Reaction mechanism of glyoxalase I explored by an x-ray crystallographic analysis of the human enzyme in complex with a transition state analogue

Biochemistry

Volumn 38, Issue 41, 1999, Pages 13480-13490

  Cameron, Alexander D ^a,c   Ridderström, Marianne ^a   Olin, Birgit ^a   Kavarana, Malcolm J ^b   Creighton, Donald J ^b   Mannervik, Bengt ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b UNIVERSITY OF MARYLAND BALTIMORE COUNTY   (United States)

^c UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LACTOYLGLUTATHIONE LYASE;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME ANALYSIS; ENZYME BINDING; ENZYME MECHANISM; ENZYME STRUCTURE; PRIORITY JOURNAL; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

BINDING, COMPETITIVE; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; GLUTAMIC ACID; GLUTAMINE; GLUTATHIONE; HUMANS; LACTOYLGLUTATHIONE LYASE; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN CONFORMATION; ZINC;

EID: 0033550054     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990696c     Document Type: Article

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