From noncoding variant to phenotype via SORT1 at the 1p13 cholesterol locus

Nature

Volumn 466, Issue 7307, 2010, Pages 714-719

  Musunuru, Kiran ^a,b,c   Strong, Alanna ^d   Frank Kamenetsky, Maria ^e   Lee, Noemi E ^a   Ahfeldt, Tim ^a,f   Sachs, Katherine V ^d   Li, Xiaoyu ^d   Li, Hui ^d   Kuperwasser, Nicolas ^a   Ruda, Vera M ^a   Pirruccello, James P ^a,b   Muchmore, Brian ^g   Prokunina Olsson, Ludmila ^g   Hall, Jennifer L ^b,h   Schadt, Eric E ⁱ   Morales, Carlos R ^j   Lund Katz, Sissel ^d   Phillips, Michael C ^d   Wong, Jamie ^e   Cantley, William ^e   Racie, Timothy ^e   Ejebe, Kenechi G ^a,b   Orho Melander, Marju ^k   Melander, Olle ^k,l   Koteliansky, Victor ^e   Fitzgerald, Kevin ^e   Krauss, Ronald M ^a,b   Cowan, Chad A ^a,b   Kathiresan, Sekar ^a,b   Rader, Daniel J ^d   more..

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e ALNYLAM PHARMACEUTICALS   (United States)

^f UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^g NATIONAL CANCER INSTITUTE   (United States)

^h UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

ⁱ SAGE BIONETWORKS   (United States)

^j MCGILL UNIVERSITY   (Canada)

^k LUND UNIVERSITY HOSPITAL   (Sweden)

^l CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN; CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; SMALL INTERFERING RNA; VERY LOW DENSITY LIPOPROTEIN; LIPID; SORTILIN; VESICULAR TRANSPORT ADAPTOR PROTEIN;

CHROMOSOME; GENE EXPRESSION; GENETIC ANALYSIS; GENOME; PHENOTYPE; RODENT;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CHOLESTEROL BLOOD LEVEL; CHROMOSOME 1P; CONTROLLED STUDY; GENE; GENE EXPRESSION; GENE LOCUS; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; HUMAN CELL; LIPOPROTEIN METABOLISM; LIVER CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SECRETION; SINGLE NUCLEOTIDE POLYMORPHISM; SORT1 GENE; ANIMAL; BIOSYNTHESIS; BLOOD; CELL CULTURE; CHROMOSOME 1; COHORT ANALYSIS; CORONARY ARTERY DISEASE; CYTOLOGY; DEFICIENCY; ETHNOLOGY; EUROPE; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC PREDISPOSITION; GENETICS; HEART INFARCTION; LIVER; METABOLISM; NUCLEOTIDE SEQUENCE; SECRETION (PROCESS);

ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; BASE SEQUENCE; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; CELLS, CULTURED; CHOLESTEROL, LDL; CHROMOSOMES, HUMAN, PAIR 1; COHORT STUDIES; CORONARY ARTERY DISEASE; EUROPE; GENE EXPRESSION REGULATION; GENE KNOCKDOWN TECHNIQUES; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; HAPLOTYPES; HEPATOCYTES; HUMANS; LIPIDS; LIPOPROTEINS, VLDL; LIVER; MICE; MYOCARDIAL INFARCTION; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; TRANSCRIPTION, GENETIC;

EID: 77955499945     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09266     Document Type: Article

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