Structural consequences of the active site substitution Cys181 → Ser in metallo-β-lactamase from Bacteroides fragilis

Protein Science

Volumn 8, Issue 1, 1999, Pages 249-252

  Li, Zhong ^a   Rasmussen, Beth A ^b   Herzberg, Osnat ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

^b PFIZER INC   (United States)

Author keywords

Binuclear metal center; Metallo lactamase; Site directed mutagenesis; X ray crystallography

Indexed keywords

BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CADMIUM; CARBOXYLIC ACID; CYSTEINE; DIVALENT CATION; HYDROXIDE; METALLOPROTEIN; MUTANT PROTEIN; SERINE; WATER; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; ATOMIC ABSORPTION; BACTEROIDES FRAGILIS; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL;

EID: 0032951167     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.1.249     Document Type: Article

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