Crystal structure of the stromelysin catalytic domain at 2.0 Å resolution: Inhibitor-induced conformational changes

Journal of Molecular Biology

Volumn 293, Issue 3, 1999, Pages 545-557

  Chen, Longyin ^a   Rydel, Timothy J ^a   Gu, Fei ^a   Dunaway, C Michelle ^a   Pikul, Stanislaw ^a   Dunham, Kelly McDow ^a   Barnett, B L ^a  

^a PROCTER AND GAMBLE COMPANY   (United States)

Author keywords

Matrix metalloproteinase; Osteoarthritis; Protein crystal structure; Stromelysin; Structure based drug design

Indexed keywords

CALCIUM ION; MATRIX METALLOPROTEINASE; STROMELYSIN; THREONINE; TYROSINE; ZINC;

ARTICLE; CANCER INVASION; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME ACTIVE SITE; ENZYME STRUCTURE; HUMAN; HYDROPHOBICITY; OSTEOARTHRITIS; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION;

PYRONIA TITHONUS;

EID: 0032712582     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1999.3147     Document Type: Article

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