γ-secretase cleavage site specificity differs for intracellular and secretory amyloid β

Journal of Biological Chemistry

Volumn 278, Issue 15, 2003, Pages 13077-13085

  Grimm, Heike S ^a   Beher, Dirk ^b   Lichtenthaler, Stefan F ^c   Shearman, Mark S ^b   Beyreuther, Konrad ^a   Hartmann, Tobias ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c UNIVERSITY OF MUNICH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MEMBRANES; CELLS;

AMYLOID PRECURSOR PROTEINS;

PROTEINS;

AMYLOID BETA PROTEIN; CELL PROTEIN; GAMMA SECRETASE; MUTANT PROTEIN; PRESENILIN 1; PRESENILIN 2; SECRETORY PROTEIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; PROTEINASE; RECOMBINANT PROTEIN; SECRETASE;

ARTICLE; CANCER CELL CULTURE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; GOLGI COMPLEX; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; POINT MUTATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN SECRETION; PROTEIN STRUCTURE; AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; CELL CULTURE; CHEMISTRY; ENZYME SPECIFICITY; GENETIC TRANSFECTION; GENETICS; KINETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NEUROBLASTOMA; SECRETION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; CLONING, MOLECULAR; ENDOPEPTIDASES; HUMANS; KINETICS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NEUROBLASTOMA; POINT MUTATION; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0038037751     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M210380200     Document Type: Article

References (86)

1. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., Simms, G., Weinman, N. A., Multhaup, G., McDonald, B. L., and Beyreuther, K. (1985) Proc. Natl. Acad. Sci. U. S. A. 82, 4245-4249
3. Kang, J., Lemaire, H. G., Unterbeck, A., Salbaum, J. M., Masters, C. L., Grzechik, K. H., Multhaup, G., Beyreuther, K., and Mueller-Hill, B. (1987) Nature 325, 733-736
4. Esler, W. P., and Wolfe, M. S. (2001) Science 293, 1449-1454
5. Haass, C., Schlossmacher, M. G., Hung, A. Y., Vigo-Pelfrey, C., Mellon, A., Ostaszewski, B. L., Lieberburg, I., Koo, E. H., Schenk, D., Teplow, D. B., and Selkoe, D. J. (1992) Nature 359, 322-325
6. Seubert, P., Vigo-Pelfrey, C., Esch, F., Lee, M., Dovey, H., Davis, D., Sinha, S., Schlossmacher, M., Whaley, J., Swindlehurst, C., McCormack, R., Wolfert, R., Selkoe, D., Lieberburg, I., and Schenk, D. (1992) Nature 359, 325-327
7. Shoji, M., Golde, T. E., Ghiso, J., Cheung, T. T., Estus, S., Shaffer, L. M., Cai, X. D., McKay, D. M., Tintner, R., Frangione, B., and Younkin, S. G. (1992) Science 258, 126-129
8. De Strooper, B., and Annaert, W. (2000) J. Cell Sci, 113, 1857-1870
9. Yu, G., Chen, F., Levesque, G., Nishimura, M., Zhang, D. M., Levesque, L., Rogaeva, E., Xu, D., Liang, Y., Duthie, M., St George-Hyslop, P. H., and Fraser, P. E. (1998) J. Biol. Chem. 273, 16470-16475
10. Li, Y. M., Lai, M. T., Xu, M., Huang, Q., Di Muzio-Mower, J., Sardana, M. K., Shi, X. P., Yin, K. C. Shafer, J. A., and Gardell, S. J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 6138-6143
11. Yu, G., Nishimura, M., Arawaka, S., Levitan, D., Zhang, L., Tandon, A., Song, Y. Q., Rogaeva, E., Chen, F., Kawarai, T., Supala, A., Levesque, L., Yu, H., Yang, D. S., Holmes, E., Milman, P., Liang, Y., Zhang, D. M., Xu, D. H., Sato, C., Rogaev, E., Smith, M., Janus, C., Zhang, Y., Aebersold, R., Farrer, L., Sorbi, S., Bruni, A., Fraser, P., and St George-Hyslop, P. (2000) Nature 407, 48-54
12. Edbauer, D., Winkler, E., Haass, C., and Steiner, H. (2002) Proc. Natl. Acad. Sci, U. S. A. 99, 8666-8671
13. Francis, R., Mc Grath, G., Zhang, J., Ruddy, D. A., Sym, M., Apfeld, J., Nicoll, M., Maxwell, M., Hai, B., Ellis, M. C., Parks, A. L., Xu, W., Li, J., Gurney, M., Myers, R. L., Himers, C. S., Hiebsch, R., Ruble, C., Nye, J. S., and Curtis, D. (2002) Dev. Cell 3, 85-97
14. Kovacs, D. M., Fausett, H. J., Page, K. J., Kim, T. W., Moir, R. D., Merriam, D. E., Hollister, R. D., Hallmark, O. G., Mancini, R., Felsenstein, K. M., Hyman, B. T., Tanzi, R. E., and Wasco, W. (1996) Nat. Med. 2, 224-229
15. Culvenor, J. G., Maher, F., Evin, G., Malchiodi-Albedi, F., Cappai, R., Underwood, J. R., Davis, J. B., Karran, E. H., Roberts, G. W., Beyreuther, K., and Masters, C. L. (1997) J. Neurosci. Res. 49, 719-731
16. Annaert, W. G., Levesque, L., Craessarts, K., Dierinck, I., Snellings, G., Westaway, D., St. George-Hyslop, P., Cordell, B., Fraser, P., and De Strooper, B. (1999) J. Cell Biol. 147, 277-294
17. Cupers, P., Bentahir, M., Craessaerts, K., Orlans, I., Vanderstichele, H., Saftig, P., De Strooper, B., and Annaert, W. (2001) J. Cell Biol. 154, 731-740
18. Selkoe, D. J. (1998) Trends Cell Biol. 8, 447-453
19. Iwatsubo, T., Odaka, A., Suzuki, N., Mizusawa, H., Nukina, N., and Ihara, Y. (1994) Neuron 13, 45-53
20. Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Chcler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P., and Relkin, N. R. (2000) Am. J. Pathol. 156, 15-20
21. Mochizuki, A., Tamaoka, A., Shimohata, A., Komatsuzaki, Y., and Shoji, S. (2000) Lancet 355, 42-43
22. D'Andrea, M. R., Nagele, R. G., Wang, H. Y., and Lee, D. H. (2002) Neurosci. Lett. 333, 163-166
23. Wirths, O., Multhaup, G., Czech, C., Blanchard, V., Moussaoui, S., Tremp, G., Pradier, L., Beyreuther, K., and Bayer, T. A. (2001) Neurosci. Lett. 306, 116-120
24. Chui, D. H., Tanahashi, H., Ozawa, K., Ikeda, S., Checler, F., Ueda, O., Suzuki, H., Araki, W., Inoue, H., Shirotani, K., Takahashi, K., Gallyas, F., and Tabira, T. (1999) Nat. Med. 5, 560-564
25. Fuller, S. J., Storey, E., Li, Q. M., Smith, A. I., Beyreuther, K., and Masters, C. L. (1995) Biochemistry 34, 8091-8098
26. Martin, B. L., Schrader-Fischer, C., Busciglio, J., Duke, M., Paganetti, P., and Yankner, B. A. (1995) J. Biol. Chem. 270, 26727-26730
27. Cook, D. G., Forman, M. S., Sung, J. C., Leight, S., Kolson, D. L., Iwatsubo, T., Lee, V. M., and Doms, R. W. (1997) Nat. Med. 3, 1021-1023
28. Hartmann, T., Bieger, S. C., Brühl, B., Tienari, P. J., Ida, N., Allsop, D., Roberts, G. W., Masters, C. L., Dotti, C. G., Unsicker, K., and Beyreuther, K. (1997) Nat. Med. 3, 1016-1020
29. Wild-Bode, C., Yamazaki, T., Capell, A., Leimer, U., Steiner, H., Ihara, Y., and Haass, C. (1997) J. Biol. Chem. 272, 16085-16088
30. Maltese, W. A., Wilson, S., Tan, Y., Suomensaari, S., Sinha, S., Barbour, R., and Mc Conlogue, L. (2001) J. Biol. Chem. 276, 20267-20279
31. Skovronsky, D. M., Doms, R. W., and Lee, V. M. (1998) J. Cell Biol. 141, 1031-1039
32. Sudoh, S., Hua, G., Kawamura, Y., Maruyama, K., Komano, H., and Yanagisawa, K. (2000) Eur, J. Biochem. 267, 2036-2045
33. Petanceska, S. S., Seeger, M., Checler, F., and Gandy, S. (2000) J. Neurochem. 74, 1878-1884
34. Iwata, H., Tomita, T., Maruyama, K., and Iwatsubo, T. (2001) J. Biol. Chem. 276, 21678-21685
35. Wilson, C. A., Doms, R. W., Zheng, H., and Lee, V. M. (2002) Nat. Neurosci. 5, 849-855
36. Lichtenthaler, S. F., Multhaup, G., Masters, C. L., and Beyreuther, K. (1999) FEBS Lett. 453, 288-292
37. Suzuki, N., Cheung, T. T., Cai, X. D., Odaka, A., Otvos, L. Jr., Eckman, C., Golde, T. E., and Younkin, S. G. (1994) Science 264, 1336-1340
38. Lichtenthaler, S. F., Wang, R., Grimm, H., Uljon, S. N., Masters, C. L., and Beyreuther, K. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3053-3058
39. Lichtenthaler, S. F., Ida, N., Multhaup, G., Masters, C. L., and Beyreuther, K. (1997) Biochemistry 36, 15396-15403
40. Peraus, G., Masters, C. L., and Beyreuther, K. (1997) J. Neurosci. 17, 7714-7724
41. Culvenor, J. G., Evin, G., Cooney, M. A., Wardan, H., Sharples, R. A., Maher, F., Reed, G., Diehlmann, A., Weidemann, A., Beyreuther, K., and Masters, C. L. (2000) Exp. Cell Res. 255, 192-206
42. Ida, N., Hartmann, T., Pantel, J., Schroeder, J., Zerfass, R., Foerstl, H., Sandbrink, R., Masters, C. L., and Beyreuther, K. (1996) J. Biol. Chem. 271, 22908-22914
43. Beher, D., Wrigley, J. D., Nadin, A., Evin, G., Masters, C. L., Harrison, T., Castrol, J. L., and Shearman, M. S. (2001) J. Biol. Chem. 276, 45394-45402
44. Hilbich, C., Monning, U., Grund, C., Masters, C. L., and Beyreuther, K. (1993) J. Biol. Chem. 268, 26571-26577
45. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
46. Mereken, M., Takahashi, H., Honda, T., Sato, K., Maruyama, M., Nakazato, Y., Noguchi, K., Imahori, K., and Takashima, A. (1996) FEBS Lett. 389, 297-303
47. Zhang, L., Song, L., Terracina, G., Liu, Y., Prnamanik, B., and Parker, E. (2001) Biochemistry 40, 5049-5055
48. Duff, K., Eckman, C., Zehr, C., Yu, X., Prada, C. M., Pereztur, J., Hutton, M., Buee, L., Harigaya, Y., Yager, D., Morgan, D., Gordon, M. N., Holcomb, L., Refolo, L., Zenk, B., Hardy, J., and Younkin, S. (1996) Nature 383, 710-713
49. Lemere, C. A., Lopera, F., Kosik, K. S., Lendon, C. L., Ossa, J., Saido, T. C., Yamaguchi, H., Ruiz, A., Martinez, A., Madrigal, L., Nincapie, L., Arango, J. C., Anthony, D. C., Koo, E. H., Goate, A. M., Selkoe, D. J., and Arango, J. C. (1996) Nat. Med. 2, 1146-1150
50. Tomita, T., Maruyama, K., Saido, T. C., Kume, H., Shinozaki, K., Tokuhiro, S., Capell, A., Walter, J., Grunberg, J., Haass, C., Iwatsubo, T., and Obata, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 2025-2030
51. Koo, E. H., and Squazzo, S. L. (1994) J. Biol. Chem. 269, 17386-17389
52. Tienari, P. J., Ida, N., Ikonen, E., Simons, M., Weidemann, A., Multhaup, G., Masters, C. L., Dotti, C. G., and Beyreuther, K. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 4125-4130
53. Perez, R. G., Soriano, S., Hayes, J. D., Ostaszewski, B., Xia, W., Selkoe, D. J., Chen, X., Stokin, G. B., and Koo, E. H. (1999) J. Biol. Chem. 274, 18851-18856
54. Turner, R. S., Suzuki, N., Chyung, A. S., Younkin, S. G., and Lee, V. M. (1996) J. Biol. Chem. 271, 8966-8970
55. Forman, M. S., Cook, D. G., Leight, S., Doms, R. W., and Lee, V. M. (1997) J. Biol. Chem. 272, 32247-32253
56. Murrell, J., Farlow, M., Ghetti, B., and Benson, M. D. (1991) Science 254, 97-99
57. Jackson, M. R., Nilsson, T., and Peterson, P. A. (1990) EMBO J. 9, 3153-3162
58. Andersson, H., Kappeler, F., and Hauri, H. P. (1999) J. Biol. Chem. 274, 15080-15084
59. Doms, R. W., Russ, G., and Yewdell, J. W. (1989) J. Cell Biol. 109, 61-72
60. Lippincott-Schwartz, J., Yuan, L. C., Bonifacino, J. S., and Klausner, R. D. (1989) Cell 56, 801-813
61. Wolfe, M. S., Xia, W., Ostaszewski, B. L., Diehl, T. S., Kimberlez, W. T., and Selkoe, D. J. (1999) Nature 398, 513-517
62. Tartakoff, A. M. (1983) Cell 32, 1026-1028
63. Mollenhauer, H. H., Morre, D. J., and Rowe, L. D. (1990) Biochim. Biophys. Acta 103, 225-246
64. Bos, K., Wraight, C., and Stanley, K. K. (1993) EMBO J. 12, 2219-2228
65. Ponnambalam, S., Rabouille, C., Luzio, J. P., Nilsson, T., and Warren, G. (1994) J. Cell Biol. 125, 253-268
66. Le, A., Steiner, J. L., Ferrell, G. A., Shaker, J. C., and Sifers, R. N. (1994) J. Biol. Chem. 269, 7514-7519
67. Allan, V. J., and Kreis, T. E. (1986) J. Cell Biol. 103, 2229-2239
68. Serafini, T., Stenbeck, G., Brecht, A., Lottspeich, F., Orci, L., Rothman, J. E., and Wieland, F. T. (1991) Nature 349, 215-220
69. Watson, R. T., and Pessin, J. E. (2000) J. Biol. Chem. 275, 1261-1268
70. Sambamurti, K., Shioi, J., Anderson, J. P., Pappolla, M. A., and Robakis, N. K. (1992) J. Neurosci. Res. 33, 319-329
71. Sisodia, S. S. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 6075-6079
72. De Strooper, B., Umans, L., Van Leuven, F., and Van Den Berghe, H. (1993) J. Cell Biol. 121, 295-304
73. Gouras, G. K., Xu, H., Jovanovic, J. N., Buxbaum, J. D., Wang, R., Greengard, P., Relkin, N. R., and Gandy, S. (1998) J. Neurochem. 71, 1920-1925
74. Tomita, S., Kirino, Y., and Suzuki, T. (1998) J. Biol. Chem. 273, 6277-6284
75. Lichtenthaler, S. F., Beher, D., Grimm, H. S., Wang, R., Shearman, M. S., Masters, C. L., and Beyreuther, K. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 1365-1370
76. Grziwa, B., Grimm, M. O., Masters, C. L., Beyreuther, K., Hartmann, T., and Lichtenthaler, S. F. (2003) J. Biol. Chem. 278, 6803-6808
77. Steiner, H., Winkler, E., Edbauer, D., Prokop, S., Basset, G., Yamasaki, A., Kostka, M., and Haass, C. (2002) J. Biol. Chem. 277, 39062-39065
78. Lee, S. F., Shah, S., Li, H., Yu, C., Han, W., and Yu, G. (2002) J. Biol. Chem. 277, 45013-45019
79. Kienlen-Campard, P., Miolet, S., Tasiaux, B., and Octave, J. N. (2002) J. Biol. Chem. 277, 15666-15670
80. Zhang, Y., Mc Laughlin, R., Goodyer, C., and LeBlanc, A. (2002) J. Cell Biol. 156, 519-529
81. Chyung, A. S., Greenberg, B. D., Cook, D. G., Doms, R. W., and Lee, V. M. (1997) J. Cell Biol. 138, 671-680
82. Wertkin, A. M., Turner, R. S., Pleasure, S. J., Golde, T. E., Younkin, S. G., Trojanowski, J. Q., and Lee, V. M. (1993) Proc. Natl. Acad. Sci. U. S. A. 90, 9513-9517
83. May, P., Reddy, Y. K., and Herz, J. (2002) J. Biol. Chem. 277, 18736-18743
84. Xu, H., Sweeney, D., Wang, R., Thinakaran, G., Lo, A. C., Sisodia, S. S., Greengard, P., and Gandy, S. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 3748-3752
85. Xia, W., Ray, W. J., Ostaszewski, B. L., Rahmati, T., Kimberley, W. T., Wolfe, M. S., Zhang, J., Goate, A. M., and Selkoe, D. J. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 9299-9304
86. Yang, D.-S., Tandon, A., Chen, F., Yu, G., Yu, H., Arawaka, S., Hasegawa, H., Duthie, M., Schmidt, S. D., Ramabhadran, T. V., Nixon, R. A., Mathews, P. M., Gandy, S. E., Mount, H. T. J., St George-Hyslop, P., and Fraser, P. E. (2002) J. Biol. Chem. 277, 28135-28142