Mono- and binuclear Zn2+-β-lactamase. Role of the conserved cysteine in the catalytic mechanism

Journal of Biological Chemistry

Volumn 274, Issue 19, 1999, Pages 13242-13249

  Paul Soto, Raquel ^a,b   Bauer, Rogert ^d   Frère, Jean Marie ^b   Galleni, Moreno ^b   Meyer Klaucke, Wolfram ^c   Nolting, Hans ^c   Rossolini, Gian Maria ^e   De Seny, Dominique ^b   Hernandez Valladares, Maria ^a   Zeppezauer, Michael ^a   Adolph, Hans Werner ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b UNIVERSITY OF LIÈGE   (Belgium)

^c DESY   (Germany)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e UNIVERSITY OF SIENA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; NITROCEFIN; PENICILLIN G; CEPHALOSPORIN DERIVATIVE; CYSTEINE; PRIMER DNA; ZINC;

ANTIBIOTIC RESISTANCE; ARTICLE; BACILLUS CEREUS; BACTERIAL VIRULENCE; CONFORMATIONAL TRANSITION; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME CONFORMATION; ENZYME SPECIFICITY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; BINDING SITE; CATALYSIS; CHEMISTRY; ENZYMOLOGY; GENETICS; HYDROLYSIS; KINETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY;

BACILLUS CEREUS; BASE SEQUENCE; BETA-LACTAMASES; BINDING SITES; CATALYSIS; CEPHALOSPORINS; CYSTEINE; DNA PRIMERS; HYDROLYSIS; KINETICS; MUTAGENESIS, SITE-DIRECTED; PENICILLIN G; PROTEIN BINDING; PROTEIN CONFORMATION; SPECTROMETRY, X-RAY EMISSION; ZINC;

EID: 0033531792     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.19.13242     Document Type: Article

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