Kinetic properties and metal content of the metallo-β-lactamase CcrA harboring selective amino acid substitutions

Journal of Biological Chemistry

Volumn 274, Issue 22, 1999, Pages 15706-15711

  Yang, Youjun ^a   Keeney, David ^a   Tang, Xue Jun ^a   Canfield, Norman ^a   Rasmussen, Beth A ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,10 PHENANTHROLINE; 6 (1 METHYL 1,2,3 TRIAZOL 4 YLMETHYLENE)PENEM 3 CARBOXYLIC ACID; BETA LACTAMASE; CEFALORIDINE; IMIPENEM; METALLO BETA LACTAMASE CCRA3; PENICILLIN G; TAZOBACTAM; UNCLASSIFIED DRUG; ZINC;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; DRUG HYDROLYSIS; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; MASS SPECTROMETRY; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

AMINO ACIDS; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; CEPHALORIDINE; IMIPENEM; KINETICS; MASS SPECTROMETRY; METALLOPROTEINS; MODELS, MOLECULAR; MUTATION; PENICILLINS; PROTEIN BINDING; PROTEIN DENATURATION; SEQUENCE DELETION; ZINC;

FELIS CATUS;

EID: 0033056949     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.22.15706     Document Type: Article

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