The solution structure of the Raf-1 cysteine-rich domain: A novel Ras and phospholipid binding site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 16, 1996, Pages 8312-8317

  Mott, Helen R ^a   Carpenter, John W ^a   Zhong, Sheng ^a   Ghosh, Sujoy ^b   Bell, Robert M ^b   Campbell, Sharon L ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b GLAXOSMITHKLINE   (United States)

Author keywords

nuclear magnetic resonance; protein kinase C; signal transduction; zinc

Indexed keywords

CYSTEINE; DIACYLGLYCEROL; PHORBOL ESTER; PHOSPHATIDYLSERINE; PHOSPHOLIPID; PROTEIN KINASE C; RAF PROTEIN; RAS PROTEIN; ZINC;

ARTICLE; BINDING SITE; LIGAND BINDING; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE; HYDROGEN BONDING; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHOLIPIDS; PROTEIN BINDING; PROTEIN KINASE C; PROTEIN STRUCTURE, SECONDARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-RAF; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SOLUTIONS;

EID: 0029757119     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.16.8312     Document Type: Article

References (53)

1. Daum, G., Eisenmann-Tappe, I., Fries, H.-W., Troppmair, J. & Rapp, U. R. (1994) Trends Biochem. Sci. 19, 474-480.
2. Clark, G. J. & Der, C. J. (1993) in Regulatory GTP Binding Proteins, eds. Dickey, B. & Birnbaumer, L. (Springer, Heidelberg), pp. 259-287.
3. Crews, C. M. & Erikson, K. L. (1993) Cell 74, 215-217.
4. Avruch, J., Zhang, X. F. & Kyriakis, J. M. (1994) Trends Biochem. Sci. 19, 279-283.
5. Leavers, S. J., Paterson, H. F. & Marshall, C. J. (1994) Nature (London) 369, 411-413.
6. Stokoe, D., Macdonald, S. G., Cadwallader, K., Symons, M. & Hancock, J. F. (1994) Science 264, 1463-1466.
7. Stanton, V. P., Nichols, D. W., Laudano, A. P. & Cooper, G. M. (1989) Mol. Cell. Biol. 9, 639-647.
8. Heidecker, G., Huleihel, M., Cleveland, J. L., Kolch, W., Beck, T. W., Lloyd, P., Pawson, T. & Rapp, U. R. (1990) Mol. Cell. Biol. 10, 2503-2512.
9. Ishikawa, F., Sakai, R., Ochiai, M., Takaku, F., Sugimura, T. & Nagao, M. (1988) Oncogene 3, 653-658.
10. Chuang, E., Barnard, D., Hettich, L., Zhang, X.-F., Avruch, J. & Marshall, M. S. (1994) Mol. Cell. Biol. 14, 5318-5325.
11. Vojtek, A. B., Hollenberg, S. M. & Cooper, J. A. (1993) Cell 74, 205-514.
12. Emerson, S. D., Madison, V. S., Palermo, R. E., Waugh, D. S., Scheffler, J. E., Tsao, K.-L., Kiefer, S. E., Liu, S. P. & Fry, D. C. (1995) Biochemistry 34, 6911-6918.
13. Nassar, N., Horn, G., Herrmann, C., Scherer, A., McCormick, F. & Wittinghofer, A. (1995) Nature (London) 375, 554-560.
14. Ghosh, S., Qin Xie, W., Quest, F. G., Mabrouk, G. M., Strum, J. C. & Bell, R. M. (1994) J. Biol. Chem. 269, 10000-10007.
15. Ghosh, S. & Bell, R. M. (1994) J. Biol. Chem. 269, 30785-30788.
16. Brtva, T. R., Drugan, J. K., Ghosh, S., Terrell, R. S., Campbell-Burk, S., Bell, R. M. & Der, C. J. (1995) J. Biol. Chem. 270, 9809-9812.
17. Hu, C-D., Kariya, K., Tamada, M., Akasaka, K., Shirouzu, M., Yokoyama, S. & Kataoka, T. (1995) J. Biol. Chem. 270, 30274-30277.
18. Drugan, J. K., Khosravi-Far, R., White, M. A., Der, C. J., Sung, Y.-J., Hwang, Y.-W. & Campbell, S. L. (1996) J. Biol. Chem. 271, 233-237.
19. Freed, E., Symons, M., Macdonald, S. G., McCormick, F. & Ruggieri, R. (1994) Science 265, 1713-1716.
20. Irie, K., Gotoh, Y., Yashar, B. M., Errede, B., Nishida, E. & Matsumoto, K. (1994) Science 265, 1716-1719.
21. Fu, H., Xia, K., Palla, D. C., Cui, C., Conroy, K., Narsimhan, R. P., Mamon, H., Collier, R. J. & Roberts, T. M. (1994) Science 266, 126-129.
22. Fantl, W. J., Muslin, A. J., Kikuchi, A., Martin, J. A., MacNicol, A. M., Gross, R. W. & Williams, L. T. (1994) Nature (London) 371, 612-614.
23. Li, S., Janosch, P., Tanji, M., Rosenfeld, G. C., Waymire, J. C., Mischak, H., Kolch, W. & Sedivy, J. M. (1995) EMBO J. 14, 685-696.
24. Luo, Z.-J., Zhang, X.-F., Rapp, U. & Avruch, J. (1995) J. Biol. Chem. 270, 23681-23687.
25. Chow, Y. H., Pulmiglia, K., Jun, T. H., Dent, P., Sturgill, T. W. & Jove, R. (1995) J. Biol. Chem. 270, 14100-14106.
26. Lu, X., Chou, T.-B., Williams, N. G., Roberts, T. & Perriman, N. (1993) Genes Dev. 7, 621-632.
27. Ono, Y., Fujii, T., Igarashi, K., Takayoshi, K., Tanaka, C., Kikkawa, U. & Nishizuka, Y. (1989) Proc. Natl. Acad. Sci. USA 86, 4868-4871.
28. Lee, J., Ahmed, S., Kozma, R., Teo, M., Monfries, C. & Lim, L. (1992) Biochem. Soc. Trans. 20, 310S.
29. Schaap, D., de Widt, J., van der Wal, J., Vandekerckhove, J., van Damme, J., Gussow, D., Pleogh, H., van Blittenswijk, W. J. & van der Bend, R. L. (1990) FEBS Lett. 275, 151-158.
30. Coppola, J., Bryant, S., Koda, T., Conway, D. & Barbacid, M. (1991) Cell Growth Differ. 2, 95-105.
31. Ahmed, S., Kozma, R., Monfries, C., Harden, N. & Lim, L. (1991) Biochem. J. 280, 233-241.
32. Hommel, U., Zurini, M. & Luyten, M. (1994) Nat. Struct. Biol. 1, 383-387.
33. Zhang, G., Kazanietz, M. G., Blumberg, P. M. & Hurley, J. H. (1995) Cell 81, 917-924.
34. Driscoll, P. C, Clore, G. M. & Marion, D. (1990) Biochemistry 29, 3542-3556.
35. Kay, L. E., Keifer, P. & Saarinen, T. (1992) J. Am. Chem. Soc. 114, 10663-10665.
36. Marion, D., Driscoll, P. C., Kay, L. C., Wingfield, P. T., Bax, A., Gronenborn, A. M. & Clore, G. M. (1989) Biochemistry 28, 6150-6156.
37. Shaka, A. J., Lee, C. J. & Pines, A. (1988) J. Magn. Reson. 77, 274-293.
38. Piotto, M., Saudek, V. & Sklenar, V. (1992) J. Biomol. NMR 2, 661-665.
39. Rance, M., Sorenson, O. W., Bodenhausen, G., Wagner, G., Ernst, R. R. & Wüthrich, K. (1983) Biochem. Biophys. Res. Commun. 117, 479-485.
40. Braunschweiler, L. & Ernst, R. R. (1983) J. Magn. Reson. 53, 521-528.
41. Jeener, J., Meier, B. H., Bachmann, P. & Ernst, R. R. (1979) J. Chem. Phys. 71, 4546-4553.
42. Billeter, M., Neri, D., Otting, G., Qian, Y. Q. & Wüthrich, K. (1992) J. Biomol. NMR 2, 257-274.
43. Mueller, L. (1987) J. Magn. Reson. 72, 191-197.
44. Brunger, A. T. (1992) X-PLOR: A System for X-ray Crystallography and NMR (Yale Univ. Press, New Haven, CT).
45. Pelton, J. G., Torchia, D. A., Meadow, N. D. & Roseman, S. (1993) Protein Sci. 2, 543-558.
46. Diakun, G. P., Fairall, L. & Klug, A. (1986) Nature (London) 324, 698-699.
47. Wüthrich, K. (1986) NMR of Proteins and Nucleic Acids (Wiley, New York).
48. Blomberg, F., Maurer, W. & Rüterjans, H. (1977) J. Am. Chem. Soc. 99, 8149-8159.
49. Kraulis, P. J. (1993) J. Appl. Crystallogr. 24, 946-950.
50. Clark, G. J., Drugan, J. K., Terrell, R. S., Bradham, C., Der, C. J., Bell, R. M. & Campbell-Burk, S. (1996) Proc. Natl. Acad. Sci. USA 93, 1577-1581.
51. Kazanietz, M. G., Wang, S., Milne, G. W. A., Lewin, N. E., Liu, H. L. & Blumberg, P. M. (1995) J. Biol. Chem. 270, 21852-21859.
52. Newton, A. C. (1995) J. Biol. Chem. 270, 28495-28498.
53. Bell, R. M. & Burns, D. J. (1991) J. Biol. Chem. 266, 4661-4664.