Zinc-finger nickase-mediated insertion of the lysostaphin gene into the beta-casein locus in cloned cows

Nature Communications

Volumn 4, Issue , 2013, Pages

  Liu, Xu ^a   Wang, Yongsheng ^a   Guo, Wenjiang ^a   Chang, Bohao ^a   Liu, Jun ^a   Guo, Zekun ^a   Quan, Fusheng ^a   Zhang, Yong ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CASEIN; LYSOSTAPHIN; ZINC FINGER NUCLEASE;

BACTERIUM; CATTLE; CLONE; DISEASE TREATMENT; ENZYME ACTIVITY; GENE EXPRESSION; HOMOLOGY; MILK; PIG; TECHNOLOGICAL DEVELOPMENT; ZINC;

ANIMAL CELL; ARTICLE; BACTERIOLYSIS; CELL NUCLEUS TRANSPLANTATION; CONTROLLED STUDY; COW; EMBRYO; FEMALE; FETUS; FIBROBLAST; GENE INSERTION; GENE LOCUS; GENE TARGETING; IN VITRO STUDY; IN VIVO STUDY; MILK; NONHUMAN; SOMATIC CELL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTI-INFECTIVE AGENTS, LOCAL; BACTERIAL PROTEINS; BASE SEQUENCE; CASEINS; CATTLE; CLONING, ORGANISM; ENDONUCLEASES; FEMALE; GENETIC LOCI; LACTATION; LYSOSTAPHIN; MILK; MOLECULAR SEQUENCE DATA; MUTAGENESIS, INSERTIONAL; NUCLEAR TRANSFER TECHNIQUES; STAPHYLOCOCCUS AUREUS; TRANSGENES; ZINC FINGERS;

EID: 84886931066     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms3565     Document Type: Article

References (42)

1. Hauschild, J. et al. Efficient generation of a biallelic knockout in pigs using zincfinger nucleases. Proc. Natl Acad. Sci. USA 108, 12013-12017 (2011).
2. Bibikova, M., Golic, M., Golic, K. G. & Carroll, D. Targeted chromosomal cleavage and mutagenesis in Drosophila using zinc-finger nucleases. Genetics 161, 1169-1175 (2002). (Pubitemid 34831440)
3. Urnov, F. D. et al. Highly efficient endogenous human gene correction using designed zinc-finger nucleases. Nature 435, 646-651 (2005). (Pubitemid 40825505)
4. Maeder, M. L. et al. Rapid 'open-source' engineering of customized zinc-finger nucleases for highly efficient gene modification. Mol. Cell 31, 294-301 (2008). (Pubitemid 352001401)
5. Kim, H. J., Lee, H. J., Kim, H., Cho, S. W. & Kim, J. S. Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly. Genome Res. 19, 1279-1288 (2009).
6. Kim, S., Lee, M. J., Kim, H., Kang, M. & Kim, J. S. Preassembled zinc-finger arrays for rapid construction of ZFNs. Nat. Methods 8, 7 (2011).
7. Yu, S. et al. Highly efficient modification of beta-lactoglobulin (BLG) gene via zinc-finger nucleases in cattle. Cell Res. 21, 1638-1640 (2011).
8. Fattah, F. et al. Ku regulates the non-homologous end joining pathway choice of DNA double-strand break repair in human somatic cells. PLoS Genet. 6, e1000855 (2010).
9. Cornu, T. I. et al. DNA-binding specificity is a major determinant of the activity and toxicity of zinc-finger nucleases. Mol. Ther. 16, 352-358 (2008). (Pubitemid 351187464)
10. Holliday, R. The Induction of Mitotic Recombination by Mitomycin C in Ustilago and Saccharomyces. Genetics 50, 323-335 (1964).
11. Meselson, M. S. & Radding, C. M. A general model for genetic recombination. Proc. Natl Acad. Sci. USA 72, 358-361 (1975).
12. Radding, C. M. Homologous pairing and strand exchange in genetic recombination. Annu. Rev. Genet. 16, 405-437 (1982).
13. Wang, J. et al. Targeted gene addition to a predetermined site in the human genome using a ZFN-based nicking enzyme. Genome Res. 22, 1316-1326 (2012).
14. Schuhardt, V. T. & Schindler, C. A. Lysostaphin Therapy in Mice Infected with Staphylococcus Aureus. J. Bacteriol. 88, 815-816 (1964).
15. Bramley, A. J. & Foster, R. Effects of lysostaphin on Staphylococcus aureus infections of the mouse mammary gland. Res. Vet. Sci. 49, 120-121 (1990). (Pubitemid 20289911)
16. Kerr, D. E. et al. Lysostaphin expression in mammary glands confers protection against staphylococcal infection in transgenic mice. Nat. Biotechnol. 19, 66-70 (2001). (Pubitemid 32051959)
17. Wall, R. J. et al. Genetically enhanced cows resist intramammary Staphylococcus aureus infection. Nat. Biotechnol. 23, 445-451 (2005). (Pubitemid 41724919)
18. Bitinaite, J., Wah, D. A., Aggarwal, A. K. & Schildkraut, I. FokI dimerization is required for DNA cleavage. Proc. Natl Acad. Sci. USA 95, 10570-10575 (1998). (Pubitemid 28413108)
19. Sanders, K. L., Catto, L. E., Bellamy, S. R. & Halford, S. E. Targeting individual subunits of the FokI restriction endonuclease to specific DNA strands. Nucleic Acids Res. 37, 2105-2115 (2009).
20. Kim, E. et al. Precision genome engineering with programmable DNA-nicking enzymes. Genome Res. 22, 1327-1333 (2012).
21. Renard, J. P. et al. Lymphoid hypoplasia and somatic cloning. Lancet 353, 1489-1491 (1999).
22. Kato, Y. et al. Eight calves cloned from somatic cells of a single adult. Science 282, 2095-2098 (1998). (Pubitemid 29001268)
23. Hill, J. R. et al. Development rates of male bovine nuclear transfer embryos derived from adult and fetal cells. Biol. Reprod. 62, 1135-1140 (2000). (Pubitemid 30238462)
24. Constant, F. et al. Large offspring or large placenta syndrome? Morphometric analysis of late gestation bovine placentomes from somatic nuclear transfer pregnancies complicated by hydrallantois. Biol. Reprod. 75, 122-130 (2006). (Pubitemid 43946347)
25. Yang, L. et al. Expression of imprinted genes is aberrant in deceased newborn cloned calves and relatively normal in surviving adult clones. Mol. Reprod. Dev. 71, 431-438 (2005). (Pubitemid 40923509)
26. Kubota, C. et al. Six cloned calves produced from adult fibroblast cells after long-term culture. Proc. Natl Acad. Sci. USA 97, 990-995 (2000). (Pubitemid 30080800)
27. Kubota, C., Tian, X. C. & Yang, X. Serial bull cloning by somatic cell nuclear transfer. Nat. Biotechnol. 22, 693-694 (2004). (Pubitemid 38702824)
28. Ball, S., Polson, K., Emeny, J., Eyestone, W. & Akers, R. M. Induced lactation in prepubertal Holstein heifers. J. Dairy Sci. 83, 2459-2463 (2000).
29. Ramirez, C. L. et al. Engineered zinc finger nickases induce homology-directed repair with reduced mutagenic effects. Nucleic Acids Res. 40, 5560-5568 (2012).
30. Gordon, K. et al. Production of human tissue plasminogen activator in transgenic mouse milk. 1987. Biotechnology 24, 425-428 (1992).
31. Wall, R. J. et al. High-level synthesis of a heterologous milk protein in the mammary glands of transgenic swine. Proc. Natl Acad. Sci. USA 88, 1696-1700 (1991). (Pubitemid 21916292)
32. Wright, G. et al. High level expression of active human alpha-1-antitrypsin in the milk of transgenic sheep. Biotechnology (NY) 9, 830-834 (1991).
33. Ebert, K. M. et al. Transgenic production of a variant of human tissue-type plasminogen activator in goat milk: generation of transgenic goats and analysis of expression. Biotechnology (NY) 9, 835-838 (1991).
34. Krimpenfort, P. et al. Generation of transgenic dairy cattle using 'in vitro' embryo production. Biotechnology (NY) 9, 844-847 (1991).
35. Maga, E. A., Anderson, G. B., Huang, M. C. & Murray, J. D. Expression of human lysozyme mRNA in the mammary gland of transgenic mice. Transgenic Res. 3, 36-42 (1994). (Pubitemid 2039113)
36. Whyte, J. J. et al. Gene targeting with zinc finger nucleases to produce cloned eGFP knockout pigs. Mol. Reprod. Dev. 78, 2 (2011).
37. Yang, D. et al. Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res. 21, 979-982 (2011).
38. Carlson, D. F. et al. Efficient TALEN-mediated gene knockout in livestock. Proc. Natl Acad. Sci. USA 109, 17382-17387 (2012).
39. Hwang, W. Y. et al. Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol. 31, 227-229 (2013).
40. Cho, S. W., Kim, S., Kim, J. M. & Kim, J. S. Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease. Nat. Biotechnol. 31, 230-232 (2013).
41. Beurdeley, M. et al. Compact designer TALENs for efficient genome engineering. Nat. Commun. 4, 1762 (2013).
42. McMaster, G. K. & Carmichael, G. G. Analysis of single-and double-stranded nucleic acids on polyacrylamide and agarose gels by using glyoxal and acridine orange. Proc. Natl Acad. Sci. USA 74, 4835-4838 (1977). (Pubitemid 8227018)