Apoptotic activities of wild-type and Alzheimer's disease-related mutant presenilins in Drosophila melanogaster

Journal of Cell Biology

Volumn 146, Issue 6, 1999, Pages 1351-1364

  Ye, Yihong ^a   Fortini, Mark E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Alzheimer's disease; Apoptosis; Neurodegeneration; Notch signaling; Presenilin

Indexed keywords

PRESENILIN 1; PRESENILIN 2;

ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CARBOXY TERMINAL SEQUENCE; DROSOPHILA MELANOGASTER; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE LOSS; GENE MUTATION; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS;

ALLELES; ALZHEIMER DISEASE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; APOPTOSIS; CELL LINE; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EYE; GENE DOSAGE; GENE EXPRESSION; GENES, DOMINANT; INHIBITOR OF APOPTOSIS PROTEINS; INSECT PROTEINS; MEMBRANE PROTEINS; MODELS, GENETIC; MUTATION; PEPTIDE FRAGMENTS; PRESENILINS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SUPPRESSION, GENETIC; VIRAL PROTEINS; WING;

ANIMALIA; ARACHNIDA; DROSOPHILA MELANOGASTER; HEXAPODA; MELANOGASTER;

EID: 0033588991     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.146.6.1351     Document Type: Article

References (58)

1. Abrams, J.M., K. White, L.I. Fessler, and H. Steller. 1993. Programmed cell death during Drosophila embryogenesis. Development. 117:29-43.
2. Barinaga, M. 1998. Is apoptosis key in Alzheimer's disease? Science. 281:1303-1304.
3. Bonini, N.M., and M.E. Fortini. 1999. Surviving Drosophila eye development: integrating cell death with differentiation during formation of a neural structure. BioEssays. In press.
4. Brand, A.H., and N. Perrimon. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development. 118: 401-415.
5. Bursztajn, S., R. DeSouza, D.L. McPhie, S.A. Berman, J. Shioi, N.K. Robakis, and R.L. Neve. 1998. Overexpression in neurons of human presenilin-1 or a presenilin-1 familial Alzheimer disease mutant does not enhance apoptosis. J. Neurosci. 18:9790-9799.
6. Cagan, R.L., and D.F. Ready. 1989. Notch is required for successive cell decisions in the developing Drosophila retina. Genes Dev. 3:1099-1112.
7. Campion, D., A. Brice, C. Dumanchin, M. Puel, M. Baulac, V. De La Sayette, D. Hannequin, C. Duyckaerts, A. Michon, C. Martin, et al. 1996. A novel presenilin 1 mutation resulting in familial Alzheimer's disease with an onset age of 29 years. Neuroreport. 7:1582-1584.
8. Davidson, F.F., and H. Steller. 1998. Blocking apoptosis prevents blindness in Drosophila retinal degeneration mutants. Nature. 391:587-591.
9. Davis, J.A., S. Naruse, H. Chen, C. Eckman, S. Younkin, D.L. Price, D.R. Borchelt, S.S. Sisodia, and P.C. Wong. 1998. An Alzheimer's disease-linked PS1 variant rescues the developmental abnormalities of PS1-deficient embryos. Neuron. 20:603-609.
10. De Strooper, B., W. Annaert, P. Cupers, P. Saftig, K. Craessaerts, J.S. Mumm, E.H. Schroeter, V. Schrijvers, M.S. Wolfe, W.J. Ray, et al. 1999. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature. 398:518-522.
11. Deng, G., C.J. Pike, and C.W. Cotman. 1996. Alzheimer-associated presenilin-2 confers increased sensitivity to apoptosis in PC12 cells. FEBS Lett. 397:50-54.
12. Ellis, M.C., E.M. O'Neill, and G.M. Rubin. 1993. Expression of Drosophila glass protein and evidence for negative regulation of its activity in non-neuronal cells by another DNA-binding protein. Development. 119:855-865.
13. Fehon, R.G., P.J. Kooh, I. Rebay, C.L. Regan, T. Xu, M.A.T. Muskavitch, and S. Artavanis-Tsakonas. 1990. Molecular interactions between the protein products of the neurogenic loci Notch and Delta, two EGF-homologous genes in Drosophila. Cell. 61:523-534.
14. Fortini, M.E., I. Rebay, L.A. Caron, and S. Artavanis-Tsakonas. 1993. An activated Notch receptor blocks cell-fate commitment in the developing Drosophila eye. Nature. 365:555-557.
15. Gavrieli, Y., Y. Sherman, and S.A. Ben-Sasson. 1992. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J. Cell Biol. 119:493-501.
16. Guo, Q., K. Furukawa, B.L. Sopher, D.G. Pham, J. Xie, N. Robinson, G.M. Martin, and M.P. Mattson. 1996. Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid β-peptide. Neuroreport. 8:379-383.
17. Guo, Q., B.L. Sopher, D.G. Pham, K. Furukawa, N. Robinson, G.M. Martin, and M.P. Mattson. 1997. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid β-peptide: involvement of calcium and oxyradicals. J. Neurosci. 17:4212-4222.
18. Haass, C. 1997. Presenilins: genes for life and death. Neuron. 18:687-690.
19. Haass, C., and D.J. Selkoe. 1993. Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide. Cell. 75:1039-1042.
20. Hay, B.A., D.A. Wassarman, and G.M. Rubin. 1995. Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell death. Cell. 83:1253-1262.
21. Hong, C.-S., L. Caromille, Y. Nomata, H. Mori, D.E. Bredesen, and E.H. Koo. 1999. Contrasting role of presenilin-1 and presenilin-2 in neuronal differentiation in vitro. J. Neurosci. 19:637-643.
22. Jacobson, M.D., M. Weil, and M.C. Raff. 1997. Programmed cell death in animal development. Cell. 88:347-354.
23. Janicki, S., and M.J. Monteiro. 1997. Increased apoptosis arising from increased expression of the Alzheimer's disease-associated presenilin-2 mutation (N141I). J. Cell Biol. 139:485-495.
24. Jehn, B.M., W. Bielke, W.S. Pear, and B.A. Osborne. 1999. Protective effects of Notch-1 on TCR-induced apoptosis. J. Immunol. 162:635-638.
25. Kim, J., A. Sebring, J.J. Esch, M.E. Kraus, K. Vorwerk, J. Magee, and S.B. Carroll. 1996. Integration of positional signals and regulation of wing formation and identity by Drosophila vestigial gene. Nature. 382:133-138.
26. Levitan, D., and I. Greenwald. 1995. Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature. 377:351-354.
27. Levitan, D., and I. Greenwald. 1998. Effects of SEL-12 presenilin on LIN-12 localization and function in Caenorhabditis elegans. Development. 125:3599-3606.
28. Levitan, D., T.G. Doyle, D. Brousseau, M.K. Lee, G. Thinakaran, H.H. Slunt, S.S. Sisodia, and I. Greenwald. 1996. Assessment of normal and mutant human presenilin function in Caenorhabditis elegans. Proc. Natl. Acad. Sci. USA. 93:14940-14944.
29. Li, X., and I. Greenwald. 1997. HOP-1, a Caenorhabditis elegans presenilin, appears to be functionally redundant with SEL-12 presenilin and to facilitate LIN-12 and GLP-1 signaling. Proc. Natl. Acad. Sci. USA. 94:12204-12209.
30. Lindsley, D.L., and G.G. Zimm. 1992. The Genome of Drosophila melanogaster. Academic Press, San Diego, California.
31. McCall, K., and H. Steller. 1997. Facing death in the fly: genetic analysis of apoptosis in Drosophila. Trends Genet. 13:222-226.
32. Price, D.L., S.S. Sisodia, and D.R. Borchelt. 1998. Genetic neurodegenerative diseases: the human illness and transgenic models. Science. 282:1079-1083.
33. Qian, S., P. Jiang, X.-M. Guan, G. Singh, M.E. Trumbauer, H. Yu, H.Y. Chen, L.H.T. Van der Ploeg, and H. Zheng. 1998. Mutant human presenilin 1 protects presenilin 1 null mouse against embryonic lethality and elevates Aβ1-42/43 expression. Neuron. 20:611-617.
34. Raff, M. 1998. Cell suicide for beginners. Nature. 396:119-122.
35. Ready, D.F., T.E. Hanson, and S. Benzer. 1976. Development of the Drosophila retina, a neurocrystalline lattice. Dev. Biol. 53:217-240.
36. Robinow, S., and K. White. 1991. Characterization and spatial distribution of the ELAV protein during Drosophila melanogaster development. J. Neurobiol. 22:443-461.
37. Rulifson, E.J., and S.S. Blair. 1995. Notch regulates wingless expression and is not required for reception of the paracrine wingless signal during wing margin neurogenesis in Drosophila. Development. 121:2813-2824.
38. Seeger, M., C. Nordstedt, S. Petanceska, D.M. Kovacs, G.K. Gouras, S. Hahne, P. Fraser, L. Levesque, A.J. Czernik, P.S. George-Hyslop, et al. 1997. Evidence for phosphorylation and oligomeric assembly of presenilin 1. Proc. Natl. Acad. Sci. USA. 94:5090-5094.
39. Selkoe, D.J. 1998. The cell biology of β-amyloid precursor protein and presenilin in Alzheimer's disease. Trends Cell Biol. 8:447-453.
40. Shen, J., R.T. Bronson, D.F. Chen, W. Xia, D.J. Selkoe, and S. Tonegawa. 1997. Skeletal and CNS defects in Presenilin-1-deficient mice. Cell. 89:629-639.
41. Spradling, A.C., and G.M. Rubin. 1982. Transposition of cloned P elements into Drosophila germ line chromosomes. Science. 218:341-347.
42. Spreij, T.E. 1971. Cell death during the development of the imaginai discs of Calliphora erythrocephala. Netherlands J. Zool. 21:221-264.
43. Struhl, G., and A. Adachi. 1998. Nuclear access and action of Notch in vivo. Cell. 93:649-660.
44. Struhl, G., and I. Greenwald. 1999. Presenilin is required for activity and nuclear access of Notch in Drosophila. Nature. 398:522-525.
45. Struhl, G., K. Fitzgerald, and I. Greenwald. 1993. Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell. 74:331-345.
46. Tomlinson, A., and D.F. Ready. 1987. Cell fate in the Drosophila ommatidium. Dev. Biol. 123:264-275.
47. Tomlinson, A., D.D.L. Bowtell, E. Hafen, and G.M. Rubin. 1987. Localization of the sevenless protein, a putative receptor for positional information, in the eye imaginai disc of Drosophila. Cell. 51:143-150.
48. Van Doren, M., P.A. Powell, D. Pasternak, A. Singson, and J.W. Posakony. 1992. Spatial regulation of proneural gene activity: auto- and cross-activation of achaete is antagonized by extramacrochaetae. Genes Dev. 6:2592-2605.
49. Vézina, J., C. Tschopp, E. Andersen, and K. Müller. 1999. Overexpression of a C-terminal fragment of presenilin 1 delays anti-Fas induced apoptosis in Jurkat cells. Neurosci. Lett. 263:65-68.
50. 2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science. 271: 521-525.
51. Vito, P., T. Ghayur, and L. D'Adamio. 1997. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. J. Biol. Chem. 272:28315-28320.
52. Weihl, C.C., G.D. Ghadge, S.G. Kennedy, N. Hay, R.J. Miller, and R.P. Roos. 1999. Mutant presenilin-1 induces apoptosis and downregulates Akt/PKB. J. Neurosci. 19:5360-5369.
53. Wolff, T., and D.F. Ready. 1991. Cell death in normal and rough eye mutants of Drosophila. Development. 113:825-839.
54. Wolozin, B., K. Iwasaki, P. Vito, J.K. Ganjei, E. Lacanà, T. Sunderland, B. Zhao, J.W. Kusiak, W. Wasco, and L. D'Adamio. 1996. Participation of presenilin 2 in apoptosis: enhanced basal activity conferred by an Alzheimer mutation. Science. 274:1710-1713.
55. Wong, P.C., H. Zheng, H. Chen, M.W. Becher, D.J.S. Sirinathsinghji, M.E. Trumbauer, H.Y. Chen, D.L. Price, L.H.T. Van der Ploeg, and S.S. Sisodia. 1997. Presenilin 1 is required for Notch1 and Dll1 expression in the paraxial mesoderm. Nature. 387:288-292.
56. Ye, Y., and M.E. Fortini. 1998. Characterization of Drosophila presenilin and its colocalization with Notch during development. Mech. Dev. 79:199-211.
57. Ye, Y., N. Lukinova, and M.E. Fortini. 1999. Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants. Nature. 398:525-529.
58. Zhang, Z., H. Hartmann, V.M. Do, D. Abramowski, C. Sturchler-Pierrat, M. Staufenbiel, B. Sommer, M. van de Wetering, H. Clevers, P. Saftig, et al. 1998. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature. 395:698-702.