X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily

Structure

Volumn 4, Issue 4, 1996, Pages 375-386

  Dhanaraj, V ^a   Ye, Q Z ^b   Johnson, L L ^b   Hupe, D J ^b   Ortwine, D F ^b   Dunbar Jr , J B ^b   Rubin, J R ^b   Pavlovsky, A ^b   Humblet, C ^b   Blundell, T L ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b PFIZER INC   (United States)

Author keywords

Hydroxamate inhibitor; Matrix metalloproteinase 3 (MMP 3); Metzincin; Stromelysin; Zinc dependent metalloproteinase superfamily

Indexed keywords

ASTACIN; COLLAGENASE; CROTALUS ADAMANTEUS PROTEINASE II; ENZYME INHIBITOR; HYDROXAMIC ACID; METALLOPROTEINASE; PD 140798; SERRALYSIN; STROMELYSIN; ZINC;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM; MOLECULAR GENETICS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY; X RAY CRYSTALLOGRAPHY;

AMINO ACID SEQUENCE; BINDING SITES; COLLAGENASES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HYDROXAMIC ACIDS; MAGNETIC RESONANCE SPECTROSCOPY; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; ZINC;

EID: 0030584673     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(96)00043-3     Document Type: Article

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