Zinc coordination sphere in biochemical zinc sites

BioMetals

Volumn 14, Issue 3-4, 2001, Pages 271-313

  Auld, David S ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Crystal structure; Metalloenzyme; NMR; Protein sequence; X ray crystallography; XAFS or X ray absorption fine structure

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; ALCOHOL DEHYDROGENASE; AMINO ACID TRANSFER RNA LIGASE; AMINOPEPTIDASE; ASPARTIC ACID; ASTACIN; BETA LACTAMASE; CARBONATE DEHYDRATASE; CARBOXYPEPTIDASE; CYSTEINE; GLUTAMIC ACID; HISTIDINE; MATRIX METALLOPROTEINASE; METALLOPROTEIN; NITRIC OXIDE SYNTHASE; NITROGEN; PHOSPHATASE; PHOSPHOTRIESTERASE; PROTEIN KINASE; SULFUR; SUPERANTIGEN; SUPEROXIDE DISMUTASE; THERMOLYSIN; UNCLASSIFIED DRUG; WATER; ZINC; ZINC PROTEIN;

AMINO ACID SEQUENCE; BINDING SITE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HUMAN; LIGAND BINDING; METABOLISM; NONHUMAN; REVIEW; ZINC DEFICIENCY;

ANIMALS; BINDING SITES; ENZYMES; HUMANS; LIGANDS; MODELS, BIOLOGICAL; PROTEIN BINDING; ZINC;

EID: 0035690880     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012976615056     Document Type: Review

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91. Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate
92. The solution structure of the amino-terminal HHCC domain of HIV-2 integrase: A three-helix bundle stabilized by zinc
93. Refined solution structure of the dimeric N-terminal HHCC domain of HIV-2 integrase
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97. Three-dimensional structure of horse liver alcohol dehydrogenase at 2-4 Å resolution
98. Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolution
99. Refined structure of bovine carbonic anhydrase III at 2.0 Å resolution
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101. The Schiff base complex of yeast 5-aminolaevulinic acid dehydratase with laevulinic acid
102. X-ray structure of 5-aminolevulinic acid dehydratase from Escherichia coli complexed with the inhibitor levulinic acid at 2.0 Å resolution
103. X-ray structure of 5-aminolaevulinate dehydratase, a hybrid aldolase
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105. Crystal structure of the zinc-dependent beta-lactamase from Bacillus cereus at 1.9 Å resolution: Binuclear active site with features of a mononuclear enzyme
106. Structural evolution of an enzyme specificity. The structure of rat carboxypeptidase A2 at 1.9 Å resolution
107. Cation-promoted association of a regulatory and target protein is controlled by protein phosphorylation
108. Structural studies of the Escherichia coli signal transducing protein IIAGlc: Implications for target recognition
109. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
110. Cu,Zn superoxide dismutase structure from a microbial pathogen establishes a class with a conserved dimer interface
111. Methionyl-tRNA synthetase zinc binding domain. Three-dimensional structure and homology with rubredoxin and gag retroviral proteins
112. Mapping of the zinc binding domain of Escherichia coli methionyl-tRNA synthetase
113. Pseudomonas aeruginosa contains a novel type V porphobilinogen synthase with no required catalytic metal ions
114. Superantigens - Powerful modifiers of the immune system
115. Zinc regulates the function of two superantigens
116. Novel zinc-binding centre in thermoacidophilic archaeal ferredoxins
117. Rat submaxillary gland serine protease, tonin. Structure solution and refinement at 1.8 Å resolution
118. Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase
119. 2+ site of glyoxalase I
120. The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen
121. Significance of metal ions in galactose-1-phosphate uridylyltransferase: An essential: Structural zinc and a nonessential structural iron
122. Inducible nitric oxide synthase: Role of the N-terminal beta-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction
123. Evolution of DD-peptidases and betalactamases
124. The potential of farnesyltransferase inhibitors as cancer chemotherapeutics
125. Interactions of Streptomyces griseus aminopeptidase with methionine product analogue: A structural study at 1.53 Å resolution
126. Crystal structure of avian carboxypeptidase D domain II: A prototype for the regulatory metallocarboxypeptidase subfamily
127. The three-dimensional structure of the native ternary complex of bovine pancreatic procarboxypeptidase A with proproteinase E and chymotrypsinogen C
128. First structure of a snake venom metalloproteinase: A prototype for matrix metalloproteinases/collagenases
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131. Crystal structures of acutolysin Å, a three-disulfide hemorrhagic zinc metalloproteinase from the snake venom of Agkistrodon acutus
132. The NMR structure of the inhibited catalytic domain of human stromelysin-1
133. Structure of astacin with a transitionstate analogue inhibitor
134. Streptomyces griseus aminopeptidase: X-ray crystallographic structure at 1.75 Å resolution
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137. Crystal structure of mammalian purple acid phosphatase
138. Crystal structure of the delta' subunit of the clamp-loader complex of E. coli DNA polymerase III
139. Leukotriene A4 hydrolase: A zinc metalloenzyme
140. The crystal structure of staphylococcal enterotoxin H: Implications for binding properties to MHC class II and TcR molecules
141. A potential catalytic site revealed by the 1.7-Å crystal structure of the aminoterminal signalling domain of Sonic hedgehog
142. Crystal structure of Serratia protease, a zinc-dependent proteinase from Serratia sp. E-15, containing a beta-sheet coil motif at 2.0 Å resolution
143. The solution structure of ribosomal protein L36 front Thermus thermophilus reveals a zinc-ribbon-like fold
144. Determination of the structure of Escherichia coli glyoxalase I suggests a structural basis for differential metal activation
145. Zn(II) dependence of the Aeromonas hydrophila AE036 metallo-beta-lactamase activity and stability
146. Functional diversity, conservation, and convergence in the evolution of the alpha-, beta-, and gamma-carbonic anhydrase gene families
147. Variable zinc coordination in endostatin
148. Structural analysis of zinc substitutions in the active site of thermolysin
149. A model of the transition state in the alkaline phosphatase reaction
150. Solution structure of cysteine rich domain of rat protein kinase C
151. Crystal and molecular structures of native and CTPliganded aspartate carbamoyltransferase from Escherichia coli
152. Structure of the DNA repair enzyme endonuclease IV and its DNA complex: Double-nucleotide flipping at abasic sites and three-metal-ion catalysis
153. High-resolution (1.5 Å) crystal structure of phospholipase C from Baccillus cereus
154. 2+-farnesyltransferase indicates metal coordination of the substrate thiolate
155. Crystal structure of carbonic anhydrase from Neisseria gonorrhoeae and its complex with the inhibitor acetazolamide
156. Identification and characterization of zinc binding sites in protein kinase C
157. Metal binding specificity in carbonic anhydrase is influenced by conserved hydrophobic core res dues
158. Taxonomy and function of Cl protein kinase C homology domains
159. Structure of human beta I beta I alcohol dehydrogenase: Catalytic effects of non-active-site substitutions
160. Structures of three human beta alcohol dehydrogenase variants. Correlations with their functional differences
161. A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL
162. Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: Molecular explanations for X-linked agammaglobulinaemia
163. Solution structure of cysteine-rich domain of protein kinase C alpha
164. A closer look at the active site of gamma-class carbonic anhydrases: High-resolution crystallographic studies of the carbonic anhydrase from Methanosarcina thermophila
165. Novel zinc-containing ferredoxin family in thermoacidophilic archaea
166. The porphobilinogen synthase family of metalloenzymes
167. Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis
168. Nomenclature of alcohol dehydrogenases
169. Mammalian alcohol dehydrogenases of separate classes: Intermediates between different enzymes and intraclass isozymes
170. Crystal structure of human erythrocyte carbonic anhydrase B. Three-dimensional structure at a nominal 2.2-Å, resolution
171. Extended metal environments of cytochrome c oxidase structures
172. Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E
173. The crystal structure of human interferon beta at 2.2-Å resolution
174. Reaction mechanism of alkaline phosphatase based on crystal structures. Two-metal ion catalysis
175. Structure and mechanism of bovine lens leucine aminopeptidase
176. The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases
177. A lefthand beta-helix revealed by the crystal structure or a carbonic anhydrase from the archaeon Methanosarcina thermophila
178. Crystal structures of human calcineurin and the human FKBP12-FKS06-calcineurin complex
179. Three-dimensional structure of Cu,Zn-superoxide dismutase from spinach at 2.0 Å resolution
180. The dimetal centre in purple acid phosphatases
181. Mechanism of Fe(III)-Zn(II) purple acid phosphatase based on crystal structures
182. Probes of mechanism and transition-state structure in the alcohol dehydrogenase reaction
183. Zinc finger peptides for the regulation of gene expression
184. X-ray structure of the Escherichia coli periplasmic 5'-nucleotidase containing a dimetal catalytic site
185. The crystal structure of the DNase domain of colicin E7 in complex with its inhibitor Im7 protein
186. NADP-dependent bacterial alcohol dehydrogenases: Crystal structure, cofactor-binding and cofactor specificity of the ADHs of Clostridium beijerinckii and Thermoanaerobacter brockii
187. The structure of rhamnose isomerase from Escherichia coil and its relation with xylose isomerase illustrates a change between inter and intrasubunit complementation during evolution
188. Crystal structure of H2-proteinase from the venom of Trimeresurus flavoviridis
189. Structure of the zinc endoprotease from Streptomyces caespitosus
190. Sequence homology and structural analysis of the clostridial neurotoxins
191. Crystal structure of botulinum neurotoxin type A and implications for toxicity
192. Zinc finger proteins: New insights into structural and functional diversity
193. The crystal structure of pneumococcal surface antigen PsaA reveals a metal-binding site and a novel structure for a putative ABC-type binding protein
194. Control of coenzyme binding to horse liver alcohol dehydrogenase
195. Crystal structure of NAD(+)-dependent DNA ligase: Modular architecture and functional implications
196. Treponema pallidum TroA is a periplasmic zinc-binding protein with a helical backbone
197. Crystal structure of colicin E3 immunity protein: An inhibitor of a ribosome-inactivating RNase
198. Crystal structures of zinc-free and -bound heine domain of human inducible nitric-oxide synthase. Implications for dimer stability and comparison with endothelial nitric-oxide synthase
199. Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor
200. Structural consequences of the active site substitution Cys181 ⇒ Ser in metallo betalactamase from Bacteroides fragilis
201. Crystal structure of human carbonic anhydrase C
202. Instability and decay of the primary structure of DNA
203. Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 Å resolution with a mu-(hydr)oxo bridged di-iron center
204. Carbonic anhydrose and the role of orientation in catalysis
205. Recent advances in zinc enzymology
206. A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
207. Structure of human methionine aminopeptidase-2 complexed with fumagillin
208. The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site
209. Structure of the catalytic domain of fibroblast collagenase complexed with an inhibitor
210. Crystal structures of recombinant 19-kDa human fibroblast collagenase complexed to itself
211. Crystal structures of MMP-1 and -13 reveal the structural basis for selectivity of collagenase inhibitors
212. Insights into the mechanism of Escherichia coli methionine aminopeptidase from the structural analysis of reaction products and phosphorus-based transition-state analogues
213. Zinc fingers are sticking together
214. Zinc-bundle structure of the essential RNA polymerase subunit RPB10 from Methanobacterium thermoautotrophicum
215. Crystal structure of Sglutathiolated carbonic anhydrase III
216. Crystal structure of the ARF-GAP domain and ankyrin repeats of PYK2-associated protein beta
217. Cobalt(II-substituted class III alcohol and sorbitol dehydrogenases from human liver
218. Inhibitory sites in enzymes: Zinc removal and reactivation by thionein
219. Thiolate ligands in metallothionein confer redox activity on zinc clusters
220. Influence of anions and pH on the conformational change of horse liver alcohol dehydrogenase induced by binding of oxidized nicotinamide adenine dinucleotide: Binding of chloride to the catalytic metal ion
221. Interleukin 1 beta-converting enzyme related proteases/caspases are involved in TRAIL-induced apoptosis of myeloma and leukemia cells
222. Solution structure of the cysteine-rich domain of the Escherichia coli chaperone protein DnaJ
223. Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme
224. Structural basis of the action of thermolysin and related zinc proteases
225. The conformation of thermolysin
226. Crystal structure of Escherichia coli methionyl-tRNA synthetase highlights speciesspecific features
227. Leukotriene A4 hydrolase: Determination of the three zinc-binding ligands by site-directed mutagenesis and zinc analysis
228. On the enzymatic activation of NADH
229. A new subclass of the zinc metalloproteases superfamily revealed by the solution structure of peptide deformylase
230. X-ray structure of beta-carbonic anhydrase from the red alga, Porphyridium purpureum, reveals a novel catalytic site for CO(2) hydration
231. Crystal structure of the unliganded alkaline protease from Pseudomonos aeruginosa 1FO3080 and its conformational changes on ligand binding
232. Structure of human promatrix metalloproteinase-2: Activation mechanism revealed
233. The solution structure of the Raf-1 cysteine-rich domain: A novel fas and phospholipid binding site
234. NMR solution structure of the catalytic fragment of human fibroblast collagenase complexed with a sulfonamide derivative of a hydroxamic acid compound
235. High-resolution solution structure of the inhibitor-free catalytic fragment of hnman fibroblast collagenase determined by multidimensional NMR
236. Crystal structure and mutagenic analysis of the inhibtor-of-apoptosis protein survivin
237. Trapping and visualization of a covalent enzyme-phosphate intermediate
238. Metalcoordination sphere in the methylated Ada protein-DNA co-complex
239. Characterisation of the calcium-binding Cterminal domain of Clostridium perfringens alpha-toxin
240. Enzyme structure with two catalytic sites for double-sieve selection of substrate
241. Structure of human neutral endopeptidase (Neprilysin) complexed with phosphoramidon
242. Unusual trigonal-planar copper configuration revealed in the atomic structure of yeast copper-zinc superoxide dismutase
243. Structure of the zinc-binding domain of Bacillus stearothermophilus DNA primase
244. Superantigens as immunomodulators: Recent structural insights
245. Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site
246. Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors
247. Atomic structures of wild-type and thermostable mutant recombinant human Cu.Zn superoxide dismutase
248. Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution
249. 2+beta-lactamase. Role of the conserved cysteine in the catalytic mechanism
250. Mono- and binuclear Zn-beta-lactamase from Bacteroides fragilis: Catalytic and structural roles of the zinc ions
251. Crystal structure of neutral protease from Bacillus cereus refined at 3,0 Å resolution and comparison with the homologous but more thermostable enzyme thermolysin
252. Genetically engineered zinc-chelating adenylate kinase from Escherichia coli with enhanced thermal stability
253. Zinc chelation and structural stability of adenylate kinase from Bacillus subtilis
254. Functional and Crystallographic Characterization of Salmonella typhimurium Cu,Zn Superoxide Disnqutase Coded by the sodCI Virulence Gene
255. Unique structural features of the monomeric Cu,Zn superoxide dismutase from Escherichia coli. revealed by X-ray crystallography
256. The structure of the 2A proteinase from a common cold virus: A proteinase responsible for the shut-off of host-cell protein synthesis
257. In vitro study of the NS2-3 protease of hepatitis C virus
258. Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase
259. Structural insights into the protein splicing mechanism of PI-SceI
260. Refined structures of three crystal forms of toxic shock syndrome toxin-I and of a tetramutant with reduced activity
261. Identification and characterization of novel superantigens from Streptococcus pyogenes
262. The regulatory domain of protein kinase C coordinates four atoms of zinc
263. Carboxypeptidase A: A protein and an enzyme
264. X-ray structure of T4 endonuclease VII: A DNA junction resolvase with a novel fold and unusual domain-swapped dimer architecture
265. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography
266. Crystal structure of constitutive endothelial nitric oxide synthase: A paradigm for pterin function involving a novel metal center
267. Crystal structure of cod liver class I alcohol dehydrogenase: Substrate pocket and structurally variable segments
268. Immunochemical characterization of antigenic domains on human interferon-beta: Spatially distinct epitopes are associated with both antiviral and antiproliferative activities
269. Refined crystal structure of carboxypeptidase A at 1.54 Å resolution
270. Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2
271. 2+ ligand in the catalytic mechanism of human glyoxalase I
272. Metal-containing exopeptidases
273. Structure of the cobalt-dependent methionine aminopeptidase from Escherichia coil: A new type of proteolytic enzyme
274. Crystal structure of the streptococcal superantigen SPEC: Dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
275. Kinetic and structural characterization of spinach carbonic anhydrase
276. Crystal structure of carboxypeptidase G2, a bacterial enzyme with applications in cancer therapy
277. On the role of Glu-68 in alcohol dehydrogenase
278. Computational sequence analysis of matrix metalloproteinases
279. Zinc ion mediated amino acid discrimination by threonyl-tRNA synthetase
280. The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site
281. A structural and functional comparison of staphylococcal enterotoxins A and C2 reveals remarkable similarity and dissimilarity
282. Crystal structure of the superantigen staphylococcal enterotoxin type A
283. The crystal structure of the Leishmania major surface proteinase leishmanolysin (gp63)
284. Structure of carboxypeptidase B at 2-8 Å resolution
285. Octahedral metal coordination in the active site of glyoxalase I as evidenced by the properties of Co(II)-glyoxalase I
286. 2+
287. Probing the functional role of two conserved active site aspartates in mouse adenosine deaminase
288. The catalytic mechanism of carbonic anhydrase: Implications of a rate limiting protolysis of water
289. Insights into editing from an iletRNA synthetase structure with tRNAile and mupirocin
290. 2+
291. Prokaryotic carbonic anhydrases
292. Zinc content of promatrilysin, matrilysin and the stromelysin catalytic domain
293. Matrilysin: Expression, purification, and characterization
294. The X-ray structure of a growth hormone-prolactin receptor complex
295. Multiple modes of activation of latent human fibroblast collagenase: Evidence for the role of a Cys73 active-site zinc complex in latency and a 'cysteine switch' mechanism for activation
296. Redox signaling: Nitrosylation and related target interactions of nitric oxide
297. Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme-drug discrimination
298. Crystal structure of the secretory form of membraneassociated human carbonic anhydrase IV at 2.8-Å resolution
299. Kinetic and X-ray structural studies of three mutant E. coli alkaline phosphatases: Insights into the catalytic mechanism without the nucleophile Ser 102
300. A revised mechanism for the alkaline phosphatase reaction, involving three metal ions
301. Fluorescent oligopeptide substrates for kinetic characterization of the specificity of Astacus protease
302. Astacus protease, a zinc metalloenzyme
303. Crystal structure of a purple acid phosphatase containing a dinuclear Fe(III)-Zn(II) active site
304. Transition state analogue Lleucinephosphonic acid bound to bovine lens leucine aminopeptidase: X-ray structure at 1.65Å resolution in a new crystal form
305. Crystal structure of farnesyl protein transferase complexed with a CaaX peptide and farnesyl diphosphate analogue
306. Crystal structure of the 'cab type' beta class carbonic anhydrase from the archaeon Methanobacterium thermoautotrophicum
307. Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg). from an extreme thermophile. Thermus thermophilus HB8
308. The 2.0 Å crystal structure of Thermos thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules
309. 2+-mediated homodimerization
310. 2+ at 2.7 Å resolution. Implications for major histocompatibility complex class II binding
311. Crystal Structures of mouse class II alcohol dehydrogenase reveal determinants of substrate specificity and catalytic efficiency
312. Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B
313. High-resolution crystals of methionine aminopeptidase from Pyrococcus furiosus obtained by water-mediated transformation
314. Crystal structure of methionine aminopeptidase from hyperthermophile, Pyrococcus furiosus
315. Determination and analysis of the 2 Å-structure of copper, zinc superoxide dismutase
316. Aminopeptidases: Structure and function
317. Crystal structure of carboxypeptidase T from Thermoactinomyces vulgaris
318. Three-dimensional structure of the elastase of Pseudomonas aeruginosa at 1.5-Å resolution
319. Structural analysis of the H166G site-directed mutant of galactose-1-phosphate uridylyltransferase complexed with either UDP-glucose or UDP-galactose: Detailed description of the nucleotide sugar binding site
320. Crystal structure of human leukotriene A(4) hydrolase, a bifunctional enzyme in inflammation
321. Crystallographic and functional studies of very short patch repair endonuclease
322. The crystal structure of the Ll metallobeta-lactamase from Stenotrophomonas maltophilia at 1.7 Å resolution
323. Crystal structure of a mammalian purple acid phosphatase
324. The metal binding site of the hepatitis C virus NS3 protease. A spectroscopic investigation
325. 2O of zinc enzymes
326. Zinc coordination, function, and structure of zinc enzymes and other proteins
327. Active zinc binding sites of zinc metalloenzymes
328. Functional zinc-binding motifs in enzymes and DNA-binding proteins
329. New perspective on zinc biochemistry: Cocatalytic sites in multi-zinc enzymes
330. Zinc: Biological Functions and Coordination Motifs
331. Zinc fingers, zinc clusters, and zinc twists in DNA-binding protein domains
332. The biochemical basis of zinc physiology
333. The metallobiochemistry of zinc enzymes
334. Solution structure of the catalytic domain of human stromelysin with a hydrophobic inhibitor
335. Three-dimensional structure of the zinc-containing phosphotriesterase with the bound substrate analog diethyl 4methylbenzylphosphonate
336. Structure of the human anti-apoptotic protein survivin reveals a dimeric arrangement
337. Crystal structure of Penicillium citrinum P1 nuclease at 2.8 Å resolution
338. 2+ as a cofactor: A case of mistaken identity?
339. High-resolution structure of an archaeal zinc ribbon defines a general architectural motif in eukaryotic RNA polymerases
340. Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity
341. A metal-mediated hydride shift mechanism for xylose isomerase based on the 1.6 Å Streptomyces rubiginosus structures with xylitol and D-Xylose
342. A pre-transition-state mimic of an enzyme: X-ray structure of adenosine deaminase with bound 1-deazaadenosine and zinc-activated water
343. Atomic structure of adenosine deaminase complexed with a transition-state analog: Understanding catalysis and immunodeficiency mutations
344. Structure of the 30S ribosomal subunit
345. Transitionstate selectivity for a single hydroxyl group during catalysis by cytidine deaminase
346. X-ray structure of human class IV sigmasigma alcohol dehydrogenase. Structural basis for substrate specificity
347. Complex of NS3 protease and NS4A peptide of BK strain hepatitis C virus: A 2.2 Å resolution structure in a hexagonal crystal form
348. Kinetic properties and metal content of the metallo-beta-lactamase CcrA harboring selective amino acid substitutions
349. Structure of human chi chi alcohol dehydrogenase: A glutathione-dependent formaldehyde dehydrogenase
350. Crystal structure of a thermophilic cytochrome P450 from the archaeon sulfolobus solfataricus
351. Crystal structure of a eukaryote/archaeon-like prolyl-tRNA synthetase and its complex with tRNA(Pro)(CGG)
352. Protein prenylation: Molecular mechanisms and functional consequences
353. Crystal structure of Thermus aquaticus core RNA polymerase at 3.3 Å resolution
354. Crystal structure of the cys2 activator-binding domain of protein kinase C delta in complex with phorbol ester
355. Crystal structure of Rab geranylgeranyltransferase at 2.0 Å resolution
356. Structure of acutolysin-C, a haemorrhagic toxin from the venom of Agkistrodon acutus, providing further evidence for the mechanism of the pH-dependent proteolytic reaction of zinc metalloproteinases