The future promises of xenotransplantation

Annals of the New York Academy of Sciences

Volumn 862, Issue , 1998, Pages 5-18

  Platt, Jeffrey L ^a,b   Lin, Shu S ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFERENCE PAPER; GENETIC ENGINEERING; GENETICS; GRAFT REJECTION; HUMAN; IMMUNE RESPONSE; INFECTION RISK; NONHUMAN; ORGAN; ORGAN TRANSPLANTATION; PHYSIOLOGY; TISSUE; TISSUE TRANSPLANTATION; XENOTRANSPLANTATION;

ANIMALIA;

EID: 0032410893     PISSN: 00778923     EISSN: None     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.1998.tb09112.x     Document Type: Conference Paper

References (53)

1. 1. Evans, R.W., C.E. Orians & N.L. Asher. 1992. The potential supply of organ donors: An assessment of the efficiency of organ procurement efforts in the United States. JAMA 267: 239-246.
2. 2. Starzl, T.E., J. Fung, A. Tzakis, S. Todo, A.J. Demetris, I.R. Marino, H. Doyle, A. Zeevi, V. Warty, M. Michaels, S. Kusne, W.A. Rudert & M. Trucco. 1993. Baboon-to-human liver transplantation. Lancet 341: 65-71.
3. 3. Platt, J.L. 1995. Hyperacute Xenograft Rejection. Springer-Verlag. New York.
4. 4. Perper, R.J. & J.S. Najarian. 1966. Experimental renal heterotransplantation. I. In widely divergent species. Transplantation 4: 377-388.
5. 5. Giles, G.R., H.J. Boehmig, J. Lilly, H. Amemiya, H. Takagi, A.J. Coburg, W.E. Hathaway, C.B. Wilson, F.J. Dixon & T.E. Starzl. 1970. Mechanism and modification of rejection of heterografts between divergent species. Transpl. Proc. 2: 522-537.
6. 6. Boyden, S.V. 1964. Natural antibodies and the immune response. Advan. Immunol. 5: 1-28.
7. 7. Parker, W., P.B. Yu, Z.E. Holzknecht, K. Lundberg-Swanson, R.H. Buckley & J.L. Platt. 1997. Specificity and function of "natural" antibodies in immunodeficient subjects: Clues to B-cell lineage and development. J. Clin. Immunol. 17: 311-321.
8. 8. Good, A.H., D.K.C. Cooper, A.J. Malcolm, R.M. Ippolito, E. Koren, F.A. Neethling, Y.Ye, N. Zuhdi & L.R. Lamontagne. 1992. Identification of carbohydrate structures that bind human antiporcine antibodies: Implications for discordant xenografting in humans. Transpl. Proc. 24: 559-562.
9. 9. Sandrin, M.S., H.A. Vaughan, P.L. Dabkowski & I.F.C. McKenzie. 1993. Anti-pig IgM antibodies in human serum react predominantly with Galα(1,3)Gal epitopes. Proc. Natl. Acad. Sci. USA 90: 11391-11395.
10. 10. Collins, B.H., W. Parker & J.L. Platt. 1994. Characterization of porcine endothelial cell determinants recognized by human natural antibodies. Xenotransplantation 1: 36-46.
11. 11. Lin, S.S., D.L. Kooyman, L.J. Daniels, C.W. Dagget, W. Parker, J.H. Lawson, C.W. Hoopes, C. Gullotto, L. Li, P. Birch, R.D. Davis, L.E. Diamond, J.S. Logan & J.L. Platt. 1997. The role of natural anti-Galαl-3Gal antibodies in hyperacute rejection of pig-to-baboon cardiac xenotransplants. Transplant Immunol. 5: 212-218.
12. 12. Geller, R.L., P. Rubinstein & J.L. Platt. 1994. Variation in expression of porcine xenogeneic antigens. Transplantation 58: 272-277.
13. 13. Alvarado, C.G., A.H. Cotterell, K.R. McCurry, B.H. Collins, J.C. Magee, J. Berthold, J.S. Logan & J. Platt. 1995. Variation in the level of xenoantigen expression in porcine organs. Transplantation 59: 1589-1596.
14. 14. Tearle, R.G., M.J. Tange, Z.L. Zannettino, M. Katerelos, T.A. Shinkel, B.J.W. Van Denderen, A.J. Lonie, I. Lyons, M.B. Nottle, T. Cox, C. Becker, A.M. Peura, P.L. Wigley, R.J. Crawford, A.J. Robins, M.J. Pearse & A.J.F. D'Apice. 1996. The α-1,3-galactosyltransferase knockout mouse. Transplantation 61: 13-49.
15. 15. Thall, A.D., P. Maly & J.B. Lowe. 1997. Oocyte Galαl-3Gal epitopes implicated in sperm adhesion to the zone pellucida glycoprotein ZP3 are not required for fertilization in the mouse. J. Biol. Chem. 270: 21437-21440.
16. 16. Sandrin. M.S., W.L. Fodor E. Mouhtouris, N. Osman, S. Cohney, S.A. Rollins, E.R. Guilmette, E. Setter, S.P. Squinto & I. McKenzie. 1995. Enzymatic remodelling of the carbohydrate surface of a xenogeneic cell substantially reduces human antibody binding and complement-mediated cytolysis. Nature Medicine 1: 1261-1267.
17. 17. Sharma, A., J.F. Okabe, P. Birch, J.L. Platt & J.S. Logan. 1996. Reduction in the level of gal (α1,3) gal in transgenic mice and pigs by the expression of an α(1,2) fucosyltransferase. Proc. Natl. Acad. Sci. USA 93: 7190-7195.
18. 18. Platt, J.L., R.T. Fischel, A.T. Matas, S.A. Reif, R.M. Bolman & F.H. Bach. 1991. Immunopathology of hyperacute xenograft rejection in a swine-to-primate model. Transplantation 52: 214-220.
19. 19. Dalmasso, A.P., G.M. Vercellotti, R.J. Fischel, R.M. Bolman, F.H. Bach, & J.L. Platt. 1992. Mechanism of complement activation in the hyperacute rejection of porcine organs transplanted into primate recipients. Am. J. Pathol. 140: 1157-1166.
20. 20. Platt, J.L., G.M. Vercellotti, A.P. Dalmasso, A.J. Matas, R.M. Bolman, J.S. Najarian & F.H. Bach. 1990. Transplantation of discordant xenografts: A review of progress. Immunol. Today 11: 450-456.
21. 21. Hourcade, D., V.M. Holers & J.P. Atkinson. 1989. The regulators of complement activation (RCA) gene cluster. Advan. Immunol. 45: 381-416.
22. 22. Dalmasso, A.P., G.M. Vercellotti, J.L. Platt & F.H. Bach. 1991. Inhibition of complement-mediated endothelial cell cytotoxicity by decay accelerating factor: Potential for prevention of xenograft hyperacute rejection. Transplantation 52: 530-533.
23. 23. White, D. & J. Wallwork. 1993. Xenografting: probability, possibility, or pipe dream? Lancet 342: 879-880.
24. 24. McCurry, K.R., D.L. Kooyman, C.G. Alvarado, A.H. Cotterell, M.J. Martin, J.S. Logan & J.L. Platt. 1995. Human complement regulatory proteins protect swine-to-primate cardiac xenografts from humoral injury. Nature Med. 1: 423-427.
25. 25. Byrne, G.W., K.R. McCurry, M.J. Martin, S.M. McClellan, J.L. Platt, & J.S. Logan. 1997. Transgenic pigs expressing human CD59 and decay-accelerating factor produce an intrinsic barrier to complement-mediated damage. Transplantation 63: 149-155.
26. 26. McCurry, K.R., W. Parker, A.H. Cotterell, B.C. Weidner, S.S. Lin, L.J. Daniels, Z.E. Holzknecht, G.W. Byrne, L.E. Diamond, J.S. Logan & J.L. Platt. 1997. Humoral responses in pig-to-baboon cardiac transplantation: Implications for the pathogenesis and treatment of acute vascular rejection and for accommodation. Hum. Immunol. 58: 91-105..
27. 27. Cozzi, E., N. Yannoutsos, G.A. Langford, G. Pino-Chavez, J. Wallwork & D.J.G. White. 1997. Effect of transgenic expression of human decay-accelerating factor on the inhibition of hyperacute rejection of pig organs. In Xenotransplantation: The Transplantation of Organs and Tissues between Species. D.K.C. Cooper, E. Kemp, J.L. Platt, and D.J.G. White, Eds.: 665-682. Springer. Berlin.
28. 28. Leventhal, J.R., A.J. Matas, L.H. Sun, S. Reif, R.M. Bolman, III, A.P. Dalmasso & J.L. Platt. 1993. The immunopathology of cardiac xenograft rejection in the guinea pig to rat model. Transplantation 56: 1-8.
29. 29. Magee, J.C., B.H. Collins, R.C. Harland, B.J. Lindman, R.R. Bollinger, M.M. Frank & J.L. Platt. 1995. Immunoglobulin prevents complement mediated hyperacute rejection in swine-to-primate xenotransplantation. J. Clin. Invest. 96: 2404-2412.
30. 30. McPaul, J.J., P. Stastny & R.B. Freeman. 1981. Specificities of antibodies eluted from human cadaveric renal allografts. J. Clin. Invest. 67: 1405-1414.
31. 31. Lin, S.S., B.C. Weidner, G.W. Byrne, L.E. Diamond, J.H. Lawson, C.W. Hoopes, L.J. Daniels, C. Daggett, W. Parker, R.C. Harland, R.D. Davis, R.R. Bollinger, J. Logan & J.L. Platt. 1998. The role of antibodies in the acute vascular rejection of pig-to-baboon cardiac transplants. J. Clin. Invest. 101: 1745-1756.
32. 32. Perper, R.J. & J.S. Najarian. 1967. Experimental renal heterotransplantation. III. Passive transfer of transplantation immunity. Transplantation 5: 514-533.
33. 33. Cotterell, A.H., B.H. Collins, W. Parker, R.C. Harland & J.L. Platt. 1995. The humoral immune response in humans following cross-perfusion of porcine organs. Transplantation 60: 861-868.
34. 34. Blakely, M.L., W.J. Van Der Werf, M.C. Berndt, A.P. Dalmasso, F.H. Bach & W.W. Hancock. 1994. Activation of intragraft endothelial and mononuclear cells during discordant xenograft rejection. Transplantation 58: 1059-1066.
35. 35. Inverardi, L., B. Clissi, A.L. Stolzer, J.R. Bender & R. Pardi. 1996. Overlapping recognition of xenogeneic carbohydrate ligands by human natural killer lymphocytes and natural antibodies. Transpl. Proc. 28: 552.
36. 36. Chopek, M.W., R.L. Simmons & J.L. Platt. 1987. ABO incompatible renal transplantation: Initial immunopathologic evaluation. Transpl. Proc. 19: 4553-4557.
37. 37. Bach, F.H., C. Ferran, P. Hechenleitner, W. Mark, N. Koyamada, T. Miyatake, H. Winkler, A. Badrichani, D. Cardinas & W.H. Hancock. 1997. Accommodation of vascularized xenografts: expression of "protective genes" by donor endothelial cells in a host Th2 cytokine environment. Nature Med. 3: 196-204.
38. 38. Fearon, D.T. & R.M. Locksley. 1996. The instructive role of innate immunity in the acquired immune response. Science 272: 50-54.
39. 39. Inverardi, L., M. Samaja, R. Motterlini, F. Mangili, J.R. Bender & R. Pardi. 1992. Early recognition of a discordant xenogeneic organ by human circulating lymphocytes. J. Immunol. 149: 1416-1423.
40. 40. Lanier, L.L. & J.H. Phillips. 1996. Inhibitory MHC class I receptors on NK cells and T cells. Immunol. Today 17: 86-91.
41. 41. Alexandre, G.P.J., P. Gianello, D. Latinne, M. Carlier, A. Dewaele, L. Van Obbergh, M. Moriau, E. Marbaix, J.L Lambotte, L. Lambotte & J.P. Squifflet. 1989. Plasmapheresis and splenectomy in experimental renal xenotransplantation. In Xenograft 25. M.A. Hardy, Ed.: 259-266. Elsevier.
42. 42. Sablinski, T., D. Latinne, P. Gianello, M. Bailin, K. Bergen, R.B. Colvin, A. Foley, H. Hong, T. Lorf, S. Meehan, R. Monroy, T.A. Powelson, M. Sykes, M. Tanaka, A.B. Cosimi & D.H. Sachs. 1995. Xenotransplantation of pig kidneys to nonhuman primates: I. Development of the model. Xenotransplantation 2: 264-270.
43. 43. Daggett, C.W., M. Yeatman, E.P. Chen, A.J. Lodge, M. Srinivasan, G.W. Byrne, J.S. Logan, J.L. Platt & R.D. Davis. 1996. Transgenic swine-to-primate pulmonary xenotransplantation. Surg. Forum Am. Coll. Surg. XLVII: 413-415.
44. 44. Daggett, C.W., M. Yeatman, A.J. Lodge, E.P. Chen, C. Gullotto, M.M. Frank, J.L. Platt & R.D. Davis. 1998. Total respiratory support from swine lungs in primate recipients. J. Thorac. Cardiovasc. Surg. 115: 19-27.
45. 45. Akhter, S.A., C.A. Skaer, A.P. Kypson, P.H. McDonald, K.C. Peppel, D.D. Glower, R.J. Lefkowitz & W.J. Koch. 1997. Restoration of β-adrenergic signaling in failing cardiac ventricular myocytes via adenoviral-mediated gene transfer. Proc. Natl. Acad. Sci. USA 94: 12100-12105.
46. 46. Kypson, A.P., K. Peppel, S.A. Akhter, R.E. Lilly, D.D. Glower, R.J. Lefkowitz & W.J. Koch. 1998. Ex vivo adenoviral-mediated gene transfer to the adult rat heart. J. Thorac. Cardiovasc. Surg. 115: 623-630.
47. 47. Lawson, J.H. & J.L. Platt. 1996. Molecular barriers to xenotransplantation. Transplantation 62: 303-310.
48. 48. Patience, C., Y. Takeuchi & R.A. Weiss. 1997. Infection of human cells by an endogenous retrovirus of pigs. Nature Med. 3: 282-286.
49. 49. Sullenger, B.A., H.F. Gallardo, G.E. Ungers & E. Gilboa. 1990. Overexpression of TAR sequences renders cells resistant to human immunodeficiency virus replication. Cell 63: 601-608.
50. 50. Groth, C.G., O. Korsgren, A. Tibell, J. Tollemar, E. Moller, J. Bolinder, J. Ostman, F.P. Reinholt, C. Hellerstrom & A. Andersson. 1994. Transplantation of porcine fetal pancreas to diabetic patients. Lancet 344: 1402-1404.
51. 51. Chari, R.S., B.H. Collins, J.C. Magee, A.D. Kirk, R.C. Harland, R.L. McCann, J.L. Platt, & W.C. Meyers. 1994. Treatment of hepatic failure with ex-vivo pig liver perfusion followed by liver transplantation. N. Engl. J. Med. 331: 234-237.
52. 52. Deacon, T., J. Schumacher, J. Dinsmore, C. Thomas, P. Palmer, S. Kott, A. Edge, D. Penney, S. Kassissieh, P. Dempsey & O. Isacson. 1997. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nature Med. 3: 350-353.
53. 53. Zehr, K.J., A. Herskowitz, P.C. Lee, P. Kumar, A.M. Gillinov & W.A. Baumgartner. 1994. Neutrophil adhesion and complement inhibition prolongs survival of cardiac xenografts in discordant species. Transplantation 57: 900-906.