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Volumn 5, Issue 5, 1999, Pages 560-564

Transgenic mice with Alzheimer presenilin 1 mutations show accelerated neurodegeneration without amyloid plaque formation

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; PRESENILIN 1;

EID: 0032895651     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/8438     Document Type: Article
Times cited : (326)

References (29)
  • 1
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease
    • Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754-760 (1995).
    • (1995) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1
  • 2
    • 0031938304 scopus 로고    scopus 로고
    • Presenilin mutations in Alzheimer's disease
    • Cruts, M., Van Broeckhoven, C. Presenilin mutations in Alzheimer's disease. Hum. Mutat. 11, 183-190 (1998).
    • (1998) Hum. Mutat. , vol.11 , pp. 183-190
    • Cruts, M.1    Van Broeckhoven, C.2
  • 3
    • 0032544702 scopus 로고    scopus 로고
    • Familial Alzheimer's disease genes in Japanese
    • Kamimura, K. et al. Familial Alzheimer's disease genes in Japanese. J. Neural. Sci. 160, 76-81 (1998).
    • (1998) J. Neural. Sci. , vol.160 , pp. 76-81
    • Kamimura, K.1
  • 4
    • 16044373524 scopus 로고    scopus 로고
    • The amyloid β-protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
    • Scheuner, D. et al. The amyloid β-protein deposited in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nature Med. 2, 864-870 (1996).
    • (1996) Nature Med. , vol.2 , pp. 864-870
    • Scheuner, D.1
  • 5
    • 16044365171 scopus 로고    scopus 로고
    • The E280A presenilin-1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology
    • Lemere, C. A. et al. The E280A presenilin-1 Alzheimer mutation produces increased Aβ42 deposition and severe cerebellar pathology. Nature Med. 2, 1146-1150 (1996).
    • (1996) Nature Med. , vol.2 , pp. 1146-1150
    • Lemere, C.A.1
  • 6
    • 16044366039 scopus 로고    scopus 로고
    • Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1
    • Duff, K. et al. Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1. Nature 383, 710-713 (1996).
    • (1996) Nature , vol.383 , pp. 710-713
    • Duff, K.1
  • 7
    • 0030293676 scopus 로고    scopus 로고
    • Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo
    • Borchelt, D. R. et al. Familial Alzheimer's disease-linked presenilin 1 variants elevate Aβ1-42/1-40 ratio in vitro and in vivo. Neuron 17, 1005-1013 (1996).
    • (1996) Neuron , vol.17 , pp. 1005-1013
    • Borchelt, D.R.1
  • 8
    • 16944362157 scopus 로고    scopus 로고
    • Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice
    • Citron, M. et al. Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice. Nature Med. 3, 67-72 (1997).
    • (1997) Nature Med. , vol.3 , pp. 67-72
    • Citron, M.1
  • 9
    • 0030917601 scopus 로고    scopus 로고
    • Expression of mutant PS1 in PC12 cells increases their susceptibility to apoptosis by trophic factor withdrawal or by Aβ administration in vitro
    • Guo, Q. et al. Expression of mutant PS1 in PC12 cells increases their susceptibility to apoptosis by trophic factor withdrawal or by Aβ administration in vitro. J. Neurosci. 17, 4212-4222 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 4212-4222
    • Guo, Q.1
  • 10
    • 10544224542 scopus 로고    scopus 로고
    • Wolozin, B. et al. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710-1713 (1996).
    • (1996) Science , vol.274 , pp. 1710-1713
    • Wolozin, B.1
  • 11
    • 0027141379 scopus 로고
    • Four modified silver methods for thick sections of formaldehyde-fixed perikarya of all neurons, microglia cells and capillaries
    • Gallyas, F. et al. Four modified silver methods for thick sections of formaldehyde-fixed perikarya of all neurons, microglia cells and capillaries. J. Neurosci. Methods 50, 159-164 (1993).
    • (1993) J. Neurosci. Methods , vol.50 , pp. 159-164
    • Gallyas, F.1
  • 12
    • 0026547911 scopus 로고
    • Formation of "dark" (argyrophilic) neurons of various origin proceeds with a common mechanism of biophysical nature (a novel hypothesis)
    • Gallyas, F. et al. Formation of "dark" (argyrophilic) neurons of various origin proceeds with a common mechanism of biophysical nature (a novel hypothesis). Acta Neuropathol. 83, 504-509 (1992).
    • (1992) Acta Neuropathol. , vol.83 , pp. 504-509
    • Gallyas, F.1
  • 13
    • 0031052381 scopus 로고    scopus 로고
    • Amyloid, the presenilins and Alzheimer's disease
    • Hardy, J. Amyloid, the presenilins and Alzheimer's disease. Trends Neurosci. 20, 154-159 (1997).
    • (1997) Trends Neurosci. , vol.20 , pp. 154-159
    • Hardy, J.1
  • 14
    • 0006325405 scopus 로고    scopus 로고
    • Alzheimer's disease: A re-examination of the amyloid hypothesis
    • Neve, R. L., Robakis, N. K. Alzheimer's disease: a re-examination of the amyloid hypothesis. Trends Neurosci. 21, 15-19 (1998).
    • (1998) Trends Neurosci. , vol.21 , pp. 15-19
    • Neve, R.L.1    Robakis, N.K.2
  • 15
    • 0028985574 scopus 로고
    • Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523-527 (1995).
    • (1995) Nature , vol.373 , pp. 523-527
    • Games, D.1
  • 16
    • 0030612033 scopus 로고    scopus 로고
    • APPSw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1
    • Irizarry, M. C. et al. APPSw transgenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neurol. 56, 965-973 (1997).
    • (1997) J. Neuropathol. Exp. Neurol. , vol.56 , pp. 965-973
    • Irizarry, M.C.1
  • 17
    • 0030833055 scopus 로고    scopus 로고
    • Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin1 and amyloid precursor protein
    • Borchelt, D. R. et al. Accelerated amyloid deposition in the brains of transgenic mice coexpressing mutant presenilin1 and amyloid precursor protein. Neuron 19, 939-945 (1997).
    • (1997) Neuron , vol.19 , pp. 939-945
    • Borchelt, D.R.1
  • 18
    • 0031914718 scopus 로고    scopus 로고
    • Accelerated Alzheimer-type phenotype in trasgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgene
    • Holcomb, L. et al. Accelerated Alzheimer-type phenotype in trasgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgene. Nature Med. 4, 97-100 (1998).
    • (1998) Nature Med. , vol.4 , pp. 97-100
    • Holcomb, L.1
  • 19
    • 85056938105 scopus 로고    scopus 로고
    • Neuron loss in APP transgenic mice
    • Staufenbiel M. et al. Neuron loss in APP transgenic mice. Nature 395, 755-756 (1998).
    • (1998) Nature , vol.395 , pp. 755-756
    • Staufenbiel, M.1
  • 20
    • 0031596263 scopus 로고    scopus 로고
    • Proteolytic processing of Alzheimer's disease associated proteins
    • Haass C. et al. Proteolytic processing of Alzheimer's disease associated proteins. J. Neural Transm. Suppl. 53:159-167 (1998).
    • (1998) J. Neural Transm. Suppl. , vol.53 , pp. 159-167
    • Haass, C.1
  • 21
    • 0032531793 scopus 로고    scopus 로고
    • Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis
    • Zhang, Z. et al. Destabilization of β-catenin by mutations in presenilin-1 potentiates neuronal apoptosis. Nature 395, 698-702 (1998).
    • (1998) Nature , vol.395 , pp. 698-702
    • Zhang, Z.1
  • 22
    • 0031824782 scopus 로고    scopus 로고
    • Aging renders the brain vulnerable to amyloid β-protein neurotoxicity
    • Geula, C. et al. Aging renders the brain vulnerable to amyloid β-protein neurotoxicity. Nature Med. 4, 827-831 (1998).
    • (1998) Nature Med. , vol.4 , pp. 827-831
    • Geula, C.1
  • 23
    • 0031949628 scopus 로고    scopus 로고
    • A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1
    • Crook, R. et al. A variant of Alzheimer's disease with spastic paraparesis and unusual plaques due to deletion of exon 9 of presenilin 1. Nature Med. 4, 452-459 (1998).
    • (1998) Nature Med. , vol.4 , pp. 452-459
    • Crook, R.1
  • 24
    • 0026519550 scopus 로고
    • Stress induces neuronal death in the hippocampus of castrated rats
    • Mizoguchi, K. et al. Stress induces neuronal death in the hippocampus of castrated rats. Neurosci. Lett. 138, 157-160 (1992).
    • (1992) Neurosci. Lett. , vol.138 , pp. 157-160
    • Mizoguchi, K.1
  • 25
    • 0032127320 scopus 로고    scopus 로고
    • Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease
    • Chui, D.H. et al. Both N-terminal and C-terminal fragments of presenilin 1 colocalize with neurofibrillary tangles in neurons and dystrophic neurites of senile plaques in Alzheimer's disease. J. Neurosci. Res. 53, 99-106 (1998).
    • (1998) J. Neurosci. Res. , vol.53 , pp. 99-106
    • Chui, D.H.1
  • 26
    • 16944363478 scopus 로고    scopus 로고
    • Neuronal and glial apoptosis after traumatic spinal cord injury
    • Liu, X.Z. et al. Neuronal and glial apoptosis after traumatic spinal cord injury. J. Neurosci. 17, 5395-5406 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 5395-5406
    • Liu, X.Z.1
  • 27
    • 0028173384 scopus 로고
    • Immunohistochemical analyses of the leprosy brain show low β-amyloid but high abnormal tau deposition
    • Chui, D.H. et al. Immunohistochemical analyses of the leprosy brain show low β-amyloid but high abnormal tau deposition. Am. J. Pathol. 145, 771-775 (1994).
    • (1994) Am. J. Pathol. , vol.145 , pp. 771-775
    • Chui, D.H.1
  • 28
    • 14444267540 scopus 로고    scopus 로고
    • Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases
    • Barelli H. et al. Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy cases. Mol. Med. 3, 695-707 (1997).
    • (1997) Mol. Med. , vol.3 , pp. 695-707
    • Barelli, H.1
  • 29
    • 0023942398 scopus 로고
    • Immunohistochemical study of Alzheimer's disease using antibodies to synthetic amyloid and fibronectin
    • Koike, F. et al. Immunohistochemical study of Alzheimer's disease using antibodies to synthetic amyloid and fibronectin. J. Neurol. Sci. 85, 9-15 (1988).
    • (1988) J. Neurol. Sci. , vol.85 , pp. 9-15
    • Koike, F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.