One-step generation of different immunodeficient mice with multiple gene modifications by CRISPR/Cas9 mediated genome engineering

International Journal of Biochemistry and Cell Biology

Volumn 46, Issue 1, 2014, Pages 49-55

  Zhou, Jiankui ^a   Shen, Bin ^a   Zhang, Wensheng ^b   Wang, Jianying ^a   Yang, Jing ^a   Chen, Li ^a   Zhang, Na ^c   Zhu, Kai ^c   Xu, Juan ^a   Hu, Bian ^a   Leng, Qibin ^c   Huang, Xingxu ^a  

^a NANJING UNIVERSITY   (China)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^c INSTITUTE PASTEUR OF SHANGHAI   (China)

Author keywords

Cas9; Gene targeting; Immunodeficient; Mouse; Multiple

Indexed keywords

CAS9 ENDONUCLEASE; ENDONUCLEASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DNA MODIFICATION; EXON; GENE DELETION; GENE EXPRESSION; GENE TARGETING; GENETIC ENGINEERING; GENOMIC FRAGMENT; KNOCKOUT GENE; MOUSE; MOUSE STRAIN; NONHUMAN;

CAS9; GENE TARGETING; IMMUNODEFICIENT; MOUSE; MULTIPLE;

ANIMALS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; FEMALE; GENE TARGETING; GENETIC ENGINEERING; GENOME; IMMUNOLOGIC DEFICIENCY SYNDROMES; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED CBA; RNA, GUIDE; RNA, MESSENGER;

EID: 84889855901     PISSN: 13572725     EISSN: 18785875     Source Type: Journal    
DOI: 10.1016/j.biocel.2013.10.010     Document Type: Article

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