Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells

Development (Cambridge)

Volumn 141, Issue 1, 2014, Pages 219-223

  Kearns, Nicola A ^a   Genga, Ryan M J ^a   Enuameh, Metewo S ^a   Garber, Manuel ^a   Wolfe, Scot A ^a   Maehr, René ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

Cas9; CRISPR; Differentiation; Gene activation; Pluripotent stem cell; Transcriptional repression

Indexed keywords

DNA BINDING PROTEIN; DOXYCYCLINE; LENTIVIRUS VECTOR; NEOMYCIN; OCTAMER TRANSCRIPTION FACTOR 4; PROTEIN CAS 9; PUROMYCIN; RNA POLYMERASE II; TRANSCRIPTION FACTOR SOX17; UNCLASSIFIED DRUG;

ARTICLE; CELL DIFFERENTIATION; CELL FATE; COMPARATIVE STUDY; CONTROLLED STUDY; EMBRYONIC STEM CELL; ENDODERM; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOREACTIVITY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPRESSOR GENE; TRANSCRIPTION REGULATION;

CAS9; CRISPR; DIFFERENTIATION; GENE ACTIVATION; PLURIPOTENT STEM CELL; TRANSCRIPTIONAL REPRESSION;

AMINO ACID SEQUENCE; CASPASE 9; CELL DIFFERENTIATION; CELL LINEAGE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; DNA-BINDING PROTEINS; EMBRYONIC STEM CELLS; GENE REGULATORY NETWORKS; HEK293 CELLS; HUMANS; MOLECULAR SEQUENCE DATA; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; SOXF TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION;

EID: 84890460786     PISSN: 09501991     EISSN: 14779129     Source Type: Journal    
DOI: 10.1242/dev.103341     Document Type: Article

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