Crystal structure of the IMP-1 metallo β-lactamase from Pseudomonas aeruginosa and its complex with a mercaptocarboxylate inhibitor: Binding determinants of a potent, broad-spectrum inhibitor

Biochemistry

Volumn 39, Issue 15, 2000, Pages 4288-4298

  Concha, Néstor O ^a,c   Janson, Cheryl A ^a   Rowling, Pam ^a   Pearson, Stewart ^a   Cheever, Christy A ^a   Clarke, Brian P ^a   Lewis, Ceri ^a   Galleni, Moreno ^b   Frère, Jean Marie ^b   Payne, David J ^a   Bateson, John H ^a   Abdel Meguid, Sherin S ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c Mail Code UE0447 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; BACTERIAL ENZYME; BETA LACTAMASE; BETA LACTAMASE INHIBITOR;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME STRUCTURE; ENZYME SUBSTRATE; ESCHERICHIA COLI; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

BETA-LACTAMASES; BINDING SITES; CONSERVED SEQUENCE; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ELECTROSTATICS; ENZYME INHIBITORS; GLYCINE; HYDROGEN BONDING; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; PSEUDOMONAS AERUGINOSA; SUBSTRATE SPECIFICITY; TETRAZOLES; WATER; ZINC;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA;

EID: 0034681922     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992569m     Document Type: Article

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