Correction of the Crb1rd8 allele and retinal phenotype in C57BL/6N mice via TALEN-mediated homology-directed repair

Investigative Ophthalmology and Visual Science

Volumn 55, Issue 1, 2013, Pages 387-395

  Low, Benjamin E ^a   Krebs, Mark P ^a   Joung, J Keith ^b   Tsai, Shengdar Q ^c   Nishina, Patsy M ^a   Wiles, Michael V ^a  

^a JACKSON LABORATORY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

CRB1 associated disease; Gene therapy; Genetic engineering; KOMP; TALEN

Indexed keywords

MESSENGER RNA; OLIGONUCLEOTIDE; RESTRICTION ENDONUCLEASE; TRANSCRIPTION ACTIVATOR LIKE EFFECTOR NUCLEASE; UNCLASSIFIED DRUG; CRB1 PROTEIN, MOUSE; EYE PROTEIN; NERVE PROTEIN;

ALLELE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRB1 GENE; FEMALE; FLUORESCENCE MICROSCOPY; GENE; GENE MUTATION; GENE THERAPY; MALE; MICROINJECTION; MOUSE; NONHUMAN; OOCYTE; OPTICAL COHERENCE TOMOGRAPHY; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RETINA DISEASE; RETINA MALFORMATION; SINGLE NUCLEOTIDE POLYMORPHISM; TARGETED GENE REPAIR; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; CRB1 ASSOCIATED DISEASE; DISEASE MODEL; EMBRYONIC STEM CELL; GENETIC ENGINEERING; GENETICS; KOMP; METABOLISM; METHODOLOGY; MUTATION; PATHOLOGY; RECOMBINATION REPAIR; RETINA; RETINA DEGENERATION; TALEN;

CRB1 ASSOCIATED DISEASE; GENE THERAPY; GENETIC ENGINEERING; KOMP; TALEN;

ALLELES; ANIMALS; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; EYE PROTEINS; FEMALE; GENETIC THERAPY; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; MUTATION; NERVE TISSUE PROTEINS; PHENOTYPE; POLYMERASE CHAIN REACTION; RECOMBINATIONAL DNA REPAIR; RETINA; RETINAL DEGENERATION; TOMOGRAPHY, OPTICAL COHERENCE;

EID: 84892689751     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.13-13278     Document Type: Article

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