Refined structures of three crystal forms of toxic shock syndrome toxin- 1 and of a tetramutant with reduced activity

Protein Science

Volumn 6, Issue 6, 1997, Pages 1220-1227

  Prasad, G Sridhar ^a,c   Radhakrishnan, Ramaswamy ^a,d   Mitchell, David T ^a   Earhart, Cathleen A ^a   Dinges, Martin M ^a   Cook, William J ^b   Schlievert, Patrick M ^a   Ohlendorf, Douglas H ^a,e  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^b University of Alabama at Birmingham   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^e UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Protein conformation; Staphylococcus aureus; Superantigens; Toxins; X ray crystallography

Indexed keywords

STAPHYLOCOCCUS TOXIN; SUPERANTIGEN;

ARTICLE; CRYSTAL STRUCTURE; MUCOCUTANEOUS LYMPH NODE SYNDROME; PRIORITY JOURNAL; PROTEIN CONFORMATION; STAPHYLOCOCCUS AUREUS; SUDDEN INFANT DEATH SYNDROME; TOXIC SHOCK SYNDROME; TOXIN STRUCTURE;

STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0030958816     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1002/pro.5560060610     Document Type: Article

References (58)

1. Abrahmsen L, Dohlsten M, Segren S, Bjork P, Jonsson E, Kalland T. 1995. Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J 14:2978-2986.
2. Acharya KR, Passalacqua EF, Jones EY, Harlos K, Stuart DI, Brehm RD, Tranter HS. 1994. Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1. Nature 367:94-97.
3. Barsumian EL, Schlievert PM, Watson DW. 1978. Nonspecific and specific immunological mitogenicity by group A streptococcal pyrogenic exotoxins. Infect Immun 22:681-688.
4. Betley MJ, Borst DW, Regassa LB. 1992. Staphylococcal enterotoxins, toxic shock syndrome toxin and streptococcal pyrogenic exotoxins: A comparative study of their molecular biology. Chem Immunol 55:1-35.
5. Blanco L, Choi EM, Connolly K, Thompson MR, Bonventre PF. 1990. Mutants of staphylococcal toxic shock syndrome toxin 1: Mitogenicity and recognition by a neutralizing monoclonal antibody. Infect Immun 58:3020-3028.
6. Blomster-Hautamaa DA, Schlievert PM. 1988. Preparation of toxic shock syndrome toxin-1. Meth Enzymol 165:37-43.
7. Bohach GA, Fast DJ, Nelson RD, Schlievert PM. 1990. Staphylococcal and streptococcal pyrogenic toxins involved in toxic shock syndrome and related illnesses. Crit Rev Microbiol 17:251-272.
8. Bonventre PF, Heeg H, Cullen C, Lian CJ. 1993. Toxicity of recombinant toxic shock syndrome toxin 1 and mutant toxins produced by Staphylococcus aureus in a rabbit infection model of toxic shock syndrome. Infect Immun 61:793-799.
9. Brünger AT. 1992. X-PLOR, Version 3.1: A System for X-ray Crystallography and NMR. New Haven, Connecticut: Yale University Press.
10. Cambillau C, Horjales E. 1987. TOM: A FRODO subpackage for protein-ligand fitting with interactive energy minimization. J Mol Graphics 5:175-177.
11. Cullen C, Heeg H, Blanco L, Bonventre P, Choi E. 1993. A mutation in TSST-1 which dissociates T cell stimulatory activity from MHC class II binding. J Immunol 150:153A.
12. Dao-pin S, Anderson DE, Baase WA, Dahlquist FW, Matthews BW. 1991. Structural and thermodynamic consequences of burying a charged residue with the hydrophobic core of T4 lysozyme. Biochemistry 30:11521-11529.
13. Deresiewicz RL, Woo JH, Chan M, Finberg RW, Kasper DL. 1994. Mutations affecting the activity of toxic shock syndrome toxin-1. Biochemistry 33: 12844-12851.
14. Driessen C, Hirv K, Kircherner H, Rink L. 1995. Zinc regulates cytokine induction by superantigens and lipopolysaccharide. Immunology 84:272-277.
15. Earhart CA, Prasad GS, Murray DL, Novick RP, Schlievert PM, Ohlendorf DH. 1993. Growth and analysis of crystal forms of toxic shock syndrome toxin 1. Proteins 17:329-334.
16. Edwin C, Kass EH. 1989. Identification of functional antigenic segments of toxic shock syndrome toxin 1 by differential immunoreactivity and by differential mitogenic responses of human peripheral blood mononuclear cells, using active toxin fragments. Infect Immun 57:2230-2236.
17. Fields BA, Malchiodi EL, Li H, Ysern X, Stauffacher CV, Schlievert PM, Karjalainen K, Mariuzza RA. 1996. Crystal structure of a T-cell receptor β chain complexed with a superantigen. Nature 182:1833-1845.
18. Eraser JD, Urban RG, Strominger JL, Robinson H. 1992. Zinc regulates the function of two superantigens. Proc Natl Acad Sci USA 89:5507-5511.
19. Ho G, Campbell WH, Carlson E. 1989. Ovine-associated Staphylococcus aureus protein with immunochemical similarity to toxic shock syndrome toxin 1. J Clin Microbiol 27:210-212.
20. Hoffmann ML, Jablonski LM, Crum KK, Hackett SP, Chi Y-I, Stauffacher CV, Stevens DL, Bohach GA. 1994. Predictions of T-cell receptor-and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1. Infect Immun 62:3396-3407.
21. Howard AJ, Gilliland GL, Finzel BC, Poulos TL, Ohlendorf DH, Salemme FR. 1987. Use of an imaging proportional counter in macromolecular crystallography. J Appl Cryst 20:383-387.
22. Hudson KR, Robinson H, Fraser JD. 1993. Two adjacent residues in staphylococcal enterotoxins A and E determine T cell receptor Vβ specificity. J Exp Med 177:175-184.
23. Hurley JM, Shimonkevitz R, Hanagan A, Enney K, Boen E, Kotzin BL, Matsumura M. 1995. Identification of class II MHC and T cell receptor binding sites in the superantigen toxic shock syndrome toxin-1. J Exp Med 181:2229-2235.
24. Hynes T, Fox RO. 1991. Engineering alternative beta-turn types in staphylococcal nuclease. Proteins 10:92-105.
25. Irwin MJ, Hudson KR, Fraser JD, Gascoigne NRJ. 1992. Enterotoxin residues determining T-cell receptor Vβ binding specificity. Nature 359:841-843.
26. Jones TA. 1978. A graphics model building and refinement system for macromolecules. J Appl Cryst 11:268-272.
27. Jones TA, Zou JY, Cowan SW, Kjeldgaard M. 1991. Improved methods for finding protein models in electron density maps and the location of error in these models. Acta Cryst A47:110-119.
28. Kappler JW, Herman, A, Clements J, Marrack P. 1992. Mutations defining functional regions of the superantigen staphylococcal enterotoxin B. J Exp Med 175:387-396.
29. Kim J, Urban RG, Strominger JL, Wiley DC. 1994. Crystallographic structure of toxic shock syndrome toxin-1 complexed with a human class II major histocompatibility molecule, HLA-DR1. Science 266:1870-1874.
30. Laskowski RA, MacArthur MW, Moss SD, Thornton JM. 1993. PROCHECK: A program to check the stereochemical quality of protein structures. J Appl Cryst 26:283-291.
31. Lee PK, Kreiswirth BN, Deringer JR, Projan SJ, Eisner W, Smith BL, Carlson E, Novick RN, Schlievert PM. 1992. Nucleotide sequences and biological properties of toxic shock syndrome toxin-1 from ovine and bovine-associated Staphylococcus aureus. J Infect Dis 165:1056-1063.
32. Leung DYM, Meissner HC, Fulton DR, Murray DL, Kotzin BL, Schlievert PM. 1993. Toxic shock syndrome toxin-secreting Staphylococcus aureus in Kawasaki syndrome. Lancet 342:1385-1388.
33. Merritt EA, Sarfaty S, van den Akken F, L'Hoir C, Martial JA, Hol WG. 1994. Crystal structure of cholera toxin β-pentamer bound to receptor GM1 pentasaccharide. Protein Sci 3:166-175.
34. Mitchell DT, Kim J, Urban RG, Strominger JL, Schlievert PM, Wiley DC, Ohlendorf DH. 1996. Comparison of structures of toxic shock syndrome toxin-1 unbound and bound to a class II major histocompalibility molecule. In: Leung DYM, Huber BT, Schlievert PM, eds. Superantigens: Structure, biology and relevance to human disease. New York: Marcel Dekker. pp 149-166.
35. Murray DL, Earhart CA, Mitchell DT, Ohlendorf DH, Novick RP, Schlievert PM. 1995. Localization of biologically important regions on toxic shock syndrome toxin-1. Infect Immun 64:371-374.
36. Murray DL, Prasad GS, Earhart CA, Leonard BAB, Kreiswirth BN, Novick RP, Ohlendorf DH, Schlievert PM. 1994. Immunological and biochemical properties of mutants of toxic shock syndrome toxin-1. J Immunol 152:87-95.
37. Murzin AG. 1993. OB(oligonucleotide/oligosaccharide binding)-fold: Common structural and functional solution for non-homologous sequences. EMBO J 12:861-867.
38. Ohlendorf DH. 1994. The accuracy of refined protein structures. II. Comparison of four independently refined models of human interleukin 1β. Acta Cryst D50:808-812.
39. Overington JP. 1992. Comparison of three-dimensional structures of homologous proteins. Curr Opin Struct Biol 2:394-401.
40. Newbould MJ, Malam J, McIllmurray JM, Morris JA, Telford DR, Barson AJ. 1989. Immunohistological localization of staphylococcal toxic shock syndrome (TSST-1) antigen in sudden infant death syndrome. J Clin Pathol 42:935-939.
41. Papageorgiou AC, Acharya KR, Shapiro R, Passalacqua R, Brehm RD, Tranter HS. 1995. Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site. Structure 3:769-779.
42. Papageorgiou AC, Brehm RD, Leonidas DD, Tranter HS, Acharya KR. 1996. The refined crystal structure of toxic shock syndrome toxin-1 at 2.07 Å resolution. J Mol Biol 260:553-569.
43. Pontzer CH, Irwin MJ, Gascoigne NRJ, Johnson HM. 1992. T-cell antigen receptor binding sites for the microbial superantigen staphylococcal enterotoxin A. Proc Natl Acad Sci USA 89:7727-7731.
44. Prasad GS, Earhart CA, Murray DL, Novick RP, Schlievert PM, Ohlendorf DH. 1993. Structure of toxic shock syndrome toxin-1. Biochemistry 32:13761-13766.
45. Rowley AH, Gonzalez-Crussi F, Shulman ST. 1991. Kawasaki syndrome. Curr Probl Pediatr 21:387-405.
46. Ruff M, Krishnaswamy S, Boeglin M, Potuszman A, Mitchler A, Podgainy A, Rees B, Thierry JC, Moras D. 1991. Class II aminoacyl transfer RNA synthetases: Crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp). Science 252:1692-1689.
47. Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA. 1995. Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J 14:3292-3301.
48. Schindelin H, Marahiel MA, Heinemann U. 1993. Universal nucleic acid-binding domain revealed by the crystal structure of the B. subtilis major cold-shock protein. Nature 364:164-168.
49. Schlievert PM, Shands KN, Dan BB, Schmid GP, Nishimura RD. 1981. Identification and characterization of an exotoxin from Staphylococcus aureus associated with toxic shock syndrome. J Infect Dis 143:509-516.
50. Shands KN, Schmid GP, Dan BB, Blum D, Guidotti RJ, Hargrett NT, Anderson RL, Hill DL, Broome CV, Band JD, Fraser DW. 1980. Toxic-shock syndrome in menstruating women: Association with tampon use and Staphylococcus aureus and clinical features in 52 cases. N Engl J Med 303:1436-1442.
51. Sixma TK, Pronk SE, Kalk KH, van Zanten BA, Witholt B, Hol WG. 1992. Crystal structure of a cholera toxin-related heat-labile enterotoxin from E. coli. Nature 351:671-677.
52. Stein PE, Boodhoo A, Armstrong GD, Cockle SA, Klein MH, Read RJ. 1994. The crystal structure of pertussis toxin. Structure 2:45-57.
53. Stein PE, Boodhoo A, Tyrrell GJ, Brunton JL, Read RJ. 1992. Crystal structure of the cell-binding B oligomer of verotoxin-1 from E. coli. Nature 355:748-750.
54. Stiles BG, Krakauer T, Bonventre PF. 1995. Biological activity of toxic shock syndrome toxin 1 and a site-directed mutant, H135A, in a lipopolysaccharide-potentiated mouse lethality model. Infect Immun 63:1229-1234.
55. Swaminathan S, Furey W, Pletcher J, Sax M. 1992. Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature 359:801-806.
56. Swaminathan S, Furey W, Pletcher J, Sax M. 1995. Residues defining Vβ specificity in staphylococcal enterotoxins. Nat Struct Biol 2:680-686.
57. Williamson RA, Martorell G, Carr MD, Murphy G, Docherty AJP, Freedman RB, Feeney J. 1994. Solution structure of the active domain of tissue inhibitor of metalloproteinase-2. A new member of the OB fold protein family. Biochemistry 33:11745-11759.
58. Zhang XJ, Wozniak JA, Matthews BW. 1995. Protein flexibility and adaptability seen in 25 crystal forms of T4 lysozyme. J Mol Biol 250:527-552.