Structure of streptococcal pyrogenic exotoxin A reveals a novel metal cluster

Protein Science

Volumn 9, Issue 9, 2000, Pages 1847-1851

  Earhart, Cathleen A ^a   Vath, Gregory M ^a   Roggiani, Manuela ^a   Schlievert, Patrick M ^a   Ohlendorf, Douglas H ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Cadmium; Metal cluster; Metal selectivity; Streptococcus pyogenes; Superantigens; Toxin; Zinc

Indexed keywords

CADMIUM; DISULFIDE; EXOTOXIN; EXOTOXIN A; EXOTOXIN B; GAMMA EXOTOXIN; LIGAND; METAL COMPLEX; PYROGEN; SUPERANTIGEN; UNCLASSIFIED DRUG; ZINC COMPLEX;

ARTICLE; BINDING SITE; CLINICAL FEATURE; CRYSTAL STRUCTURE; FEVER; NONHUMAN; PRIORITY JOURNAL; RASH; SCARLET FEVER; SEPTIC SHOCK; STAPHYLOCOCCUS; STREPTOCOCCUS PYOGENES; STRUCTURE ANALYSIS; TOXIC SHOCK SYNDROME; TOXIN STRUCTURE;

EID: 0033814760     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.9.9.1847     Document Type: Article

References (23)

1. Characterization of two distinct MHC class II binding sites in the super-antigen staphylococcal enterotoxin A
2. Structural basis of superantigen action inferred from crystal structure of toxic-shock syndrome toxin-1
3. Iron-sulfur clusters: Nature's modular, multipurpose structures
4. Staphylococcal enterotoxins, toxic shock syndrome toxin and streptococcal pyrogenic exotoxins: A comparative study of their molecular biology
5. Free R value: A novel statistical quantity for assessing the accuracy of crystal structures
6. Crystallography and NMR system: A new software suite for macromolecular structure determination
7. Crystal structure of a T-cell receptor β-chain complexed with a superantigen
8. Zinc regulates the function of two superantigens
9. Predictions of T-cell receptor- and major histocompatibility complex-binding sites on staphylococcal enterotoxin C1
10. Use of an imaging proportional counter in macromolecular crystallography
11. Staphylococcal enterotoxin A has two cooperative binding sites on major histocompatibility complex class II
12. PROCHECK: A program to check the stereochemical quality of protein structures
13. OB(oligonucleotide/oligosaccharide binding)-fold: Common structural and functional solution for non-homologous sequences
14. Streptococcus pyogenes causing toxic-shock-like syndrome and other invasive diseases: Clonal diversity and pyrogenic exotoxin expression
15. Comparison of three-dimensional structures of homologous proteins
16. Crystal structure of the superantigen enterotoxin C2 from Staphylococcus aureus reveals a zinc-binding site
17. Structural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors
18. Structure of toxic shock syndrome toxin 1
19. Refined crystal structure of Cd, Zn metallothionein at 2.0 A resolution
20. Crystal structure of the streptococcal superantigen SPE-C: Dimerization and zinc binding suggest a novel mode of interaction with MHC class II molecules
21. Crystal structure of the superantigen staphylococcal enterotoxin type A