Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients

Cell Stem Cell

Volumn 13, Issue 6, 2013, Pages 653-658

  Schwank, Gerald ^a,b   Koo, Bon Kyoung ^a,b   Sasselli, Valentina ^a,b   Dekkers, Johanna F ^c   Heo, Inha ^a,b   Demircan, Turan ^a   Sasaki, Nobuo ^a,b   Boymans, Sander ^a   Cuppen, Edwin ^a,b   Van Der Ent, Cornelis K ^c   Nieuwenhuis, Edward E S ^c   Beekman, Jeffrey M ^b,c   Clevers, Hans ^a,b  

^a HUBRECHT INSTITUTE   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTOR RECEPTOR; PROTEIN; UNCLASSIFIED DRUG;

ADULT; ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYSTIC FIBROSIS; GENE LOCUS; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; HUMAN CLONING; INTESTINE CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; STEM CELL; STEM CELL CULTURE; TARGETED GENE REPAIR;

ADULT; ADULT STEM CELLS; ANIMALS; BASE SEQUENCE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; GENETIC THERAPY; HUMANS; INTESTINES; MICE; MOLECULAR SEQUENCE DATA; ORGANOIDS; RNA EDITING; STEM CELLS;

EID: 84890033064     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2013.11.002     Document Type: Article

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