Inducible nitric oxide synthase: Role of the N-terminal β-hairpin hook and pterin-binding segment in dimerization and tetrahydrobiopterin interaction

EMBO Journal

Volumn 18, Issue 22, 1999, Pages 6260-6270

  Ghosh, Dipak K ^a,b   Crane, Brian R ^c,d   Ghosh, Sanjay ^a   Wolan, Dennis ^a   Gachhui, Ratan ^a   Crooks, Carol ^a   Presta, Anthony ^a   Tainer, John A ^c   Getzoff, Elizabeth D ^c   Stuehr, Dennis J ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b DUKE UNIVERSITY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

hairpin hook; Dimer; Heme protein; Nitric oxide; Oxidoreductase

Indexed keywords

ALANINE; ARGININE; DIMER; HEME; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXYGENASE; PROTEIN SUBUNIT; PTERIN; TETRAHYDROBIOPTERIN; ZINC;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CONTROLLED STUDY; DELETION MUTANT; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME INDUCTION; ENZYME SUBSTRATE COMPLEX; HYDROGEN BOND; MUTAGENESIS; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BIOPTERIN; CATTLE; DIMERIZATION; DROSOPHILA; HUMANS; KINETICS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; POINT MUTATION; PROTEIN STRUCTURE, SECONDARY; PTERINS; RATS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE DELETION; SEQUENCE HOMOLOGY, AMINO ACID; SPECTROPHOTOMETRY;

EID: 0033571213     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/18.22.6260     Document Type: Article

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