Aggressive organ donor management protocol

Journal of Intensive Care Medicine

Volumn 23, Issue 6, 2008, Pages 367-375

  DuBose, Joseph ^a   Salim, Ali ^b  

^a LAC USC MEDICAL CENTER   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Aggressive donor management; Brain death; In house coordinator; Organ donation; Organ donor; Solid organ transplant; Transplantation

Indexed keywords

ADRENALIN; DIURETIC AGENT; DOPAMINE; GLUCOSE; HYPERTENSIVE FACTOR; INSULIN; METHYLPREDNISOLONE SODIUM SUCCINATE; STEROID; THYROID HORMONE;

BRAIN DEATH; CADAVER; CONTINUOUS INFUSION; DIABETES INSIPIDUS; DISSEMINATED INTRAVASCULAR CLOTTING; FLUID RESUSCITATION; GRAFT SURVIVAL; HEALTH EDUCATION; HEART ARRHYTHMIA; HEART DEATH; HORMONAL THERAPY; HOSPITAL ADMISSION; HYPOTHERMIA; INTENSIVE CARE; LUNG EDEMA; MEAN ARTERIAL PRESSURE; MEDICAL ERROR; NEUROGENIC PULMONARY EDEMA; ORGAN DONOR; ORGAN TRANSPLANTATION; PATHOPHYSIOLOGY; PATIENT MONITORING; PATIENT SELECTION; PHYSIOLOGY; PRACTICE GUIDELINE; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; REVIEW; SHOCK;

BRAIN DEATH; HUMANS; TISSUE AND ORGAN PROCUREMENT; TISSUE DONORS; WAITING LISTS;

EID: 57049151425     PISSN: 08850666     EISSN: 15251489     Source Type: Journal    
DOI: 10.1177/0885066608324208     Document Type: Review

References (80)

1. Organ Procurement and Transplantation Network Web-site. 2007. Available at: http://www.optn.org/. Accessed July 26, 2007.
2. U.S. Department of Health and Human Services. Organ donation breakthrough collaborative: from best practice to common practice. 2007. Available at: http://www.organdonationnow.org/. Accessed July 26, 2007.
3. Rosendale JD, Kauffman HM, McBride MA, et al. Aggressive pharmacologic donor management results in more transplanted organs. Transplantation. 2003 ; 75: 482-487.
4. Hauptman PJ, O'Connor KJ Procurement and allocation of solid organs for transplantation. N Engl J Med. 1997 ; 336: 422-431.
5. Gridelli B., Remuzzi G. Strategies for making more organs available for transplantation. N Engl J Med. 2000 ; 343: 404-410.
6. Teperman LW Transplantation. J Am Coll Surg. 1999 ; 188: 184-190.
7. Alexander JW, Zola JC Expanding the donor pool: use of marginal donors for solid organ transplantation. Clin Transplant. 1996 ; 10: 1-19.
8. Foster R., Zimmerman M., Trotter JF Expanding donor options: marginal, living, and split donors. Clin Liver Dis. 2007 ; 11: 417-429.
9. Barshes NR, Horwitz IB, Franzini L., Vierling JM, Goss JA Waitlist mortality decreases with increased use of extended criteria donor liver grafts at adult liver transplant centers. Am J Transplant. 2007 ; 7: 1265-1270.
10. Navarro AP, Sohrabi S., Wyrley-Birch H., et al. Dual renal transplantation for kidneys from marginal nonheart-beating donors. Transplant Proc. 2006 ; 38: 2633-2634.
11. Studer SM, Orens JB Cadaveric donor selection and management. Semin Respir Crit Care Med. 2006 ; 27: 492-500.
12. Abt PL, Fisher CA, Singhal AK Donation after cardiac death in the US: history and use. J Am Coll Surg. 2006 ; 203: 208-225.
13. Steinbrook R. Organ donation after cardiac death. N Engl J Med. 2007 ; 357: 209-213.
14. Kootstra G. Statement on non-heart-beating donor programs. Transplant Proc. 1995 ; 27: 2965.
15. Kootstra G., Daemen JH The non-heart-beating donor. Transplant Proc. 1996 ; 28: 16.
16. Siminoff LA, Mercer MB Public policy, public opinion, and consent for organ donation. Camb Q Healthc Ethics. 2001 ; 10: 377-386.
17. Delmonico FL Exchanging kidneys-advances in living-donor transplantation. N Engl J Med. 2004 ; 350: 1812-1814.
18. Goody AJ Donor exchange for renal transplantation. N Engl J Med. 2004 ; 351: 935-937 ; author reply 935-937.
19. Truog RD The ethics of organ donation by living donors. N Engl J Med. 2005 ; 353: 444-446.
20. Department of Health and Human resources. Centers for disease control and prevention. 2007. Available at: http://www.cdc.gov/nchs/injury.htm. Accessed July 26, 2007.
21. Power BM, Van Heerden PV The physiological changes associated with brain death-current concepts and implications for treatment of the brain dead organ donor. Anaesth Intensive Care. 1995 ; 23: 26-36.
22. Smith M. Physiologic changes during brain stem death-lessons for management of the organ donor. J Heart Lung Transplant. 2004 ; 23: S217 - S222.
23. Salter DR, Dyke CM, Wechsler AS Triiodothyronine (T3) and cardiovascular therapeutics: a review. J Card Surg. 1992 ; 7: 363-374.
24. Novitzky D., Horak A., Cooper DK, Rose AG Electrocardiographic and histopathologic changes developing during experimental brain death in the baboon. Transplant Proc. 1989 ; 21: 2567-2569.
25. Cooper DK, Novitzky D., Wicomb WN The pathophysiological effects of brain death on potential donor organs, with particular reference to the heart. Ann R Coll Surg Engl. 1989 ; 71: 261-266.
26. Novitzky D., Cooper DK, Reichart B. Value of triiodothyronine (T3) therapy to brain-dead potential organ donors. J Heart Transplant. 1986 ; 5: 486-487.
27. Novitzky D., Cooper DK, Reichart B. Hemodynamic and metabolic responses to hormonal therapy in brain-dead potential organ donors. Transplantation. 1987 ; 43: 852-854.
28. Wicomb WN, Cooper DK, Novitzky D. Impairment of renal slice function following brain death, with reversibility of injury by hormonal therapy. Transplantation. 1986 ; 41: 29-33.
29. Novitzky D., Cooper DK, Morrell D., Isaacs S. Change from aerobic to anaerobic metabolism after brain death, and reversal following triiodothyronine therapy. Transplantation. 1988 ; 45: 32-36.
30. Smrcka M., Mrlian A., Klabusay M. Immune system status in the patients after severe brain injury. Bratisl Lek Listy. 2005 ; 106: 144-146.
31. Bredbacka S., Edner G. Soluble fibrin and D-dimer as detectors of hypercoagulability in patients with isolated brain trauma. J Neurosurg Anesthesiol. 1994 ; 6: 75-82.
32. Pathak A., Dutta S., Marwaha N., Singh D., Varma N., Mathuriya SN Change in tissue thromboplastin content of brain following trauma. Neurol India. 2005 ; 53: 178-182.
33. Stein SC, Smith DH Coagulopathy in traumatic brain injury. Neurocrit Care. 2004 ; 1: 479-488.
34. Bayir A., Kalkan E., Kocak S., Ak A., Cander B., Bodur S. Fibrinolytic markers and neurologic outcome in traumatic brain injury. Neurol India. 2006 ; 54: 363-365.
35. Nekludov M., Antovic J., Bredbacka S., Blomback M. Coagulation abnormalities associated with severe isolated traumatic brain injury: cerebral arterio-venous differences in coagulation and inflammatory markers. J Neuro-trauma. 2007 ; 24: 174-180.
36. Affonseca CA, Carvalho LF, Guerra SD, Ferreira AR, Goulart EM Coagulation disorder in children and adolescents with moderate to severe traumatic brain injury. J Pediatr (Rio J). 2007 ; 83: 274-282.
37. Aiyagari V., Menendez JA, Diringer MN Treatment of severe coagulopathy after gunshot injury to the head using recombinant activated factor VII. J Crit Care. 2005 ; 20: 176-179.
38. Novitzky D., Cooper DK, Chaffin JS, Greer AE, DeBault LE, Zuhdi N. Improved cardiac allograft function following triiodothyronine therapy to both donor and recipient. Transplantation. 1990 ; 49: 311-316.
39. Novitzky D. Novel actions of thyroid hormone: the role of triiodothyronine in cardiac transplantation. Thyroid. 1996 ; 6: 531-536.
40. Zuppa AF, Nadkarni V., Davis L., et al. The effect of a thyroid hormone infusion on vasopressor support in critically ill children with cessation of neurologic function. Crit Care Med. 2004 ; 32: 2318-2322.
41. Salim A., Martin M., Brown C., et al. Using thyroid hormone in brain-dead donors to maximize the number of organs available for transplantation. Clin Transplant. 2007 ; 21: 405-409.
42. Masson F., Thicoipe M., Latapie MJ, Maurette P. Thyroid function in brain-dead donors. Transpl Int. 1990 ; 3: 226-233.
43. Salim A., Martin M., Brown C., Belzberg H., Rhee P., Demetriades D. Complications of brain death: frequency and impact on organ retrieval. Am Surg. 2006 ; 72: 377-381.
44. Jenkins DH, Reilly PM, Schwab CW Improving the approach to organ donation: a review. World J Surg. 1999 ; 23: 644-649.
45. Ullah S., Zabala L., Watkins B., Schmitz ML Cardiac organ donor management. Perfusion. 2006 ; 21: 93-98.
46. Powner DJ, Darby JM, Kellum JA Proposed treatment guidelines for donor care. Prog Transplant. 2004 ; 14: 16-26 ; quiz 27-28.
47. Salim A., Velmahos GC, Brown C., Belzberg H., Demetriades D. Aggressive organ donor management significantly increases the number of organs available for transplantation. J Trauma. 2005 ; 58: 991-994.
48. Salim A., Martin M., Brown C., Rhee P., Demetriades D., Belzberg H. The effect of a protocol of aggressive donor management: implications for the national organ donor shortage. J Trauma. 2006 ; 61: 429-433 ; discussion 433-435.
49. Salim A., Brown C., Inaba K., et al. Improving consent rates for organ donation: the effect of an inhouse coordinator program. J Trauma. 2007 ; 62: 1411-1414 ; discussion 1414-1415.
50. Dodd-McCue D., Tartaglia A., Veazey KW, Streetman PS The impact of protocol on nurses' role stress: a longitudinal perspective. J Nurs Adm. 2005 ; 35: 205-216.
51. Roth BJ, Sher L., Murray JA, et al. Cadaveric organ donor recruitment at los angeles county hospital: improvement after formation of a structured clinical, educational and administrative service. Clin Transplant. 2003 ; 17 (suppl 9). 52-57.
52. Wheeldon DR, Potter CD, Dunning J., et al. Haemodynamic correction in multiorgan donation. Lancet. 1992 ; 339: 1175.
53. Straznicka M., Follette DM, Eisner MD, Roberts PF, Menza RL, Babcock WD Aggressive management of lung donors classified as unacceptable: excellent recipient survival one year after transplantation. J Thorac Cardiovasc Surg. 2002 ; 124: 250-258.
54. Rosendale JD, Chabalewski FL, McBride MA, et al. Increased transplanted organs from the use of a standardized donor management protocol. Am J Transplant. 2002 ; 2: 761-768.
55. Forget AP, Roumilhac D., Hazzan M., Pruvot FR, Noel C., Krivosic-Horber R. Evaluation of verification of brain death and coordination with hospital organ procurement at the university hospital at lille. Ann Fr Anesth Reanim. 2002 ; 21: 550-557.
56. Kennedy AP Jr, West JC, Kelley SE, Brotman S. Utilization of trauma-related deaths for organ and tissue harvesting. J Trauma. 1992 ; 33: 516-519 ; discussion 519-520.
57. Angel LF, Levine DJ, Restrepo MI, et al. Impact of a lung transplantation donor-management protocol on lung donation and recipient outcomes. Am J Respir Crit Care Med. 2006 ; 174: 710-716.
58. Braverman JM Increasing the quantity of lungs for transplantation using high-frequency chest wall oscillation: a proposal. Prog Transplant. 2002 ; 12: 266-274.
59. Powner DJ, Hewitt MJ, Levine RL Interventions during donor care before lung transplantation. Prog Transplant. 2005 ; 15: 141-148.
60. Prodhan P., Casavant D., Medlock MD, Yager P., Kim J., Noviski N. Inhaled nitric oxide in neurogenic cardiopulmonary dysfunction: implications for organ donation. Transplant Proc. 2004 ; 36: 2570-2572.
61. Linyear AS, Tartaglia A. Family communication coordination: a program to increase organ donation. J Transpl Coord. 1999 ; 9: 165-174.
62. Franz HG, DeJong W., Wolfe SM, et al. Explaining brain death: a critical feature of the donation process. J Transpl Coord. 1997 ; 7: 14-21.
63. Vane DW, Sartorelli KH, Reese J. Emotional considerations and attending involvement ameliorates organ donation in brain dead pediatric trauma victims. J Trauma. 2001 ; 51: 329-331.
64. Chang GJ, Mahanty HD, Ascher NL, Roberts JP Expanding the donor pool: can the spanish model work in the united states ? Am J Transplant. 2003 ; 3: 1259-1263.
65. Shafer T., Wood RP, Van Buren CT, et al. A success story in minority donation: the LifeGift/Ben taub general hospital in-house coordinator program. Transplant Proc. 1997 ; 29: 3753-3755.
66. Shafer T., Wood RP, Van Buren C., et al. An in-house coordinator program to increase organ donation in public trauma hospitals. J Transpl Coord. 1998 ; 8: 82-87.
67. Sullivan H., Blakely D., Davis K. An in-house coordinator program to increase organ donation in public teaching hospitals. J Transpl Coord. 1998 ; 8: 40-42.
68. Shafer TJ, Durand R., Hueneke MJ, et al. Texas non-donor-hospital project: a program to increase organ donation in community and rural hospitals. J Transpl Coord. 1998 ; 8: 146-152.
69. Shafer TJ, Davis KD, Holtzman SM, Van Buren CT, Crafts NJ, Durand R. Location of in-house organ procurement organization staff in level I trauma centers increases conversion of potential donors to actual donors. Transplantation. 2003 ; 75: 1330-1335.
70. Shafer TJ, Ehrle RN, Davis KD, et al. Increasing organ recovery from level I trauma centers: the in-house coordinator intervention. Prog Transplant. 2004 ; 14: 250-263.
71. Marks WH, Wagner D., Pearson TC, et al. Organ donation and utilization, 1995-2004: entering the collaborative era. Am J Transplant. 2006 ; 6: 1101-1110.
72. D'Alessandro AM, Fernandez LA, Chin LT, et al. Donation after cardiac death: the university of wisconsin experience. Ann Transplant. 2004 ; 9: 68-71.
73. DuBois JM Non-heart-beating organ donation. designing an ethically acceptable protocol. Health Prog. 2001 ; 82: 18-21.
74. Institute of Medicine, ed. Non-Heart-Beating Organ Transplantation: Medical and Ethical Issues in Procurement. In: Washington, DC: National Academy Press ; 1997.
75. Whetstine L., Bowman K., Hawryluck L. Pro/con ethics debate: is nonheart-beating organ donation ethically acceptable ? Crit Care. 2002 ; 6: 192-195.
76. Spielman B., McCarthy CS Beyond pittsburgh: protocols for controlled non-heart-beating cadaver organ recovery. Kennedy Inst Ethics J. 1995 ; 5: 323-333.
77. Herdman R., Beauchamp TL, Potts JT The institute of medicine's report on non-heart-beating organ transplantation. Kennedy Inst Ethics J. 1998 ; 8: 83-90.
78. Durall AL, Laussen PC, Randolph AG Potential for donation after cardiac death in a children's hospital. Pediatrics. 2007 ; 119: e219 - e224.
79. Reiner M., Cornell D., Howard RJ Development of a successful non-heart-beating organ donation program. Prog Transplant. 2003 ; 13: 225-231.
80. Sanchez-Fructuoso AI, Prats D., Torrente J., et al. Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool. J Am Soc Nephrol. 2000 ; 11: 350-358.