Rescue of DNA-PK Signaling and T-Cell Differentiation by Targeted Genome Editing in a prkdc Deficient iPSC Disease Model

PLoS Genetics

Volumn 11, Issue 5, 2015, Pages

  Rahman, Shamim H ^a,b   Kuehle, Johannes ^b   Reimann, Christian ^a   Mlambo, Tafadzwa ^a,c   Alzubi, Jamal ^a,b   Maeder, Morgan L ^d,e   Riedel, Heimo ^b,f   Fisch, Paul ^a   Cantz, Tobias ^b   Rudolph, Cornelia ^b   Mussolino, Claudio ^a   Joung, J Keith ^d,e   Schambach, Axel ^b   Cathomen, Toni ^a,b  

^a UNIVERSITY OF FREIBURG   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c UNIVERSITY OF FREIBURG   (Germany)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

^f WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; DNA BINDING PROTEIN; NUCLEAR PROTEIN; PRKDC PROTEIN, MOUSE; PROTEIN KINASE; ZINC FINGER PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL MATURATION; CONTROLLED STUDY; FIBROBLAST; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENOME EDITING; IN VITRO STUDY; LYMPHOCYTE DIFFERENTIATION; MALE; MOUSE; NONHUMAN; PLURIPOTENT STEM CELL; RADIOSENSITIVE SEVERE COMBINED IMMUNODEFICIENCY; RADIOSENSITIVITY; SEVERE COMBINED IMMUNODEFICIENCY; SIGNAL TRANSDUCTION; T LYMPHOCYTE; VDJ RECOMBINATION; 3T3 CELL LINE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DEFICIENCY; DISEASE MODEL; GENETICS; GENOME; GENOTYPING TECHNIQUE; HEK293 CELL LINE; HUMAN; INDUCED PLURIPOTENT STEM CELL; METABOLISM; PHENOTYPE;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; DNA-ACTIVATED PROTEIN KINASE; DNA-BINDING PROTEINS; FIBROBLASTS; GENOME; GENOTYPING TECHNIQUES; HEK293 CELLS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MALE; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; PHENOTYPE; PROTEIN KINASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; ZINC FINGERS;

EID: 84930804885     PISSN: 15537390     EISSN: 15537404     Source Type: Journal    
DOI: 10.1371/journal.pgen.1005239     Document Type: Article

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