Selection-independent generation of gene knockout mouse embryonic stem cells using zinc-finger nucleases

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Osiak, Anna ^a,b,e   Radecke, Frank ^c   Guhl, Eva ^b   Radecke, Sarah ^d   Dannemann, Nadine ^a   Lütge, Fabienne ^a   Glage, Silke ^a   Rudolph, Cornelia ^a   Cantz, Tobias ^a   Schwarz, Klaus ^c,d   Heilbronn, Regine ^b   Cathomen, Toni ^a,b  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF ULM   (Germany)

^d University of Ulm   (Germany)

^e MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ZINC FINGER PROTEIN; ENDONUCLEASE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA REPAIR; DOWN REGULATION; EGFP GENE; EMBRYO; EMBRYONIC STEM CELL; EXPRESSION VECTOR; GENE DELETION; GENE DISRUPTION; GENE INACTIVATION; GENE INSERTION; GENE LOCUS; GENE TARGETING; GENETIC ENGINEERING; GENETIC SELECTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; MARKER GENE; MOUSE; NONHUMAN; NULL ALLELE; PLURIPOTENT STEM CELL; TRANSIENT EXPRESSION; X CHROMOSOME; ANIMAL; CHROMOSOME; CYTOLOGY; GENETICS; METABOLISM; METAPHASE; MOLECULAR GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; TUMOR CELL LINE;

ANIMALS; BASE SEQUENCE; CELL LINE, TUMOR; CHROMOSOMES, MAMMALIAN; EMBRYONIC STEM CELLS; ENDONUCLEASES; GENE KNOCKOUT TECHNIQUES; HUMANS; METAPHASE; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PLURIPOTENT STEM CELLS; ZINC FINGERS;

EID: 83355168678     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028911     Document Type: Article

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