Genomic editing of the HIV-1 coreceptor CCR5 in adult hematopoietic stem and progenitor cells using zinc finger nucleases

Molecular Therapy

Volumn 21, Issue 6, 2013, Pages 1259-1269

  Li, Lijing ^a   Krymskaya, Ludmila ^a   Wang, Jianbin ^b   Henley, Jill ^c   Rao, Anitha ^a   Cao, Lan Feng ^a   Tran, Chy Anh ^a   Torres Coronado, Monica ^a   Gardner, Agnes ^a   Gonzalez, Nancy ^a   Kim, Kenneth ^b   Liu, Pei Qi ^b   Hofer, Ursula ^c   Lopez, Evan ^c   Gregory, Philip D ^b   Liu, Qing ^a   Holmes, Michael C ^b   Cannon, Paula M ^c   Zaia, John A ^a   Digiusto, David L ^a  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b SANGAMO BIOSCIENCES INC   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CHEMOKINE RECEPTOR CCR5; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN KINASE C; ZINC FINGER NUCLEASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CCR5 GENE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA MODIFICATION; ENZYME ACTIVATION; GENE DISRUPTION; GENE EXPRESSION REGULATION; GENE TARGETING; GENETIC CODE; GENOME EDITING; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PROTEIN EXPRESSION; STEM CELL GENE THERAPY;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 84878528467     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.65     Document Type: Article

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