Lentiviral vectors with a defective integrase allow efficient and sustained transgene expression in vitro and vivo

Proceedings of the National Academy of Sciences of the United States of America

Volumn 103, Issue 47, 2006, Pages 17684-17689

  Philippe, Stéphanie ^a   Sarkis, Chamsy ^a   Barkats, Martine ^a   Mammeri, Hamid ^a   Ladroue, Charline ^b   Petit, Caroline ^b   Mallet, Jacques ^a   Serguera, Che ^a  

^a SORBONNE UNIVERSITÉ   (France)

^b INSERM   (France)

Author keywords

HIV 1 derived vector; Integrase deficient; Stable transgene expression

Indexed keywords

COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; INTEGRASE; KANAMYCIN KINASE;

ARTICLE; BRAIN CELL; GENE EXPRESSION; GENE MUTATION; LENTIVIRINAE; LENTIVIRUS VECTOR; NONHUMAN; PRIORITY JOURNAL; TRANSGENE; VIRUS GENOME; VIRUS VECTOR;

ANIMALS; BRAIN; CELLS, CULTURED; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GENOME, VIRAL; HIV-1; HUMANS; INTEGRASES; LENTIVIRUS; MICE; PLASMIDS; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT FUSION PROTEINS; TRANSGENES;

HUMAN HERPESVIRUS 5; HUMAN IMMUNODEFICIENCY VIRUS 1; LENTIVIRUS;

EID: 33845187432     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0606197103     Document Type: Article

References (40)

1. Sakhuja K, Reddy PS, Ganesh S, Cantaniag F, Pattison S, Limbach P, Kayda DB, Kadan MJ, Kaleko M, Connelly S (2003) Hum Gene Ther 14:243-254.
2. Logvinoff C, Epstein AL (2001) Hum Gene Ther 12:161-167.
3. Kafri T, Blomer U, Peterson DA, Gage FH, Verma IM (1997) Nat Genet 17:314-317.
4. Abordo-Adesida E, Follenzi A, Barcia C, Sciascia S, Castro MG, Naldini L, Lowenstein PR (2005) Hum Gene Ther 16:741-751.
5. Hacein-Bey-Abina S, von Kalle C, Schmidt M, Le Deist F, Wulffraat N, McIntyre E, Radford I, Villeval JL, Fraser CC, Cavazzana-Calvo M, Fischer A (2003) N Engl J Med 348:255-256.
6. Wu X, Li Y, Crise B, Burgess SM (2003) Science 300:1749-1751.
7. Schroder AR, Shinn P, Chen H, Berry C, Ecker JR, Bushman F (2002) Cell 110:521-529.
8. Killebrew DA, Troelstrup D, Shiramizu B (2004) Cell Mol Biol 50:581-589.
9. Gallagher B, Wang Z, Schymura MJ, Kahn A, Fordyce EJ (2001) Am J Epidemiol 154:544-556.
10. Themis M, Waddington SN, Schmidt M, von Kalle C, Wang Y, Al-Allaf F, Gregory LG, Nivsarkar M, Holder MV, Buckley SM, et al. (2005) Mol Ther 12:763-771.
11. Coffin JM (1996) in Fields Virology, eds Fields NB, Knipe DM, Howley, PM, Chanock RM, Melnick JL, Monath TP, Roizman B, Straus SE (Lippincott-Raven, Philadelphia), pp 1767-1847.
12. Farnet CM, Haseltine WA (1991) J Virol 65:6942-6952.
13. Stevenson M, Haggerty S, Lamonica CA, Meier CM, Welch SK, Wasiak AJ (1990) J Virol 64:2421-2425.
14. Engelman A, Englund G, Orenstein JM, Martin MA, Craigie R (1995) J Virol 69:2729-2736.
15. Wiskerchen M, Muesing MA (1995) J Virol 69:376-386.
16. Nakajima N, Lu R, Engelman A (2001) J Virol 75:7944-7955.
17. Wu Y (2004) Retrovirology 1:13.
18. Petit C, Schwartz O, Mammano F (2000) J Virol 74:7119-7126.
19. Naldini L, Blomer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D (1996) Science 272:263-267.
20. Naldini L, Blomer U, Gage FH, Trono D, Verma IM (1996) Proc Natl Acad Sci USA 93:11382-11388.
21. Blomer U, Naldini L, Verma IM, Trono D, Gage FH (1996) Hum Mol Genet 5:1397-1404.
22. Loewen N, Leske DA, Chen Y, Teo WL, Saenz DT, Peretz M, Holmes JM, Poeschla EM (2003) J Genes Med 5:1009-1017.
23. Saenz DT, Loewen N, Peretz M, Whitwam T, Barraza R, Howell KG, Holmes JM, Good M, Poeschla EM (2004) J Virol 78:2906-2920.
24. Zennou V, Petit C, Guetard D, Nerhbass U, Montagnier L, Charneau P (2000) Cell 101:173-185.
25. Zennou V, Serguera C, Sarkis C, Colin P, Perret E, Mallet J, Charneau P (2001) Nat Biotechnol 19:446-450.
26. Follenzi A, Ailles LE, Bakovic S, Geuna M, Naldini L (2000) Nat Genet 25:217-222.
27. Whitwam T, Peretz M, Poeschla E (2001) J Virol 75:9407-9414.
28. Zufferey R, Donello JE, Trono D, Hope TJ (1999) J Virol 73:2886-2892.
29. Brun S, Faucon-Biguet N, Mallet J (2003) Mol Ther 7:782-789.
30. Miyoshi H, Blomer U, Takahashi M, Gage FH, Verma IM (1998) J Virol 72:8150-8157.
31. Zufferey R, Dull T, Mandel RJ, Bukovsky A, Quiroz D, Naldini L, Trono D (1998) J Virol 72:9873-9880.
32. Yanez-Munoz RJ, Balaggan KS, MacNeil A, Howe SJ, Schmidt M, Smith AJ, Buch P, MacLaren RE, Anderson PN, Barker SE, et al. (2006) Nat Med 12:348-353.
33. Schmidt M, Zickler P, Hoffmann G, Haas S, Wissler M, Muessig A, Tisdale JF, Kuramoto K, Andrews RG, Wu T, et al. (2002) Blood 100:2737-2743.
34. Chen H, Engelman A (2000) J Virol 74:8188-8193.
35. Ehrhardt A, Peng PD, Xu H, Meuse L, Kay MA (2003) Hum Gene Ther 14:215-225.
36. Chancham, P van Tjerperen T, McDoom I, Hughes JA (2003) J Drug Target 11:205-213.
37. Papapetrou EP, Ziros PG, Micheva ID, Zoumbos NC, Athanassassiadou A (2006) Gene Ther 13:40-51.
38. Cannon PM, Byles ED, Kingsman SM, Kingsman AJ (1996) J Virol 70:651-657.
39. Zufferey R, Nagy D, Mandel RJ, Naldini L, Trono D (1997) Nat Biotechnol 15:871-875.
40. Vogel R, Amar L, Thi AD, Saillour P, Mallet J (2004) Hum Gene Ther 15:157-165.