The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization

EMBO Journal

Volumn 15, Issue 24, 1996, Pages 6832-6840

  Sundström, Michael ^a   Abrahmsén, Lars ^a   Antonsson, Per ^b   Mehindate, Khalil ^c   Mourad, Walid ^c   Dohlsten, Mikael ^b  

^a PFIZER INC   (United States)

^b Pharmacia & Upjohn AB   (Sweden)

^c LAVAL UNIVERSITY   (Canada)

Author keywords

MHC class II molecules; Staphylococcal enterotoxin D; Superantigen; X ray crystallography

Indexed keywords

CYTOKINE; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; STAPHYLOCOCCUS ENTEROTOXIN; SUPERANTIGEN; ZINC;

AMINO TERMINAL SEQUENCE; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROSS LINKING; CRYSTAL STRUCTURE; DIMERIZATION; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; THREE DIMENSIONAL IMAGING; TOXIN STRUCTURE; X RAY CRYSTALLOGRAPHY;

BINDING SITES; BIOPOLYMERS; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SUPERANTIGENS; TUMOR CELLS, CULTURED; ZINC;

EID: 0030462562     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01074.x     Document Type: Article

References (35)

1. Abrahmsén,L., Dohlsten,M., Segrén,S., Björk,P., Jonsson,E. and Kalland,T. (1995) Characterization of two distinct MHC class II binding sites in the superantigen staphylococcal enterotoxin A. EMBO J., 14, 2978-2986.
2. Acharya,K.R., Passalacqua,E.F., Jones,E.Y., Harlos,K., Stuart,D.I., Brehm,R.D. and Tranter,H.S. (1994) Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1. Nature, 367, 94-97.
3. Bayles,K.W. and Iandolo,J.J. (1989) Genetic and molecular analyses of the gene encoding staphylococcal enterotoxin D. J. Bacteriol., 171, 4799-4806.
4. Betley,M.J. and Mekalanos,J.J. (1988) Nucloetide sequence of the type A staphylococcal enterotoxin gene. J. Bacteriol., 170, 34-41.
5. Brünger,A.T. (1992a) Free R value: a novel statistical quantity for assessing the accuracy of crystal structures. Nature, 355, 472-475.
6. Brünger,A.T. (1992b) X-PLOR Manual. Yale University Press, New Haven, CT.
7. Brünger,A.T., Karplus,M. and Petsko,G.M. (1989) Crystallographic refinement by simmulated annealing: application to crambin. Acta Crystallogr., A45, 50-61.
8. CCP4 (1994) The CCP4 suite: programs for protein crystallography. Acta Crystallogr., D50, 760-763.
9. Coull,J., Pappin,D., Mark,J., Aebersold,R. and Köster,K. (1991) Functionalized membrane supports for covalent protein microsequence analysis. Anal Biochem., 194, 110-120.
10. Dohlsten,M., Hedlund,G., Åkerblom,E., Lando,P.A. and Kalland,T. (1991) Monoclonal antibody-targeted superantigens: a different class of anti-tumor agents. Proc. Natl Acad. Sci. USA, 88, 9287-91.
11. Dohlsten,M., Abrahmsen,L., Bjork,P., Lando,P.A., Hedlund,G., Forsberg,G., Brodin,T., Gascoigne,N.R., Förberg,C., Lind,P. and Kalland,T. (1994) Monoclonal antibody-superantigen fusion proteins: tumor-specific agents for T-cell based tumor therapy. Proc. Natl Acad. Sci. USA, 91, 8945-8949.
12. Fraser,J., Urban,R., Strominger,J. and Robinson,H. (1992) Zinc regulates the function of two superantigens. Proc. Natl Acad. Sci. USA, 89, 5507-5511.
13. Herman,A., Labrecque,N., Thibodeau,J., Marrack,P., Kappler,J.W. and Sekaly,R.P. (1991) Identification of the staphylococcal enterotoxin A superantigen binding site in the beta 1 domain of the human histocompatibility antigen HLA-DR. Proc. Natl Acad. Sci. USA, 88, 9954-9958.
14. Hudson,K.R., Tiedemann,R.E., Urban,R.G., Lowe,S.C. Strominger,J.L. and Fraser,J.D. (1995) Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II. J. Exp. Med., 182, 711-720.
15. Jardetzky,T.S., Brown,J.H., Gorga,J.C., Stern,L.J., Urban,R.G., Chi,Y.I., Stauffacher,C., Strominger,J.L. and Wiley,D.C. (1994) Three-dimensional structure of a human class II histocompatibility molecule complexed with superantigen. Nature, 368, 711-718.
16. Jones,T.A., Zou,J.Y., Cowan,S.W. and Kjeldgaard,M. (1991) Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr., A47, 110-119.
17. Kabsch,W. (1988) Evaluation of single-crystal X-ray diffraction data from a position sensitive detector. J. Appl. Crystallogr., 21, 916-924.
18. Kabsch,W. and Sander,C. (1983) Dictionary of protein secondary structure: pattern recognition of hydrogen bonded and geometrical features. Biopolymers. 22, 2577-2637.
19. Karp,D.R. and Long,E.O. (1992) Identification of HLA-DR1 beta chain residues critical for binding staphylococcal enterotoxins A and E. J. Exp. Med., 175, 415-424.
20. Kim,J., Urban,R.G., Strominger,J.L. and Wiley,D.C. (1994) Toxic shock syndrome toxin-1 complexed with a class II major histocompatibility molecule HLA-DR1. Science, 266, 1870-1874.
21. Kraulis,P.J. (1991) MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr., 24, 945-950.
22. Laskowski,R.A., MacArthur,M.W., Moss,D.S. and Thornton,J.M. (1993) PROCHECK: a program to check the stereochemistry of protein structures. J. Appl. Crystallogr., 26, 283-291.
23. Marrack,P. and Kappler,J. (1990) The staphylococcal enterotoxins and their relatives. Science, 248, 705-711.
24. Mehindate,K.M., Thibodeau,J., Dohlsten,M., Kalland,T., Sekaly,R.-P. and Mourad,W. (1995) Cross-linking of major histocompatibility complex class II molecules by staphylococcal enterotoxin A superantigen is a requirement for inflammatory cytokine gene expression. J. Exp. Med., 182, 1573-1577.
25. Merritt,E.A. and Murphy,M.E.P. (1994) Raster 3D Version 2.0. A program for photorealistic molecular graphics. Acta Crystallogr., D50, 869-873.
26. Navaza,J. (1994) AMoRe: an automated package for molecular replacement. Acta Crystallogr., A50, 157-163.
27. Papageorgiou,A.C., Acharya,K.R., Shapiro,R., Passalacqua,E.F., Brehm,R.D. and Tranter,H.S. (1995) Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site. Structure, 3, 769-779.
28. Prasad,G.S., Earhart,C.A., Murray,D.L., Novick,R.P., Schlievert,P.M. and Ohlendorf,D.H. (1993) Structure of toxic shock syndrome toxin 1. Biochemistry, 32, 13761-13766.
29. Sambrook,J., Fritsch,E.F. and Maniatis,T. (1989) Molecular Cloning: A Laboratory Manual, 2nd edn. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, NY.
30. Schad,E.M., Zaitseva,I., Zaitsev,V.N., Dohlsten,M., Kalland,T., Schlievert,P.M., Ohlendorf,D.H. and Svensson L.A. (1995) Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J., 14, 3292-3301.
31. 2+ at 2.7 Å resolution. J. Biol. Chem., 271, 32212-32216.
32. Swaminathan,S., Furey,W., Pletcher,J. and Sax,M. (1992) Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature, 359, 801-806.
33. Thompson,G.A. and Carpenter,F.H. (1976) Leucine aminopeptidase (bovine lens). The relative binding of cobalt and zinc to leucine aminopeptidase and the effect of cobalt substitution on specific activity. J. Biol. Chem., 251, 1618-1624.
34. Valleé,B.L. and Auld,D.S. (1990) Zinc coordination, function and structure of zinc enzymes and other proteins. Biochemistry, 29, 5647-5659.
35. von Heijne,G. (1986) A new method for predicting signal sequence cleavage sites. Nucleic Acids Res., 14, 4683-4690.