspase-3 is a major physiologic target of caspase-8
33. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain
34. GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro
35. DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines
36. Research communication copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical
37. Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival
38. New clues to Alzheimer's disease: Unraveling the roles of amyloid and tau