Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase

Journal of Molecular Biology

Volumn 286, Issue 3, 1999, Pages 851-860

  Ploom, Tarmo ^a   Thöny, Beat ^b   Yim, Jeongbin ^c   Lee, Soojin ^c   Nar, Herbert ^a   Leimbacher, Walter ^b   Richardson, John ^a   Huber, Robert ^a   Auerbach, Günter ^a  

^a MAX PLANCK INSTITUTE OF BIOCHEMISTRY   (Germany)

^b Universitats Kinderklinik   (Switzerland)

^c Seoul National University   (South Korea)

Author keywords

6 Pyruvoyl tetrahydropterin synthase; Catalytic triad; Enzyme mechanism; Hyperphenylalaninaemia; Trahydrobiopterin

Indexed keywords

DYSPROPTERIN; HISTIDINE; HYDROXYL GROUP; MUTANT PROTEIN; PHOSPHATE; SYNTHETASE; TETRAHYDROBIOPTERIN; ZINC ION;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE COMPLEX; NONHUMAN; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

EID: 0345222533     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2511     Document Type: Article

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