Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: Molecular basis of isozyme-drug discrimination

Protein Science

Volumn 7, Issue 3, 1998, Pages 556-563

  Stams, Travis ^a   Chen, Yun ^a   Boriack Sjodin, P Ann ^a,d   Hurt, Jonathan D ^b   Liao, John ^c   May, Jesse A ^c   Dean, Tom ^c   Laipis, Philip ^b   Silverman, David N ^b   Christianson, David W ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^c ALCON RESEARCH LTD   (United States)

^d ROCKEFELLER UNIVERSITY   (United States)

Author keywords

Brinzolamide; Carbonic anhydrase; Crystallography

Indexed keywords

ANTIGLAUCOMA AGENT; BRINZOLAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IV; ISOENZYME; MEMBRANE ENZYME; PHOSPHATIDYLINOSITOL; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ARTICLE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DRUG PROTEIN BINDING; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME LOCALIZATION; GLAUCOMA; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION;

MURINAE;

EID: 0031887344     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560070303     Document Type: Article

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