Dimeric CRISPR RNA-Guided FokI-dCas9 Nucleases Directed by Truncated gRNAs for Highly Specific Genome Editing

Human Gene Therapy

Volumn 26, Issue 7, 2015, Pages 425-431

  Wyvekens, Nicolas ^a   Topkar, Ved V ^a   Khayter, Cyd ^a   Joung, J Keith ^a,b   Tsai, Shengdar Q ^a,b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED 9 PROTEIN; CRISPR ASSOCIATED PROTEIN; FOKI ENZYME; GUIDE RNA; MONOMER; NUCLEASE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 ENDONUCLEASE STREPTOCOCCUS PYOGENES; DEOXYRIBONUCLEASE; DNA MODIFICATION METHYLASE FOKI; ENDONUCLEASE; SITE SPECIFIC DNA METHYLTRANSFERASE (ADENINE SPECIFIC);

ARTICLE; CANCER CELL LINE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENOME ANALYSIS; HUMAN; HUMAN CELL; INDEL MUTATION; POINT MUTATION; CRISPR CAS SYSTEM; GENETIC ENGINEERING; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

BACTERIAL PROTEINS; CELL LINE, TUMOR; CRISPR-CAS SYSTEMS; EMBRYONIC STEM CELLS; ENDODEOXYRIBONUCLEASES; ENDONUCLEASES; GENETIC ENGINEERING; HUMANS; RNA, GUIDE; SITE-SPECIFIC DNA-METHYLTRANSFERASE (ADENINE-SPECIFIC);

EID: 84937575600     PISSN: 10430342     EISSN: 15577422     Source Type: Journal    
DOI: 10.1089/hum.2015.084     Document Type: Article

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