Aβ42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domain

Journal of Biological Chemistry

Volumn 278, Issue 33, 2003, Pages 30748-30754

  Weggen, Sascha ^a   Eriksen, Jason L ^b   Sagi, Sarah A ^a   Pietrzik, Claus U ^a,c   Golde, Todd E ^b   Koo, Edward H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b MAYO CLINIC   (United States)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOCHEMISTRY; CELL MEMBRANES; DISEASE CONTROL; DRUG PRODUCTS; EPIDEMIOLOGY; PROTEINS;

ANTI-INFLAMMATORY DRUGS (AID);

ENZYME KINETICS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ENZYME INHIBITOR; ERB4 RECEPTOR PROTEIN; GAMMA SECRETASE; GAMMA SECRETASE INHIBITOR; IBUPROFEN; L 685458; MEMBRANE PROTEIN; NONSTEROID ANTIINFLAMMATORY AGENT; NOTCH RECEPTOR; SULINDAC SULFIDE; UNCLASSIFIED DRUG; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; CELL SURFACE RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 4; NOTCH1 PROTEIN, HUMAN; NOTCH1 RECEPTOR; PEPTIDE FRAGMENT; PROTEINASE; SECRETASE; TRANSCRIPTION FACTOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CELL CULTURE; CHO CELL; CONTROLLED STUDY; DRUG EFFECT; DRUG TARGETING; ENZYME INHIBITION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; REPORTER GENE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; GENETIC TRANSCRIPTION; GENETICS; HAMSTER; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE;

ANIMALIA;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPARTIC ENDOPEPTIDASES; CHO CELLS; CRICETINAE; ENDOPEPTIDASES; HUMANS; MEMBRANE PROTEINS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, NOTCH1; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0042904882     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304824200     Document Type: Article

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