A distinct ER/IC γ-secretase competes with the proteasome for cleavage of APP

Biochemistry

Volumn 39, Issue 4, 2000, Pages 810-817

  Skovronsky, Daniel M ^a   Pijak, Donald S ^a   Doms, Robert W ^a   Lee, Virginia M Y ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Center for Neurodegenerative Disease Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; CYCLOHEXIMIDE; ENZYME INHIBITOR; GAMMA SECRETASE; ISOENZYME; LACTACYSTIN; PEPTIDE FRAGMENT; PROTEASOME; PROTEASOME INHIBITOR;

ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN SYNTHESIS REGULATION; REACTION ANALYSIS;

ACETYLCYSTEINE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BINDING, COMPETITIVE; CELL COMPARTMENTATION; CHO CELLS; CRICETINAE; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; ENDOPEPTIDASES; ENDOPLASMIC RETICULUM; HUMANS; HYDROLYSIS; INTRACELLULAR FLUID; LEUPEPTINS; MULTIENZYME COMPLEXES; NEURONS; PEPTIDE FRAGMENTS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

ANIMALIA;

EID: 0034142022     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991728z     Document Type: Article

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