-
1
-
-
0032491416
-
Embryonic stem cell lines derived from human blastocysts
-
Thomson JA, et al. Embryonic stem cell lines derived from human blastocysts. Science. 1998;282:1145–7.
-
(1998)
Science
, vol.282
, pp. 1145-1147
-
-
Thomson, J.A.1
-
2
-
-
84855397933
-
Concise review: Embryonic stem cells versus induced pluripotent stem cells: The game is on
-
Puri MC, Nagy A. Concise review: embryonic stem cells versus induced pluripotent stem cells: the game is on. Stem Cells. 2012;30:10–4.
-
(2012)
Stem Cells
, vol.30
, pp. 10-14
-
-
Puri, M.C.1
Nagy, A.2
-
4
-
-
84874980486
-
Closing the circle of germline and stem cells: The primordial stem cell hypothesis
-
Solana J. Closing the circle of germline and stem cells: the primordial stem cell hypothesis. Evodevo. 2013;4:2.
-
(2013)
Evodevo
, vol.4
, pp. 2
-
-
Solana, J.1
-
5
-
-
0000155376
-
The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles
-
Gurdon JB. The developmental capacity of nuclei taken from intestinal epithelium cells of feeding tadpoles. J Embryol Exp Morphol. 1962;10:622–40.
-
(1962)
J Embryol Exp Morphol
, vol.10
, pp. 622-640
-
-
Gurdon, J.B.1
-
6
-
-
0000042464
-
Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs
-
Briggs R, King TJ. Transplantation of living nuclei from blastula cells into enucleated frogs’ eggs. Proc Natl Acad Sci U S A. 1952;38:455–63.
-
(1952)
Proc Natl Acad Sci U S A
, vol.38
, pp. 455-463
-
-
Briggs, R.1
King, T.J.2
-
7
-
-
0031044215
-
Viable offspring derived from fetal and adult mammalian cells
-
Wilmut I, Schnieke AE, McWhir J, Kind AJ, Campbell KH. Viable offspring derived from fetal and adult mammalian cells. Nature. 1997;385:810–3.
-
(1997)
Nature
, vol.385
, pp. 810-813
-
-
Wilmut, I.1
Schnieke, A.E.2
McWhir, J.3
Kind, A.J.4
Campbell, K.H.5
-
8
-
-
36248966518
-
Induction of pluripotent stem cells from adult human fibroblasts by defined factors
-
Takahashi K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007;131:861–72.
-
(2007)
Cell
, vol.131
, pp. 861-872
-
-
Takahashi, K.1
-
9
-
-
84881186856
-
Genetic and epigenetic variations in iPSCs: Potential causes and implications for application
-
Liang G, Zhang Y. Genetic and epigenetic variations in iPSCs: potential causes and implications for application. Cell Stem Cell. 2013;13:149–59.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 149-159
-
-
Liang, G.1
Zhang, Y.2
-
10
-
-
79951694132
-
Meganucleases and other tools for targeted genome engineering: Perspectives and challenges for gene therapy
-
Silva G, et al. Meganucleases and other tools for targeted genome engineering: perspectives and challenges for gene therapy. Curr Gene Ther. 2011;11:11–27.
-
(2011)
Curr Gene Ther
, vol.11
, pp. 11-27
-
-
Silva, G.1
-
11
-
-
84880581726
-
Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in
-
Popplewell L, et al. Gene correction of a duchenne muscular dystrophy mutation by meganuclease-enhanced exon knock-in. Hum Gene Ther. 2013;24:692–701.
-
(2013)
Hum Gene Ther
, vol.24
, pp. 692-701
-
-
Popplewell, L.1
-
12
-
-
84893602397
-
Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN
-
Dupuy A, et al. Targeted gene therapy of xeroderma pigmentosum cells using meganuclease and TALEN. PLoS One. 2013;8, e78678.
-
(2013)
Plos One
, vol.8
-
-
Dupuy, A.1
-
13
-
-
0031911791
-
I-SceI-induced gene replacement at a natural locus in embryonic stem cells
-
Cohen-Tannoudji M, et al. I-SceI-induced gene replacement at a natural locus in embryonic stem cells. Mol Cell Biol. 1998;18:1444–8.
-
(1998)
Mol Cell Biol
, vol.18
, pp. 1444-1448
-
-
Cohen-Tannoudji, M.1
-
14
-
-
84873467162
-
Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases
-
Menoret S, et al. Generation of Rag1-knockout immunodeficient rats and mice using engineered meganucleases. FASEB J. 2013;27:703–11.
-
(2013)
FASEB J
, vol.27
, pp. 703-711
-
-
Menoret, S.1
-
15
-
-
27744530147
-
Zinc finger nucleases: Custom-designed molecular scissors for genome engineering of plant and mammalian cells
-
Durai S, et al. Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res. 2005;33:5978–90.
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 5978-5990
-
-
Durai, S.1
-
16
-
-
23444441147
-
Gene targeting using zinc finger nucleases
-
Porteus MH, Carroll D. Gene targeting using zinc finger nucleases. Nat Biotechnol. 2005;23:967–73.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 967-973
-
-
Porteus, M.H.1
Carroll, D.2
-
17
-
-
19544371373
-
Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century
-
Capecchi MR. Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century. Nat Rev Genet. 2005;6:507–12.
-
(2005)
Nat Rev Genet
, vol.6
, pp. 507-512
-
-
Capecchi, M.R.1
-
18
-
-
67749106611
-
Knockout rats via embryo microinjection of zinc-finger nucleases
-
Geurts AM, et al. Knockout rats via embryo microinjection of zinc-finger nucleases. Science. 2009;325:433.
-
(2009)
Science
, vol.325
, pp. 433
-
-
Geurts, A.M.1
-
19
-
-
77749273530
-
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases
-
Mashimo T, et al. Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One. 2010;5, e8870.
-
(2010)
Plos One
, vol.5
-
-
Mashimo, T.1
-
20
-
-
78651322138
-
Targeted integration in rat and mouse embryos with zinc-finger nucleases
-
Cui X, et al. Targeted integration in rat and mouse embryos with zinc-finger nucleases. Nat Biotechnol. 2011;29:64–7.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 64-67
-
-
Cui, X.1
-
21
-
-
84888044335
-
Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation
-
Ferguson C, McKay M, Harris RA, Homanics GE. Toll-like receptor 4 (Tlr4) knockout rats produced by transcriptional activator-like effector nuclease (TALEN)-mediated gene inactivation. Alcohol. 2013;47:595–9.
-
(2013)
Alcohol
, vol.47
, pp. 595-599
-
-
Ferguson, C.1
McKay, M.2
Harris, R.A.3
Homanics, G.E.4
-
22
-
-
78549267889
-
Targeted genome modification in mice using zinc-finger nucleases
-
Carbery ID, et al. Targeted genome modification in mice using zinc-finger nucleases. Genetics. 2010;186:451–9.
-
(2010)
Genetics
, vol.186
, pp. 451-459
-
-
Carbery, I.D.1
-
23
-
-
77957005768
-
Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases
-
Meyer M, de Angelis MH, Wurst W, Kuhn R. Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases. Proc Natl Acad Sci U S A. 2010;107:15022–6.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 15022-15026
-
-
Meyer, M.1
de Angelis, M.H.2
Wurst, W.3
Kuhn, R.4
-
24
-
-
0024433084
-
Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs
-
Brinster RL, et al. Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs. Proc Natl Acad Sci U S A. 1989;86:7087–91.
-
(1989)
Proc Natl Acad Sci U S A
, vol.86
, pp. 7087-7091
-
-
Brinster, R.L.1
-
25
-
-
84891791730
-
Gene Targeting in NOD mouse embryos using zinc-finger nucleases
-
Chen YG, et al. Gene Targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014;63:68–74.
-
(2014)
Diabetes
, vol.63
, pp. 68-74
-
-
Chen, Y.G.1
-
26
-
-
84862184780
-
Modeling disease mutations by gene targeting in one-cell mouse embryos
-
Meyer M, Ortiz O, Hrabe de Angelis M, Wurst W, Kuhn R. Modeling disease mutations by gene targeting in one-cell mouse embryos. Proc Natl Acad Sci U S A. 2012;109:9354–9.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 9354-9359
-
-
Meyer, M.1
Ortiz, O.2
Hrabe de Angelis, M.3
Wurst, W.4
Kuhn, R.5
-
27
-
-
83355168678
-
Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases
-
Osiak A, et al. Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases. PLoS One. 2011;6, e28911.
-
(2011)
Plos One
, vol.6
-
-
Osiak, A.1
-
28
-
-
0029967424
-
Sheep cloned by nuclear transfer from a cultured cell line
-
Campbell KH, McWhir J, Ritchie WA, Wilmut I. Sheep cloned by nuclear transfer from a cultured cell line. Nature. 1996;380:64–6.
-
(1996)
Nature
, vol.380
, pp. 64-66
-
-
Campbell, K.H.1
McWhir, J.2
Ritchie, W.A.3
Wilmut, I.4
-
30
-
-
79251529218
-
Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs
-
Whyte JJ, et al. Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs. Mol Reprod Dev. 2011;78:2.
-
(2011)
Mol Reprod Dev
, vol.78
, pp. 2
-
-
Whyte, J.J.1
-
31
-
-
79961079857
-
Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
-
Hauschild J, et al. Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci U S A. 2011;108:12013–7.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12013-12017
-
-
Hauschild, J.1
-
33
-
-
57049151425
-
Aggressive organ donor management protocol
-
DuBose J, Salim A. Aggressive organ donor management protocol. J Intensive Care Med. 2008;23:367–75.
-
(2008)
J Intensive Care Med
, vol.23
, pp. 367-375
-
-
Dubose, J.1
Salim, A.2
-
34
-
-
85142262352
-
-
Salim A, et al. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma. 2006;61:429–33; discussion 433-5.
-
Salim A, et al. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma. 2006;61:429–33; discussion 433-5.
-
-
-
-
35
-
-
80555150663
-
Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle
-
Yu S, et al. Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle. Cell Res. 2011;21:1638–40.
-
(2011)
Cell Res
, vol.21
, pp. 1638-1640
-
-
Yu, S.1
-
36
-
-
84886931066
-
Zinc-finger nickase-mediated insertion of the lysostaphin gene into the betacasein locus in cloned cows
-
Liu X, et al. Zinc-finger nickase-mediated insertion of the lysostaphin gene into the betacasein locus in cloned cows. Nat Commun. 2013;4:2565.
-
(2013)
Nat Commun
, vol.4
-
-
Liu, X.1
-
38
-
-
0000921589
-
Lysostaphin therapy in mice infected with Staphylococcus aureus
-
Schuhardt VT, Schindler CA. Lysostaphin therapy in mice infected with Staphylococcus aureus. J Bacteriol. 1964;88:815–6.
-
(1964)
J Bacteriol
, vol.88
, pp. 815-816
-
-
Schuhardt, V.T.1
Schindler, C.A.2
-
39
-
-
0034050151
-
Epidemiology of resistance to antibiotics. Links between animals and humans
-
van den Bogaard AE, Stobberingh EE. Epidemiology of resistance to antibiotics. Links between animals and humans. Int J Antimicrob Agents. 2000;14:327–35.
-
(2000)
Int J Antimicrob Agents
, vol.14
, pp. 327-335
-
-
van den Bogaard, A.E.1
Stobberingh, E.E.2
-
40
-
-
84890899357
-
Preserving antibiotics, rationally
-
Hollis A, Ahmed Z. Preserving antibiotics, rationally. N Engl J Med. 2013;369:2474–6.
-
(2013)
N Engl J Med
, vol.369
, pp. 2474-2476
-
-
Hollis, A.1
Ahmed, Z.2
-
41
-
-
0020444372
-
Social ramifications of control of microbial disease
-
McDermott W, Rogers DE. Social ramifications of control of microbial disease. Johns Hopkins Med J. 1982;151:302–12.
-
(1982)
Johns Hopkins Med J
, vol.151
, pp. 302-312
-
-
McDermott, W.1
Rogers, D.E.2
-
42
-
-
35948946526
-
Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery
-
Lombardo A, et al. Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery. Nat Biotechnol. 2007;25:1298–306.
-
(2007)
Nat Biotechnol
, vol.25
, pp. 1298-1306
-
-
Lombardo, A.1
-
43
-
-
84902315464
-
Targeted genome editing in human repopulating haematopoietic stem cells
-
Genovese P, et al. Targeted genome editing in human repopulating haematopoietic stem cells. Nature. 2014;510:235–40.
-
(2014)
Nature
, vol.510
, pp. 235-240
-
-
Genovese, P.1
-
44
-
-
84878561357
-
CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model
-
Watts KL, et al. CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model. Mol Ther. 2013;21:1270–8.
-
(2013)
Mol Ther
, vol.21
, pp. 1270-1278
-
-
Watts, K.L.1
-
45
-
-
77956519710
-
Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells
-
Boitano AE, et al. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science. 2010;329:1345–8.
-
(2010)
Science
, vol.329
, pp. 1345-1348
-
-
Boitano, A.E.1
-
46
-
-
27144518462
-
Dose-dependent effects of the notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells
-
Delaney C, Varnum-Finney B, Aoyama K, Brashem-Stein C, Bernstein ID. Dose-dependent effects of the notch ligand Delta1 on ex vivo differentiation and in vivo marrow repopulating ability of cord blood cells. Blood. 2005;106:2693–9.
-
(2005)
Blood
, vol.106
, pp. 2693-2699
-
-
Delaney, C.1
Varnum-Finney, B.2
Aoyama, K.3
Brashem-Stein, C.4
Bernstein, I.D.5
-
47
-
-
77956251480
-
Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis
-
Mohrin M, et al. Hematopoietic stem cell quiescence promotes error-prone DNA repair and mutagenesis. Cell Stem Cell. 2010;7:174–85.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 174-185
-
-
Mohrin, M.1
-
48
-
-
34250883337
-
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
-
North TE, et al. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 2007;447:1007–11.
-
(2007)
Nature
, vol.447
, pp. 1007-1011
-
-
North, T.E.1
-
49
-
-
79953885122
-
Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models
-
Goessling W, et al. Prostaglandin E2 enhances human cord blood stem cell xenotransplants and shows long-term safety in preclinical nonhuman primate transplant models. Cell Stem Cell. 2011;8:445–58.
-
(2011)
Cell Stem Cell
, vol.8
, pp. 445-458
-
-
Goessling, W.1
-
50
-
-
1842686860
-
Novel integrase-defective lentiviral episomal vectors for gene transfer
-
Vargas Jr J, Gusella GL, Najfeld V, Klotman ME, Cara A. Novel integrase-defective lentiviral episomal vectors for gene transfer. Hum Gene Ther. 2004;15:361–72.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 361-372
-
-
Vargas, J.1
Gusella, G.L.2
Najfeld, V.3
Klotman, M.E.4
Cara, A.5
-
51
-
-
33744468295
-
Transient gene expression by nonintegrating lentiviral vectors
-
Nightingale SJ, et al. Transient gene expression by nonintegrating lentiviral vectors. Mol Ther. 2006;13:1121–32.
-
(2006)
Mol Ther
, vol.13
, pp. 1121-1132
-
-
Nightingale, S.J.1
-
52
-
-
33644822908
-
Effective gene therapy with nonintegrating lentiviral vectors
-
Yanez-Munoz RJ, et al. Effective gene therapy with nonintegrating lentiviral vectors. Nat Med. 2006;12:348–53.
-
(2006)
Nat Med
, vol.12
, pp. 348-353
-
-
Yanez-Munoz, R.J.1
-
53
-
-
33845187432
-
Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo
-
Philippe S, et al. Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and in vivo. Proc Natl Acad Sci U S A. 2006;103:17684–9.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 17684-17689
-
-
Philippe, S.1
-
54
-
-
0030030041
-
Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection
-
Leavitt AD, Robles G, Alesandro N, Varmus HE. Human immunodeficiency virus type 1 integrase mutants retain in vitro integrase activity yet fail to integrate viral DNA efficiently during infection. J Virol. 1996;70:721–8.
-
(1996)
J Virol
, vol.70
, pp. 721-728
-
-
Leavitt, A.D.1
Robles, G.2
Alesandro, N.3
Varmus, H.E.4
-
55
-
-
80052766645
-
An unbiased genome-wide analysis of zinc-finger nuclease specificity
-
Gabriel R, et al. An unbiased genome-wide analysis of zinc-finger nuclease specificity. Nat Biotechnol. 2011;29:816–23.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 816-823
-
-
Gabriel, R.1
-
56
-
-
84878580410
-
TALEN-based gene correction for epidermolysis bullosa
-
Osborn MJ, et al. TALEN-based gene correction for epidermolysis bullosa. Mol Ther. 2013;21(6):1151–9.
-
(2013)
Mol Ther
, vol.21
, Issue.6
, pp. 1151-1159
-
-
Osborn, M.J.1
-
57
-
-
84878528467
-
Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases
-
Li L, et al. Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases. Mol Ther. 2013;21:1259–69.
-
(2013)
Mol Ther
, vol.21
, pp. 1259-1269
-
-
Li, L.1
-
58
-
-
84872775649
-
The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting
-
Rahman SH, et al. The nontoxic cell cycle modulator indirubin augments transduction of adeno-associated viral vectors and zinc-finger nuclease-mediated gene targeting. Hum Gene Ther. 2013;24:67–77.
-
(2013)
Hum Gene Ther
, vol.24
, pp. 67-77
-
-
Rahman, S.H.1
-
59
-
-
84928061468
-
Efficient genome editing in hematopoietic stem cells with helperdependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation
-
Saydaminova K, et al. Efficient genome editing in hematopoietic stem cells with helperdependent Ad5/35 vectors expressing site-specific endonucleases under microRNA regulation. Mol Ther Methods Clin Dev. 2015;1:14057.
-
(2015)
Mol Ther Methods Clin Dev
, vol.1
-
-
Saydaminova, K.1
-
60
-
-
77956839837
-
Chromosomal integration of adenoviral vector DNA in vivo
-
Stephen SL, et al. Chromosomal integration of adenoviral vector DNA in vivo. J Virol. 2010;84:9987–94.
-
(2010)
J Virol
, vol.84
, pp. 9987-9994
-
-
Stephen, S.L.1
-
61
-
-
0033056699
-
Frequency and stability of chromosomal integration of adenovirus vectors
-
Harui A, Suzuki S, Kochanek S, Mitani K. Frequency and stability of chromosomal integration of adenovirus vectors. J Virol. 1999;73:6141–6.
-
(1999)
J Virol
, vol.73
, pp. 6141-6146
-
-
Harui, A.1
Suzuki, S.2
Kochanek, S.3
Mitani, K.4
-
62
-
-
84886043841
-
Receptor-mediated delivery of engineered nucleases for genome modification
-
Chen Z, et al. Receptor-mediated delivery of engineered nucleases for genome modification. Nucleic Acids Res. 2013;41, e182.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e182
-
-
Chen, Z.1
-
63
-
-
78650735673
-
Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
-
Holt N, et al. Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo. Nat Biotechnol. 2010;28:839–47.
-
(2010)
Nat Biotechnol
, vol.28
, pp. 839-847
-
-
Holt, N.1
-
64
-
-
84890350615
-
Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice
-
Hofer U, et al. Pre-clinical modeling of CCR5 knockout in human hematopoietic stem cells by zinc finger nucleases using humanized mice. J Infect Dis. 2013;208 Suppl 2:S160–4.
-
(2013)
J Infect Dis
, vol.208
, pp. S160-S164
-
-
Hofer, U.1
-
65
-
-
79953117041
-
Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation
-
Allers K, et al. Evidence for the cure of HIV infection by CCR5Delta32/Delta32 stem cell transplantation. Blood. 2011;117:2791–9.
-
(2011)
Blood
, vol.117
, pp. 2791-2799
-
-
Allers, K.1
-
66
-
-
60549090253
-
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation
-
Hutter G, et al. Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation. N Engl J Med. 2009;360:692–8.
-
(2009)
N Engl J Med
, vol.360
, pp. 692-698
-
-
Hutter, G.1
-
67
-
-
34249992110
-
Prevalence of X4 tropic viruses in patients recently infected with HIV-1 and lack of association with transmission of drug resistance
-
de Mendoza C, et al. Prevalence of X4 tropic viruses in patients recently infected with HIV-1 and lack of association with transmission of drug resistance. J Antimicrob Chemother. 2007;59:698–704.
-
(2007)
J Antimicrob Chemother
, vol.59
, pp. 698-704
-
-
de Mendoza, C.1
-
68
-
-
85142247914
-
Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection
-
Didigu CA, et al. Simultaneous zinc-finger nuclease editing of the HIV coreceptors ccr5 and cxcr4 protects CD4+ T cells from HIV-1 infection. Blood. 2013.
-
Blood
, vol.2013
-
-
Didigu, C.A.1
-
69
-
-
70249114821
-
Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases
-
Hockemeyer D, et al. Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases. Nat Biotechnol. 2009;27:851–7.
-
(2009)
Nat Biotechnol
, vol.27
, pp. 851-857
-
-
Hockemeyer, D.1
-
70
-
-
77955157281
-
Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome
-
DeKelver RC, et al. Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genome. Genome Res. 2010;20:1133–42.
-
(2010)
Genome Res
, vol.20
, pp. 1133-1142
-
-
Dekelver, R.C.1
-
71
-
-
80053350622
-
Site-specific integration and tailoring of cassette design for sustainable gene transfer
-
Lombardo A, et al. Site-specific integration and tailoring of cassette design for sustainable gene transfer. Nat Methods. 2011;8:861–9.
-
(2011)
Nat Methods
, vol.8
, pp. 861-869
-
-
Lombardo, A.1
-
72
-
-
84871539019
-
Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging
-
Wang Y, et al. Genome editing of human embryonic stem cells and induced pluripotent stem cells with zinc finger nucleases for cellular imaging. Circ Res. 2012;111:1494–503.
-
(2012)
Circ Res
, vol.111
, pp. 1494-1503
-
-
Wang, Y.1
-
73
-
-
84655170273
-
Safe harbours for the integration of new DNA in the human genome
-
Sadelain M, Papapetrou EP, Bushman FD. Safe harbours for the integration of new DNA in the human genome. Nat Rev Cancer. 2012;12:51–8.
-
(2012)
Nat Rev Cancer
, vol.12
, pp. 51-58
-
-
Sadelain, M.1
Papapetrou, E.P.2
Bushman, F.D.3
-
74
-
-
67649170378
-
Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells
-
Zou J, et al. Gene targeting of a disease-related gene in human induced pluripotent stem and embryonic stem cells. Cell Stem Cell. 2009;5:97–110.
-
(2009)
Cell Stem Cell
, vol.5
, pp. 97-110
-
-
Zou, J.1
-
75
-
-
77952732489
-
Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations
-
Lengner CJ, et al. Derivation of pre-X inactivation human embryonic stem cells under physiological oxygen concentrations. Cell. 2010;141:872–83.
-
(2010)
Cell
, vol.141
, pp. 872-883
-
-
Lengner, C.J.1
-
76
-
-
78651108455
-
Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors
-
Narsinh KH, et al. Generation of adult human induced pluripotent stem cells using nonviral minicircle DNA vectors. Nat Protoc. 2011;6:78–88.
-
(2011)
Nat Protoc
, vol.6
, pp. 78-88
-
-
Narsinh, K.H.1
-
77
-
-
70350732790
-
A chemical platform for improved induction of human iPSCs
-
Lin T, et al. A chemical platform for improved induction of human iPSCs. Nat Methods. 2009;6:805–8.
-
(2009)
Nat Methods
, vol.6
, pp. 805-808
-
-
Lin, T.1
-
78
-
-
66049143859
-
Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins
-
Kim D, et al. Generation of human induced pluripotent stem cells by direct delivery of reprogramming proteins. Cell Stem Cell. 2009;4:472–6.
-
(2009)
Cell Stem Cell
, vol.4
, pp. 472-476
-
-
Kim, D.1
-
79
-
-
79960833952
-
Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
-
Soldner F, et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell. 2011;146:318–31.
-
(2011)
Cell
, vol.146
, pp. 318-331
-
-
Soldner, F.1
-
80
-
-
79952126043
-
Copy number variation and selection during reprogramming to pluripotency
-
Hussein SM, et al. Copy number variation and selection during reprogramming to pluripotency. Nature. 2011;471:58–62.
-
(2011)
Nature
, vol.471
, pp. 58-62
-
-
Hussein, S.M.1
-
81
-
-
82355183141
-
Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines
-
Dreyer AK, Cathomen T. Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines. Methods Mol Biol. 2012;813:145–56.
-
(2012)
Methods Mol Biol
, vol.813
, pp. 145-156
-
-
Dreyer, A.K.1
Cathomen, T.2
-
82
-
-
80054918967
-
In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases
-
Sebastiano V, et al. In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Stem Cells. 2011;29:1717–26.
-
(2011)
Stem Cells
, vol.29
, pp. 1717-1726
-
-
Sebastiano, V.1
-
83
-
-
80055069793
-
Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease
-
Zou J, Mali P, Huang X, Dowey SN, Cheng L. Site-specific gene correction of a point mutation in human iPS cells derived from an adult patient with sickle cell disease. Blood. 2011;118:4599–608.
-
(2011)
Blood
, vol.118
, pp. 4599-4608
-
-
Zou, J.1
Mali, P.2
Huang, X.3
Dowey, S.N.4
Cheng, L.5
-
85
-
-
80054987997
-
Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells
-
Yusa K, et al. Targeted gene correction of alpha1-antitrypsin deficiency in induced pluripotent stem cells. Nature. 2011;478:391–4.
-
(2011)
Nature
, vol.478
, pp. 391-394
-
-
Yusa, K.1
-
86
-
-
84930804885
-
Rescue of DNA-PK signaling and T-cell differentiation by targeted genome editing in a prkdc deficient iPSC disease model
-
Rahman SH, et al. Rescue of DNA-PK signaling and T-cell differentiation by targeted genome editing in a prkdc deficient iPSC disease model. PLoS Genet. 2015;11, e1005239.
-
(2015)
Plos Genet
, vol.11
-
-
Rahman, S.H.1
-
87
-
-
84881668417
-
Translating dosage compensation to trisomy 21
-
Jiang J, et al. Translating dosage compensation to trisomy 21. Nature. 2013;500:296–300.
-
(2013)
Nature
, vol.500
, pp. 296-300
-
-
Jiang, J.1
-
88
-
-
47349097567
-
Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification
-
Maeder ML, et al. Rapid “open-source” engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol Cell. 2008;31:294–301.
-
(2008)
Mol Cell
, vol.31
, pp. 294-301
-
-
Maeder, M.L.1
-
89
-
-
70349146995
-
Oligomerized pool engineering (OPEN): An ‘open-source’ protocol for making customized zinc-finger arrays
-
Maeder ML, Thibodeau-Beganny S, Sander JD, Voytas DF, Joung JK. Oligomerized pool engineering (OPEN): an ‘open-source’ protocol for making customized zinc-finger arrays. Nat Protoc. 2009;4:1471–501.
-
(2009)
Nat Protoc
, vol.4
, pp. 1471-1501
-
-
Maeder, M.L.1
Thibodeau-Beganny, S.2
Sander, J.D.3
Voytas, D.F.4
Joung, J.K.5
-
90
-
-
84866721599
-
Targeting G with TAL effectors: A comparison of activities of TALENs constructed with NN and NK repeat variable di-residues
-
Christian ML, et al. Targeting G with TAL effectors: a comparison of activities of TALENs constructed with NN and NK repeat variable di-residues. PLoS One. 2012;7, e45383.
-
(2012)
Plos One
, vol.7
-
-
Christian, M.L.1
-
91
-
-
79960064013
-
Efficient design and assembly of custom TALEN and other TAL effectorbased constructs for DNA targeting
-
Cermak T, et al. Efficient design and assembly of custom TALEN and other TAL effectorbased constructs for DNA targeting. Nucleic Acids Res. 2011;39, e82.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. e82
-
-
Cermak, T.1
-
92
-
-
72149090954
-
A simple cipher governs DNA recognition by TAL effectors
-
Moscou MJ, Bogdanove AJ. A simple cipher governs DNA recognition by TAL effectors. Science. 2009;326:1501.
-
(2009)
Science
, vol.326
, pp. 1501
-
-
Moscou, M.J.1
Bogdanove, A.J.2
-
93
-
-
79961196358
-
Knockout rats generated by embryo microinjection of TALENs
-
Tesson L, et al. Knockout rats generated by embryo microinjection of TALENs. Nat Biotechnol. 2011;29:695–6.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 695-696
-
-
Tesson, L.1
-
94
-
-
84874322004
-
Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes
-
Mashimo T, et al. Efficient gene targeting by TAL effector nucleases coinjected with exonucleases in zygotes. Sci Rep. 2013;3:1253.
-
(2013)
Sci Rep
, vol.3
-
-
Mashimo, T.1
-
95
-
-
84867061435
-
Coupling endonucleases with DNA end-processing enzymes to drive gene disruption
-
Certo MT, et al. Coupling endonucleases with DNA end-processing enzymes to drive gene disruption. Nat Methods. 2012;9:973–5.
-
(2012)
Nat Methods
, vol.9
, pp. 973-975
-
-
Certo, M.T.1
-
96
-
-
84872194963
-
Knockout mice created by TALEN-mediated gene targeting
-
Sung YH, et al. Knockout mice created by TALEN-mediated gene targeting. Nat Biotechnol. 2013;31:23–4.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 23-24
-
-
Sung, Y.H.1
-
97
-
-
84875531751
-
Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes
-
Davies B, et al. Site specific mutation of the Zic2 locus by microinjection of TALEN mRNA in mouse CD1, C3H and C57BL/6J oocytes. PLoS One. 2013;8, e60216.
-
(2013)
Plos One
, vol.8
-
-
Davies, B.1
-
98
-
-
0031694448
-
Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired
-
Brown SA, et al. Holoprosencephaly due to mutations in ZIC2, a homologue of Drosophila odd-paired. Nat Genet. 1998;20:180–3.
-
(1998)
Nat Genet
, vol.20
, pp. 180-183
-
-
Brown, S.A.1
-
99
-
-
84878826580
-
High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases
-
Qiu Z, et al. High-efficiency and heritable gene targeting in mouse by transcription activator-like effector nucleases. Nucleic Acids Res. 2013;41, e120.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e120
-
-
Qiu, Z.1
-
100
-
-
84889099952
-
Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis
-
Kahle M, et al. Phenotypic comparison of common mouse strains developing high-fat diet-induced hepatosteatosis. Mol Metab. 2013;2:435–46.
-
(2013)
Mol Metab
, vol.2
, pp. 435-446
-
-
Kahle, M.1
-
101
-
-
84880285567
-
TALEN-mediated editing of the mouse Y chromosome
-
Wang H, et al. TALEN-mediated editing of the mouse Y chromosome. Nat Biotechnol. 2013;31:530–2.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 530-532
-
-
Wang, H.1
-
102
-
-
84885703560
-
Targeted gene deletion of miRNAs in mice by TALEN system
-
Takada S, et al. Targeted gene deletion of miRNAs in mice by TALEN system. PLoS One. 2013;8, e76004.
-
(2013)
Plos One
, vol.8
-
-
Takada, S.1
-
103
-
-
84874628805
-
Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides
-
Wefers B, et al. Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides. Proc Natl Acad Sci U S A. 2013;110:3782–7.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3782-3787
-
-
Wefers, B.1
-
104
-
-
84887061001
-
Highly efficient targeted mutagenesis in mice using TALENs
-
Panda SK, et al. Highly efficient targeted mutagenesis in mice using TALENs. Genetics. 2013;195:703–13.
-
(2013)
Genetics
, vol.195
, pp. 703-713
-
-
Panda, S.K.1
-
105
-
-
84892689751
-
Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair
-
Low BE, et al. Correction of Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair. Invest Ophthalmol Vis Sci. 2013.
-
Invest Ophthalmol Vis Sci
, vol.2013
-
-
Low, B.E.1
-
106
-
-
77955126358
-
Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology
-
Orlando SJ, et al. Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology. Nucleic Acids Res. 2010;38, e152.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. e152
-
-
Orlando, S.J.1
-
107
-
-
84867911474
-
Efficient TALEN-mediated gene knockout in livestock
-
Carlson DF, et al. Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci U S A. 2012;109:17382–7.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 17382-17387
-
-
Carlson, D.F.1
-
108
-
-
37549030199
-
Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin
-
Hanna J, et al. Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science. 2007;318:1920–3.
-
(2007)
Science
, vol.318
, pp. 1920-1923
-
-
Hanna, J.1
-
109
-
-
84885358161
-
Efficient nonmeiotic allele introgression in livestock using custom endonucleases
-
Tan W, et al. Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A. 2013;110:16526–31.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16526-16531
-
-
Tan, W.1
-
110
-
-
84892934410
-
Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs
-
Xin J, et al. Highly efficient generation of GGTA1 biallelic knockout inbred mini-pigs with TALENs. PLoS One. 2013;8, e84250.
-
(2013)
Plos One
, vol.8
-
-
Xin, J.1
-
111
-
-
78951479577
-
Targeting DNA double-strand breaks with TAL effector nucleases
-
Christian M, et al. Targeting DNA double-strand breaks with TAL effector nucleases. Genetics. 2010;186:757–61.
-
(2010)
Genetics
, vol.186
, pp. 757-761
-
-
Christian, M.1
-
112
-
-
79551685675
-
A TALE nuclease architecture for efficient genome editing
-
Miller JC, et al. A TALE nuclease architecture for efficient genome editing. Nat Biotechnol. 2011;29:143–8.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 143-148
-
-
Miller, J.C.1
-
113
-
-
80053039555
-
A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity
-
Mussolino C, et al. A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity. Nucleic Acids Res. 2011;39:9283–93.
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 9283-9293
-
-
Mussolino, C.1
-
114
-
-
84896142186
-
TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys
-
Liu H, et al. TALEN-mediated gene mutagenesis in rhesus and cynomolgus monkeys. Cell Stem Cell. 2014;14:323–8.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 323-328
-
-
Liu, H.1
-
115
-
-
79960836456
-
Genetic engineering of human pluripotent cells using TALE nucleases
-
Hockemeyer D, et al. Genetic engineering of human pluripotent cells using TALE nucleases. Nat Biotechnol. 2011;29:731–4.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 731-734
-
-
Hockemeyer, D.1
-
116
-
-
84873733109
-
A TALEN genome-editing system for generating human stem cell-based disease models
-
Ding Q, et al. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 2013;12:238–51.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 238-251
-
-
Ding, Q.1
-
117
-
-
80055087787
-
An activating mutation of AKT2 and human hypoglycemia
-
Hussain K, et al. An activating mutation of AKT2 and human hypoglycemia. Science. 2011;334:474.
-
(2011)
Science
, vol.334
, pp. 474
-
-
Hussain, K.1
-
118
-
-
77955499945
-
From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus
-
Musunuru K, et al. From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus. Nature. 2010;466:714–9.
-
(2010)
Nature
, vol.466
, pp. 714-719
-
-
Musunuru, K.1
-
119
-
-
85142289951
-
DICE, an efficient system for iterative genomic editing in human pluripotent stem cells
-
Zhu F, et al. DICE, an efficient system for iterative genomic editing in human pluripotent stem cells. Nucleic Acids Res. 2013.
-
(2013)
Nucleic Acids Res
-
-
Zhu, F.1
-
120
-
-
84885939240
-
Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells
-
Zhu H, et al. Baculoviral transduction facilitates TALEN-mediated targeted transgene integration and Cre/LoxP cassette exchange in human-induced pluripotent stem cells. Nucleic Acids Res. 2013;41, e180.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e180
-
-
Zhu, H.1
-
121
-
-
84883853721
-
Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repressor and TALEN
-
Zhang Z, et al. Dissecting the roles of miR-302/367 cluster in cellular reprogramming using TALE-based repressor and TALEN. Stem Cell Reports. 2013;1:218–25.
-
(2013)
Stem Cell Reports
, vol.1
, pp. 218-225
-
-
Zhang, Z.1
-
122
-
-
84863201964
-
Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
-
Bultmann S, et al. Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers. Nucleic Acids Res. 2012;40:5368–77.
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 5368-5377
-
-
Bultmann, S.1
-
123
-
-
84890048526
-
Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins
-
Maeder ML, et al. Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins. Nat Biotechnol. 2013;31:1137–42.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 1137-1142
-
-
Maeder, M.L.1
-
124
-
-
84879116702
-
Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells
-
Choi SM, et al. Efficient drug screening and gene correction for treating liver disease using patient-specific stem cells. Hepatology. 2013;57:2458–68.
-
(2013)
Hepatology
, vol.57
, pp. 2458-2468
-
-
Choi, S.M.1
-
125
-
-
84897080609
-
Seamless correction of the sickle cell disease mutation of the HBB gene in human induced pluripotent stem cells using TALENs
-
Sun N, Zhao H. Seamless correction of the sickle cell disease mutation of the HBB gene in human induced pluripotent stem cells using TALENs. Biotechnol Bioeng. 2013.
-
(2013)
Biotechnol Bioeng
-
-
Sun, N.1
Zhao, H.2
-
126
-
-
79960064013
-
Efficient design and assembly of custom TALEN and other TAL effectorbased constructs for DNA targeting
-
Cermak T, et al. Efficient design and assembly of custom TALEN and other TAL effectorbased constructs for DNA targeting. Nucleic Acids Res. 2011;39(17):7879.
-
(2011)
Nucleic Acids Res
, vol.39
, Issue.17
, pp. 7879
-
-
Cermak, T.1
-
127
-
-
84876389220
-
Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells
-
Holkers M, et al. Differential integrity of TALE nuclease genes following adenoviral and lentiviral vector gene transfer into human cells. Nucleic Acids Res. 2013;41, e63.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e63
-
-
Holkers, M.1
-
128
-
-
84865070369
-
A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity
-
Jinek M, et al. A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity. Science. 2012;337:816–21.
-
(2012)
Science
, vol.337
, pp. 816-821
-
-
Jinek, M.1
-
129
-
-
84873734105
-
RNA-guided human genome engineering via Cas9
-
Mali P, et al. RNA-guided human genome engineering via Cas9. Science. 2013;339(6121): 823–6.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 823-826
-
-
Mali, P.1
-
130
-
-
84873729095
-
Multiplex genome engineering using CRISPR/Cas systems
-
Cong L, et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013; 339(6121):819–23.
-
(2013)
Science
, vol.339
, Issue.6121
, pp. 819-823
-
-
Cong, L.1
-
131
-
-
84889589440
-
Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA
-
Mashiko D, et al. Generation of mutant mice by pronuclear injection of circular plasmid expressing Cas9 and single guided RNA. Sci Rep. 2013;3:3355.
-
(2013)
Sci Rep
, vol.3
-
-
Mashiko, D.1
-
132
-
-
84883819602
-
Heritable gene targeting in the mouse and rat using a CRISPR-Cas system
-
Li D, et al. Heritable gene targeting in the mouse and rat using a CRISPR-Cas system. Nat Biotechnol. 2013;31:681–3.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 681-683
-
-
Li, D.1
-
133
-
-
84890014631
-
Efficient generation of large-scale genomemodified mice using gRNA and CAS9 endonuclease
-
Fujii W, Kawasaki K, Sugiura K, Naito K. Efficient generation of large-scale genomemodified mice using gRNA and CAS9 endonuclease. Nucleic Acids Res. 2013;41, e187.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e187
-
-
Fujii, W.1
Kawasaki, K.2
Sugiura, K.3
Naito, K.4
-
134
-
-
84889855901
-
One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering
-
Zhou J, et al. One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering. Int J Biochem Cell Biol. 2014;46:49–55.
-
(2014)
Int J Biochem Cell Biol
, vol.46
, pp. 49-55
-
-
Zhou, J.1
-
135
-
-
84877707375
-
One-step generation of mice carrying mutations in multiple genes by CRISPR/ Cas-mediated genome engineering
-
Wang H, et al. One-step generation of mice carrying mutations in multiple genes by CRISPR/ Cas-mediated genome engineering. Cell. 2013;153:910–8.
-
(2013)
Cell
, vol.153
, pp. 910-918
-
-
Wang, H.1
-
136
-
-
84884289608
-
One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering
-
Yang H, et al. One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering. Cell. 2013;154:1370–9.
-
(2013)
Cell
, vol.154
, pp. 1370-1379
-
-
Yang, H.1
-
137
-
-
84898665052
-
Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library
-
Koike-Yusa H, Li Y, Tan E-P, Velasco-Herrera MDC, Yusa K. Genome-wide recessive genetic screening in mammalian cells with a lentiviral CRISPR-guide RNA library. Nat Biotechnol. 2014;32(3):267–73.
-
(2014)
Nat Biotechnol
, vol.32
, Issue.3
, pp. 267-273
-
-
Koike-Yusa, H.1
Li, Y.2
Tan, E.-P.3
Velasco-Herrera, M.D.C.4
Yusa, K.5
-
138
-
-
84891745242
-
Generating rats with conditional alleles using CRISPR/Cas9
-
Ma Y, et al. Generating rats with conditional alleles using CRISPR/Cas9. Cell Res. 2014;24:122–5.
-
(2014)
Cell Res
, vol.24
, pp. 122-125
-
-
Ma, Y.1
-
139
-
-
84896274627
-
Genetic modification and screening in Rat using haploid embryonic stem cells
-
Li W, et al. Genetic modification and screening in Rat using haploid embryonic stem cells. Cell Stem Cell. 2013.
-
Cell Stem Cell
, vol.2013
-
-
Li, W.1
-
140
-
-
0036250938
-
Rat genetics: Attaching physiology and pharmacology to the genome
-
Jacob HJ, Kwitek AE. Rat genetics: attaching physiology and pharmacology to the genome. Nat Rev Genet. 2002;3:33–42.
-
(2002)
Nat Rev Genet
, vol.3
, pp. 33-42
-
-
Jacob, H.J.1
Kwitek, A.E.2
-
141
-
-
84922258547
-
One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system
-
Wan H, et al. One-step generation of p53 gene biallelic mutant Cynomolgus monkey via the CRISPR/Cas system. Cell Res. 2015;25:258–61.
-
(2015)
Cell Res
, vol.25
, pp. 258-261
-
-
Wan, H.1
-
142
-
-
84892765883
-
Genome-scale CRISPR-Cas9 knockout screening in human cells
-
Shalem O, et al. Genome-scale CRISPR-Cas9 knockout screening in human cells. Science. 2014;343:84–7.
-
(2014)
Science
, vol.343
, pp. 84-87
-
-
Shalem, O.1
-
143
-
-
84884663630
-
Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis
-
Hou Z, et al. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A. 2013;110:15644–9.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 15644-15649
-
-
Hou, Z.1
-
144
-
-
84887104139
-
Orthogonal Cas9 proteins for RNA-guided gene regulation and editing
-
Esvelt KM, et al. Orthogonal Cas9 proteins for RNA-guided gene regulation and editing. Nat Methods. 2013;10:1116–21.
-
(2013)
Nat Methods
, vol.10
, pp. 1116-1121
-
-
Esvelt, K.M.1
-
145
-
-
79955611823
-
Chemically defined conditions for human iPSC derivation and culture
-
Chen G, et al. Chemically defined conditions for human iPSC derivation and culture. Nat Methods. 2011;8:424–9.
-
(2011)
Nat Methods
, vol.8
, pp. 424-429
-
-
Chen, G.1
-
146
-
-
84927514894
-
In vivo genome editing using Staphylococcus aureus Cas9
-
Ran FA, et al. In vivo genome editing using Staphylococcus aureus Cas9. Nature. 2015;520:186–91.
-
(2015)
Nature
, vol.520
, pp. 186-191
-
-
Ran, F.A.1
-
147
-
-
84937908208
-
Engineered CRISPR-Cas9 nucleases with altered PAM specificities
-
Kleinstiver BP, et al. Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 2015.
-
(2015)
Nature
-
-
Kleinstiver, B.P.1
-
148
-
-
84890033064
-
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients
-
Schwank G, et al. Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients. Cell Stem Cell. 2013;13:653–8.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 653-658
-
-
Schwank, G.1
-
149
-
-
84890050551
-
Correction of a genetic disease in mouse via use of CRISPR-Cas9
-
Wu Y, et al. Correction of a genetic disease in mouse via use of CRISPR-Cas9. Cell Stem Cell. 2013;13:659–62.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 659-662
-
-
Wu, Y.1
-
150
-
-
84946727639
-
A doxycycline-inducible system for genetic correction of iPSC disease models
-
Sim X, Cardenas-Diaz FL, French DL, Gadue P. A doxycycline-inducible system for genetic correction of iPSC disease models. Methods Mol Biol. 2016;1353:13–23.
-
(2016)
Methods Mol Biol
, vol.1353
, pp. 13-23
-
-
Sim, X.1
Cardenas-Diaz, F.L.2
French, D.L.3
Gadue, P.4
-
151
-
-
84934285785
-
Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system
-
Song B, et al. Improved hematopoietic differentiation efficiency of gene-corrected beta-thalassemia induced pluripotent stem cells by CRISPR/Cas9 system. Stem Cells Dev. 2015;24:1053–65.
-
(2015)
Stem Cells Dev
, vol.24
, pp. 1053-1065
-
-
Song, B.1
-
152
-
-
84920853711
-
Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9
-
Li HL, et al. Precise correction of the dystrophin gene in duchenne muscular dystrophy patient induced pluripotent stem cells by TALEN and CRISPR-Cas9. Stem Cell Reports. 2015;4:143–54.
-
(2015)
Stem Cell Reports
, vol.4
, pp. 143-154
-
-
Li, H.L.1
-
153
-
-
84907219050
-
Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac
-
Xie F, et al. Seamless gene correction of beta-thalassemia mutations in patient-specific iPSCs using CRISPR/Cas9 and piggyBac. Genome Res. 2014;24:1526–33.
-
(2014)
Genome Res
, vol.24
, pp. 1526-1533
-
-
Xie, F.1
-
154
-
-
84942519810
-
CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
-
e3
-
Flynn R, et al. CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells. Exp Hematol. 2015;43(10):838–48.e3.
-
(2015)
Exp Hematol
, vol.43
, Issue.10
, pp. 838-848
-
-
Flynn, R.1
-
155
-
-
84928577551
-
Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation
-
Huang X, et al. Production of gene-corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation. Stem Cells. 2015;33:1470–9.
-
(2015)
Stem Cells
, vol.33
, pp. 1470-1479
-
-
Huang, X.1
-
156
-
-
84941172775
-
Generation of isogenic human iPS cell line precisely corrected by genome editing using the CRISPR/Cas9 system
-
Grobarczyk B, Franco B, Hanon K, Malgrange B. Generation of isogenic human iPS cell line precisely corrected by genome editing using the CRISPR/Cas9 system. Stem Cell Rev. 2015;11(5):774–87.
-
(2015)
Stem Cell Rev
, vol.11
, Issue.5
, pp. 774-787
-
-
Grobarczyk, B.1
Franco, B.2
Hanon, K.3
Malgrange, B.4
-
157
-
-
84895528015
-
Isolation of single-base genome-edited human iPS cells without antibiotic selection
-
Miyaoka Y, et al. Isolation of single-base genome-edited human iPS cells without antibiotic selection. Nat Methods. 2014;11:291–3.
-
(2014)
Nat Methods
, vol.11
, pp. 291-293
-
-
Miyaoka, Y.1
-
158
-
-
84866859751
-
Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria
-
Gasiunas G, Barrangou R, Horvath P, Siksnys V. Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria. Proc Natl Acad Sci U S A. 2012;109(39):E2579–86.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, Issue.39
, pp. E2579-E2586
-
-
Gasiunas, G.1
Barrangou, R.2
Horvath, P.3
Siksnys, V.4
-
159
-
-
84896267457
-
Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair
-
Davis L, Maizels N. Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair. Proc Natl Acad Sci U S A. 2014;111:E924–32.
-
(2014)
Proc Natl Acad Sci U S A
, vol.111
, pp. E924-E932
-
-
Davis, L.1
Maizels, N.2
-
160
-
-
84923185262
-
Fanconi anemia gene editing by the CRISPR/Cas9 system
-
Osborn M, Gabriel R, Webber BR, DeFeo AP, McElroy AN, Jarjour J, Starker CG, Wagner JE, Joung JK, Voytas DF, von Kalle C, Schmidt M, Blazar BR, Tolar J. Fanconi anemia gene editing by the CRISPR/Cas9 system. Hum Gene Ther. 2014;26(2):114–26.
-
(2014)
Hum Gene Ther
, vol.26
, Issue.2
, pp. 114-126
-
-
Osborn, M.1
Gabriel, R.2
Webber, B.R.3
Defeo, A.P.4
McElroy, A.N.5
Jarjour, J.6
Starker, C.G.7
Wagner, J.E.8
Joung, J.K.9
Voytas, D.F.10
von Kalle, C.11
Schmidt, M.12
Blazar, B.R.13
Tolar, J.14
-
161
-
-
84902210542
-
Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification
-
Guilinger JP, Thompson DB, Liu DR. Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification. Nat Biotechnol. 2014;32:577–82.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 577-582
-
-
Guilinger, J.P.1
Thompson, D.B.2
Liu, D.R.3
-
162
-
-
84937575600
-
Dimeric CRISPR RNA-guided FokI-dCas9 nucleases (RFNs) directed by truncated gRNAs for highly specific genome editing
-
Wyvekens N, Topkar VV, Khayter C, Joung JK, Tsai SQ. Dimeric CRISPR RNA-guided FokI-dCas9 nucleases (RFNs) directed by truncated gRNAs for highly specific genome editing. Hum Gene Ther. 2015.
-
(2015)
Hum Gene Ther
-
-
Wyvekens, N.1
Topkar, V.V.2
Khayter, C.3
Joung, J.K.4
Tsai, S.Q.5
-
163
-
-
84902204289
-
Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing
-
Tsai SQ, et al. Dimeric CRISPR RNA-guided FokI nucleases for highly specific genome editing. Nat Biotechnol. 2014;32:569–76.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 569-576
-
-
Tsai, S.Q.1
-
164
-
-
84885180675
-
Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system
-
Cheng AW, et al. Multiplexed activation of endogenous genes by CRISPR-on, an RNA-guided transcriptional activator system. Cell Res. 2013;23:1163–71.
-
(2013)
Cell Res
, vol.23
, pp. 1163-1171
-
-
Cheng, A.W.1
-
165
-
-
84890460786
-
Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
-
Kearns NA, et al. Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development. 2014;141:219–23.
-
(2014)
Development
, vol.141
, pp. 219-223
-
-
Kearns, N.A.1
-
166
-
-
84926521955
-
Highly efficient Cas9-mediated transcriptional programming
-
Chavez A, et al. Highly efficient Cas9-mediated transcriptional programming. Nat Methods. 2015;12:326–8.
-
(2015)
Nat Methods
, vol.12
, pp. 326-328
-
-
Chavez, A.1
-
167
-
-
84923096541
-
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
-
Konermann S, et al. Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex. Nature. 2015;517:583–8.
-
(2015)
Nature
, vol.517
, pp. 583-588
-
-
Konermann, S.1
-
168
-
-
84929135130
-
Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers
-
Hilton IB, et al. Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. Nat Biotechnol. 2015;33:510–7.
-
(2015)
Nat Biotechnol
, vol.33
, pp. 510-517
-
-
Hilton, I.B.1
-
169
-
-
83255189758
-
Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage
-
Amps K, et al. Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage. Nat Biotechnol. 2011;29:1132–44.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 1132-1144
-
-
Amps, K.1
-
170
-
-
84859503582
-
High prevalence of evolutionarily conserved and speciesspecific genomic aberrations in mouse pluripotent stem cells
-
Ben-David U, Benvenisty N. High prevalence of evolutionarily conserved and speciesspecific genomic aberrations in mouse pluripotent stem cells. Stem Cells. 2012;30:612–22.
-
(2012)
Stem Cells
, vol.30
, pp. 612-622
-
-
Ben-David, U.1
Benvenisty, N.2
-
171
-
-
77957334627
-
Identification and classification of chromosomal aberrations in human induced pluripotent stem cells
-
Mayshar Y, et al. Identification and classification of chromosomal aberrations in human induced pluripotent stem cells. Cell Stem Cell. 2010;7:521–31.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 521-531
-
-
Mayshar, Y.1
-
172
-
-
79957651366
-
Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells
-
Mayshar Y, Yanuka O, Benvenisty N. Teratogen screening using transcriptome profiling of differentiating human embryonic stem cells. J Cell Mol Med. 2011;15:1393–401.
-
(2011)
J Cell Mol Med
, vol.15
, pp. 1393-1401
-
-
Mayshar, Y.1
Yanuka, O.2
Benvenisty, N.3
-
173
-
-
84875670647
-
Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming
-
Ruiz S, et al. Analysis of protein-coding mutations in hiPSCs and their possible role during somatic cell reprogramming. Nat Commun. 2013;4:1382.
-
(2013)
Nat Commun
, vol.4
-
-
Ruiz, S.1
-
174
-
-
84872018370
-
Embryonic stem cell and induced pluripotent stem cell: An epigenetic perspective
-
Liang G, Zhang Y. Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective. Cell Res. 2013;23:49–69.
-
(2013)
Cell Res
, vol.23
, pp. 49-69
-
-
Liang, G.1
Zhang, Y.2
-
175
-
-
77956222202
-
Female human iPSCs retain an inactive X chromosome
-
Tchieu J, et al. Female human iPSCs retain an inactive X chromosome. Cell Stem Cell. 2010;7:329–42.
-
(2010)
Cell Stem Cell
, vol.7
, pp. 329-342
-
-
Tchieu, J.1
-
176
-
-
84860640679
-
Erosion of dosage compensation impacts human iPSC disease modeling
-
Mekhoubad S, et al. Erosion of dosage compensation impacts human iPSC disease modeling. Cell Stem Cell. 2012;10:595–609.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 595-609
-
-
Mekhoubad, S.1
-
177
-
-
84863608994
-
Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes
-
Anguera MC, et al. Molecular signatures of human induced pluripotent stem cells highlight sex differences and cancer genes. Cell Stem Cell. 2012;11:75–90.
-
(2012)
Cell Stem Cell
, vol.11
, pp. 75-90
-
-
Anguera, M.C.1
-
178
-
-
79952264847
-
Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells
-
Lister R, et al. Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells. Nature. 2011;471:68–73.
-
(2011)
Nature
, vol.471
, pp. 68-73
-
-
Lister, R.1
-
179
-
-
84867035018
-
Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells
-
Ruiz S, et al. Identification of a specific reprogramming-associated epigenetic signature in human induced pluripotent stem cells. Proc Natl Acad Sci U S A. 2012;109:16196–201.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 16196-16201
-
-
Ruiz, S.1
-
180
-
-
84883386827
-
Inhibition of pluripotent stem cell-derived teratoma formation by small molecules
-
Lee MO, et al. Inhibition of pluripotent stem cell-derived teratoma formation by small molecules. Proc Natl Acad Sci U S A. 2013;110:E3281–90.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. E3281-E3290
-
-
Lee, M.O.1
-
181
-
-
80052749542
-
An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells
-
Tang C, et al. An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol. 2011;29:829–34.
-
(2011)
Nat Biotechnol
, vol.29
, pp. 829-834
-
-
Tang, C.1
-
182
-
-
80053005674
-
Immunogenicity of induced pluripotent stem cells
-
Okita K, Nagata N, Yamanaka S. Immunogenicity of induced pluripotent stem cells. Circ Res. 2011;109:720–1.
-
(2011)
Circ Res
, vol.109
, pp. 720-721
-
-
Okita, K.1
Nagata, N.2
Yamanaka, S.3
-
183
-
-
80052293623
-
Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection
-
Pattanayak V, Ramirez CL, Joung JK, Liu DR. Revealing off-target cleavage specificities of zinc-finger nucleases by in vitro selection. Nat Methods. 2011;8(9):765–70.
-
(2011)
Nat Methods
, vol.8
, Issue.9
, pp. 765-770
-
-
Pattanayak, V.1
Ramirez, C.L.2
Joung, J.K.3
Liu, D.R.4
-
184
-
-
84993877395
-
Zinc fingers hit off target
-
Cheng L, Blazar B, High K, Porteus M. Zinc fingers hit off target. Nat Med. 2011;17(10):1192–3.
-
(2011)
Nat Med
, vol.17
, Issue.10
, pp. 1192-1193
-
-
Cheng, L.1
Blazar, B.2
High, K.3
Porteus, M.4
-
185
-
-
84885979507
-
In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites
-
Sander JD, et al. In silico abstraction of zinc finger nuclease cleavage profiles reveals an expanded landscape of off-target sites. Nucleic Acids Res. 2013;41, e181.
-
(2013)
Nucleic Acids Res
, vol.41
, pp. e181
-
-
Sander, J.D.1
-
186
-
-
84884288934
-
Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity
-
Ran FA, et al. Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity. Cell. 2013;154:1380–9.
-
(2013)
Cell
, vol.154
, pp. 1380-1389
-
-
Ran, F.A.1
-
187
-
-
84887010498
-
Genome engineering using the CRISPR-Cas9 system
-
Ran FA, et al. Genome engineering using the CRISPR-Cas9 system. Nat Protoc. 2013;8:2281–308.
-
(2013)
Nat Protoc
, vol.8
, pp. 2281-2308
-
-
Ran, F.A.1
-
188
-
-
77955220225
-
Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing
-
Paruzynski A, et al. Genome-wide high-throughput integrome analyses by nrLAM-PCR and next-generation sequencing. Nat Protoc. 2010;5(8):1379–95.
-
(2010)
Nat Protoc
, vol.5
, Issue.8
, pp. 1379-1395
-
-
Paruzynski, A.1
-
189
-
-
84923266604
-
GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases
-
Tsai SQ, et al. GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases. Nat Biotechnol. 2015;33:187–97.
-
(2015)
Nat Biotechnol
, vol.33
, pp. 187-197
-
-
Tsai, S.Q.1
-
190
-
-
85142219147
-
-
Kim D, et al. Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat Methods. 2015;12:237–43, 1 p following 243.
-
Kim D, et al. Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells. Nat Methods. 2015;12:237–43, 1 p following 243.
-
-
-
-
191
-
-
84923275611
-
Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases
-
Frock RL, et al. Genome-wide detection of DNA double-stranded breaks induced by engineered nucleases. Nat Biotechnol. 2015;33:179–86.
-
(2015)
Nat Biotechnol
, vol.33
, pp. 179-186
-
-
Frock, R.L.1
-
192
-
-
84875754465
-
Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing
-
Crosetto N, et al. Nucleotide-resolution DNA double-strand break mapping by next-generation sequencing. Nat Methods. 2013;10:361–5.
-
(2013)
Nat Methods
, vol.10
, pp. 361-365
-
-
Crosetto, N.1
-
193
-
-
84895487305
-
Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV
-
Tebas P, et al. Gene editing of CCR5 in autologous CD4 T cells of persons infected with HIV. N Engl J Med. 2014;370:901–10.
-
(2014)
N Engl J Med
, vol.370
, pp. 901-910
-
-
Tebas, P.1
-
194
-
-
78650912707
-
Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures
-
Doyon Y, et al. Enhancing zinc-finger-nuclease activity with improved obligate heterodimeric architectures. Nat Methods. 2011;8(1):74–9.
-
(2011)
Nat Methods
, vol.8
, Issue.1
, pp. 74-79
-
-
Doyon, Y.1
-
195
-
-
84896929630
-
Improving CRISPR-Cas nuclease specificity using truncated guide RNAs
-
Fu Y, Sander JD, Reyon D, Cascio VM, Joung JK. Improving CRISPR-Cas nuclease specificity using truncated guide RNAs. Nat Biotechnol. 2014;32:279–84.
-
(2014)
Nat Biotechnol
, vol.32
, pp. 279-284
-
-
Fu, Y.1
Sander, J.D.2
Reyon, D.3
Cascio, V.M.4
Joung, J.K.5
-
196
-
-
84933046479
-
Ethics of iPSC-based clinical research for age-related macular degeneration: Patient-centered risk-benefit analysis
-
Nakano-Okuno M, Borah BR, Nakano I. Ethics of iPSC-based clinical research for age-related macular degeneration: patient-centered risk-benefit analysis. Stem Cell Rev. 2014; 10:743–52.
-
(2014)
Stem Cell Rev
, vol.10
, pp. 743-752
-
-
Nakano-Okuno, M.1
Borah, B.R.2
Nakano, I.3
-
197
-
-
78650775954
-
The $1,000 genome, the $100,000 analysis?
-
Mardis ER. The $1,000 genome, the $100,000 analysis? Genome Med. 2010;2:84.
-
(2010)
Genome Med
, vol.2
, pp. 84
-
-
Mardis, E.R.1
-
198
-
-
84928775204
-
Don’t edit the human germ line
-
Lanphier E, Urnov F, Haecker SE, Werner M, Smolenski J. Don’t edit the human germ line. Nature. 2015;519:410–1.
-
(2015)
Nature
, vol.519
, pp. 410-411
-
-
Lanphier, E.1
Urnov, F.2
Haecker, S.E.3
Werner, M.4
Smolenski, J.5
-
199
-
-
84930618439
-
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes
-
Liang P, et al. CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes. Protein Cell. 2015;6:363–72.
-
(2015)
Protein Cell
, vol.6
, pp. 363-372
-
-
Liang, P.1
|