A unique zinc-binding site revealed by a high-resolution X-ray structure of homotrimeric Apo2L/TRAIL

Biochemistry

Volumn 39, Issue 4, 2000, Pages 633-640

  Hymowitz, Sarah G ^a   O'Connell, Mark P ^a   Ultsch, Mark H ^a   Hurst, Amy ^a   Totpal, Klara ^a   Ashkenazi, Avi ^a   De Vos, Abraham M ^a   Kelley, Robert F ^a  

^a Greentech Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; APOPTOSIS INDUCING LIGAND 2; CYSTEINE; CYTOKINE; OLIGOMER; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; ZINC ION;

APOPTOSIS; ARTICLE; BINDING SITE; METAL BINDING; MOLECULAR MODEL; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN STABILITY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

ALANINE; AMINO ACID SEQUENCE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; BINDING SITES; CIRCULAR DICHROISM; CRYSTALLOGRAPHY, X-RAY; DNA MUTATIONAL ANALYSIS; HUMANS; LIGANDS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SPECTROMETRY, FLUORESCENCE; STRUCTURE-ACTIVITY RELATIONSHIP; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA; ZINC;

EID: 0034142219     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992242l     Document Type: Article

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