The X-ray crystal structure of phosphomannose isomerase from Candida albicans at 1.7 Å resolution

Nature Structural Biology

Volumn 3, Issue 5, 1996, Pages 470-479

  Cleasby, Anne ^a   Wonacott, Alan ^a   Skarzynski, Tadeusz ^a   Hubbard, Roderick E ^b   Davies, Gideon J ^b   Proudfoot, Amanda E I ^c   Bernard, Alain R ^c   Payton, Mark A ^c   Wells, Timothy N C ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF YORK   (United Kingdom)

^c GLAXO INST FOR MOLECULAR BIOLOGY   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIFUNGAL AGENT; FRUCTOSE 6 PHOSPHATE; MANNOSE 6 PHOSPHATE; MANNOSE PHOSPHATE ISOMERASE; ZINC;

CANDIDA ALBICANS; CRYSTAL STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; REVIEW; X RAY CRYSTALLOGRAPHY;

BINDING SITES; CANDIDA ALBICANS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MANNOSE-6-PHOSPHATE ISOMERASE; METALLOPROTEINS; MODELS, MOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; ZINC;

CANDIDA ALBICANS;

EID: 0029988489     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0596-470     Document Type: Article

References (18)

1. Orlean, P. Dolichol phosphate mannose synthase is required in vivo for glycosyl phosphatidylinositol membrane anchoring, O-mannosylation and N-glycosylation of protein in Saccharomyces cerevisiae. Mol. Cell. Biol. 10, 5796-5805 (1990).
2. Payton, M.A., Rheinecker, M., Klig, L.S., De Tiani, M. & Bowden, E. A novel Saccheromyces cerevisiae mutant possesses a thermolabile phosphomannose isomerase. J. Bacteriol. 173, 2005-2010 (1991).
3. Smith, D.J., Proudfoot, A.E.I., De Tiani, M., Wells, T.N.C. & Payton, M.A. Cloning and heterologous expression of the Candida albicans gene PMI 1 encoding phosphomannose isomerase. Yeast 11, 301-310 (1995).
4. Manfredi, R., Nanetti, A., Mazzoni, A., Mastroianni, A. & Chiodo, F. The incidence, etiology and clinical significance of visceral mycoses in patients with AIDS. Minerva Medica 84, 383-391 (1993).
5. Proudfoot, A.E.I., Payton, M.A. & Wells, T.N.C. Purification and characterisation of fungal and mammalian phosphomannose isomerases. J. Protein Chem. 13 619-627 (1994).
6. Proudfoot, A.E.I., Turcatti, G., Wells, T.N.C., Payton, M.A. & Smith, D.J. Purification, cDNA cloning and heterologous expression of human phosphomannose isomerase. Eur. J. Biochem. 219, 415-413 (1994).
7. Shinabarger, D. et al. Purification and characterisation of phosphomannose isomerase-guanosine diphospho-D-mannose pyrophosphorylase. J. Biol. Chem. 266, 2080-2088 (1991).
8. Schmidt, M., Arnold, W., Niemann, A., Kleickmann, A. & Puhler, A. The Rhizobium meliloti pmi gene encodes a new type of phosphomannose isomerase. Gene, 122, 35-43 (1992).
9. Gracy, R.W. & Noltmann, E.A. Studies on phosphomannose isomerase. J. Biol. Chem. 243, 3161-3168 (1968).
10. Walsh, C. Enzmatic raction mehanisms (WH. Freeman & Co, New York, 1979).
11. Wells, T.N.C., Coulin, F., Payton, M.A. & Proudfoot, A.E.I. Phosphomannose Isomerase from Saccharomyces cerevisiae contains two inhibitory metal binding sites. Biochemistry 32, 1294-1301 (1993).
12. Wells, T.N.C., Payton, M.A. & Proudfoot, A.E.I. Inhibition of Phosphomannose isomerase by mercury ions. Biochemistry 33, 7641-7646 (1994).
13. Wells, T.N.C., Scully, P.A., Paravicini, G., Proudfoot, A.E.I. & Payton, M.A. Mechanism of irreversible inactivation of phosphomannose isomerase by silver ions and flammazine. Biochemistry 3, 7896-7903 (1995).
14. Tolley, S. et al. Crystallisation and preliminary X-ray analysis of Candida albicans Phosphomannose isomerase. J. Mol. Biol. 237, 349-350 (1994).
15. Richardson, J. S. The anatomy and taxonomy of protein structure. Adv. Protein Chem. 34, 167-339 (1981).
16. Rossmann, M.G. et al. Structural comparisons of some small spherical plant viruses. J. Mol. Biol. 165, 711-736 (1983).
17. Ko, T-P, Ng, J.D. and McPherson, A. The Three-Dimensional Structure of Canavalin from Jack Bean (Canavalia ensiformis). Plant Physiol. 101, 729-744 (1993).
18. Vallee, B.L. and Auld, D.S. Zinc co-ordination, function and structure of zinc enzymes and other proteins. Biochemistry 29, 5647-5659 (1990).